9 patents
Utility
Method and apparatus for use in temperature controlled processing of microfluidic samples
1 Feb 22
Embodiments of the invention comprise microfluidic devices, instrumentation interfacing with those devices, processes for fabricating that device, and methods of employing that device to perform PCR amplification.
Morten J. Jensen, Andrea W. Chow, Colin B. Kennedy, Stephane Mouradian
Filed: 25 May 18
Utility
Method and apparatus for generating thermal melting curves in a microfluidic device
2 Nov 21
The present invention provides novel methods and devices that employ microfluidic technology to generate molecular melt curves.
Steven A. Sundberg, Michael R. Knapp, Ivor T. Knight, Deborah J. Boles, Aaron Rulison, Wesley B. Dong, Andrew Fabans, Edward Donlon, Robert Moti, Michael Slater
Filed: 27 Jun 16
Utility
In-vivo reactive species imaging
22 Jun 21
The disclosure features methods that include: administering to a subject a composition that includes particles, where each one of the particles features at least one targeting group that binds to a structural entity in the subject and at least one reacting group that reacts chemically with a reactive oxygen species in the subject, and where the particle emits luminescence when the reaction occurs; detecting the luminescence emission from the particles; and displaying an image of the subject showing locations of at least some reactive oxygen species in the subject based on the detected luminescence.
Sunetra Ray, Daniel Ansaldi, Rajendra Singh
Filed: 7 Nov 18
Utility
Method and System of Microfluidic Immunoassay Using Magnetic Beads
18 Mar 21
A microfluidic Western blot method and system including a microfluidic western blot method for immunoassay of proteins, the method including introducing a sample including the proteins onto a chip; electrophoretically separating the proteins; binding the separated proteins to beads to form protein-attached beads, the beads being magnetic; flowing the protein-attached beads into a magnetic holding region; applying a magnetic field to the magnetic holding region to fix the protein-attached beads in place within the magnetic holding region; binding primary antibodies to target proteins on the protein-attached beads; binding secondary antibodies to the bound primary antibodies; and detecting the bound secondary antibodies.
Andrew Barry, Laurel Provencher, Seth Cohen, I-JANE CHEN, Jun Yan, Jingjing Wang
Filed: 25 Nov 20
Utility
Method and system of microfluidic immunoassay using magnetic beads
28 Dec 20
A microfluidic Western blot method and system including a microfluidic western blot method for immunoassay of proteins, the method including introducing a sample including the proteins onto a chip; electrophoretically separating the proteins; binding the separated proteins to beads to form protein-attached beads, the beads being magnetic; flowing the protein-attached beads into a magnetic holding region; applying a magnetic field to the magnetic holding region to fix the protein-attached beads in place within the magnetic holding region; binding primary antibodies to target proteins on the protein-attached beads; binding secondary antibodies to the bound primary antibodies; and detecting the bound secondary antibodies.
Andrew Barry, Laurel Provencher, Seth Cohen, I-Jane Chen, Jun Yan, Jingjing Wang
Filed: 3 Dec 17
Utility
Lane-level vehicle navigation for vehicle routing and traffic management
5 Oct 20
Lane-level vehicle routing and navigation apparatus includes a simulation module that performs microsimulation of individual vehicles in a traffic stream, and a lane-level optimizer that evaluates conditions along candidate paths from an origin to a destination as determined by the simulation module, and determines recommended lane-level maneuvers along the candidate paths.
Howard Slavin, Qi Yang, Daniel Morgan, Andres Rabinowicz, Jonathan Brandon, Ramachandran Balakrishna
Filed: 3 May 18
Utility
Manipulation of objects in microfluidic devices using external electrodes
20 Jul 20
The invention provides microfluidic devices, systems, and methods for manipulating an object within a channel of a microfluidic device using an external electrode.
Joshua I. Molho, Daniel G. Stearns, I-Jane Chen, Danh Tran, Bradley W. Rice, Tobias Daniel Wheeler
Filed: 15 Nov 15
Utility
Systems and methods for sampling of amplification products
11 May 20
The invention provides systems and methods for processing samples.
Edward H. Thorne, IV, Abbie L. Esterman
Filed: 26 Jun 17
Utility
Methods of detecting low copy nucleic acids
30 Sep 19
Methods are provided for detecting low copy nucleic acids of interest in a sample.
Michael R. Knapp, Jill M. Baker, Andrea W. Chow, Anne R. Kopf-Sill, Michael Spaid
Filed: 13 Apr 14
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