196 patents
Page 6 of 10
Utility
Adiabatic thermal pulse compensating pressure transducer and method
21 Dec 21
Disclosed is a pressure transducer including a body made of a material having a first coefficient of thermal expansion, a fluidic inlet and a fluidic cavity enclosed by the body in fluidic communication with the fluidic inlet.
Gary W. Bertone, Taylor J. Castagna, Robert J. Dumas
Filed: 23 May 19
Utility
Apparatus and method for contactless sampling of solutions and interface to mass spectrometry
21 Dec 21
A method of mass spectrometry is disclosed comprising focusing electromagnetic radiation into a region of a liquid sample 3 below a surface of the liquid sample so as to generate one or more bubbles 4.
Joseph A. Jarrell, LeRoy B. Martin
Filed: 26 Jun 20
Utility
Method of fraction collection for a liquid chromatography system
30 Nov 21
Described are a fraction collector and a method of fraction collection for a liquid chromatography system.
Joshua A. Burnett, James Usowicz, Marc Lemelin, Lucas O. Tiziani, John Lamoureux, Aaron Lebeau
Filed: 26 Feb 15
Utility
Techniques for thermally insulating a chromatographic column
30 Nov 21
Apparatus and methods for performing chromatography may include a chromatography column and a vacuum insulated jacket having an inner wall and an outer wall.
Edouard S. P. Bouvier, Joseph A. Jarrell, Wade P. Leveille, Fabrice Gilles Ernest Gritti, Theodore A. Dourdeville, Michael O. Fogwill
Filed: 14 Apr 17
Utility
Fluid mixer
30 Nov 21
A fluid mixer includes a flow splitter and a mixing chamber.
Peter MacKinnon, Michael R. Jackson
Filed: 24 Aug 18
Utility
Multi-stage displacement pump
23 Nov 21
Described is a multi-stage pump having at least two stages.
Wade P. Leveille, Jacob N. Fairchild, Jeffrey Musacchio, Joseph D. Michienzi
Filed: 18 Jun 19
Utility
Materials and methods for trap-elute mixed mode chromatography
16 Nov 21
In various aspects, the present disclosure pertains to materials (e.g., kits, column assemblies, liquid chromatography systems, etc.) methods for performing liquid chromatography that employ a first column (e.g., a trapping column) and a second column (e.g., an analytical column).
Matthew A. Lauber, Babajide O. Okandeji
Filed: 9 Jul 19
Utility
Methods for preparing liquid mixtures
16 Nov 21
A method of preparing a liquid mixture for use in a liquid chromatography system is provided.
Thomas E. Wheat, Patricia McConville, John R. Lamoureux, Aparna Chavali
Filed: 14 Aug 19
Utility
Mass spectrometer ion source with integrated column
9 Nov 21
Techniques and apparatus for ion source devices with minimized post-column volumes are described.
Michael O. Fogwill, Curt Devlin, Theodore A. Dourdeville, Jacob N. Fairchild, Geoff C. Gerhardt, Wade P. Leveille, Joseph D. Michienzi, Jeffrey Musacchio
Filed: 15 Apr 19
Utility
Device for solid phase extraction and method for use thereof
2 Nov 21
Disclosed is a device for a solid phase extraction comprising two or more of the sorbents to remove phospholipids and salts from a sample, to thereby eliminate matrix effects during mass spectrometry analysis.
Pamela C. Iraneta, Xin Zhang, Frank John Marszalkowski, Jr.
Filed: 16 Dec 15
Utility
Filtration device for chromatographic instruments
2 Nov 21
A liquid chromatography system, includes a fluidic flow path, a chromatography column located in the fluidic flow path, a filtration device located in the fluidic flow path before the chromatography column, the filtration device including a housing having a fluidic inlet, a fluidic outlet, wherein at least a portion of the fluidic flow path is located between the fluidic inlet and the fluidic outlet and at least one filter disposed in the portion of the fluidic flow path, wherein the at least one filter is made of a micromachined material.
Kevin D. Wyndham, Moon Chul Jung, Abhijit Tarafder, Wade P. Leveille, Sr.
Filed: 5 Apr 19
Utility
Variable output liquid chromatography pump drive
2 Nov 21
Disclosed is a liquid chromatography solvent pump including a motor, a first piston, a second piston, and a variable output drive system coupling the motor to at least one of the first piston and the second piston.
Jeffrey Musacchio, Joseph Michienzi
Filed: 17 Sep 19
Utility
Twist lock compliant needle for detection of contact
2 Nov 21
A twist-lock compliant needle including a housing component surrounding a needle holder holding a rigidly mounted needle, the housing component including a biasing element disposed therein, wherein the biasing element compresses as a needle tip of the needle contacts a surface is provided.
David A. Simpson, Joshua A. Burnett, John M. Auclair
Filed: 16 Jul 19
Utility
Non-antibody high-affinity-based sample preparation, sorbent, devices and methods
26 Oct 21
In various aspects, the present disclosure pertains to sorbents for isolating at least one target protein from a liquid sample, the sorbents comprising a solid support comprising attached at least one attached high affinity reagent with an affinity for the at least one target protein.
Laks Iyer, Beatrice W. Muriithi
Filed: 21 Mar 19
Utility
Multidimensional chromatography method for analysis of antibody-drug conjugates
19 Oct 21
The present disclosure relates to a sensitive, multidimensional chromatography method for extraction, detection, and quantification of non-conjugated cytotoxic agents and associated linker molecules used in cysteine based antibody-drug-conjugate production.
Robert Birdsall
Filed: 8 Sep 16
Utility
System and method for sample introduction within a chromatography system
19 Oct 21
The present disclosure relates to methodologies, systems, apparatus, and kits for introducing a sample within a chromatography system.
Michael O. Fogwill, Joseph D. Michienzi
Filed: 29 May 19
Utility
Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation
19 Oct 21
Methods for preparing labeled glycosylamines from a complex matrix are provided.
Matthew A. Lauber
Filed: 19 Jun 17
Utility
Systems, methods and devices for decreasing solubility problems in chromatography
12 Oct 21
A significant reduction in extra-column band broadening can be achieved by decoupling the injection system from the main solvent flow line.
Abhijit Tarafder
Filed: 19 Oct 16
Utility
Systems, devices, and methods for controlling the temperature of a CO2 pump
12 Oct 21
Methodologies, systems, and computer-readable media are provided for controlling the mass flow rate within a CO2 based chromatography system.
Abhijit Tarafder, Jason Hill, Joshua Shreve
Filed: 26 Oct 18
Utility
Method and an apparatus for analyzing a complex sample
5 Oct 21
A method of analyzing a complex sample includes performing a sequential chromatographic-IMS-MS analysis of a sample to obtain a plurality of experimental mass spectra having isotopic clusters, wherein each spectrum of the plurality of spectra is associated with a chromatographic retention time and an ion-mobility drift time.
Scott J. Geromanos, Marc V. Gorenstein, Daniel Golick, Steven J. Ciavarini
Filed: 19 May 20