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Inhibitor Therapeutics (INTI)

Utility
Treatment and Prognostic Monitoring of Proliferation Disorders Using Hedgehog Pathway Inhibitors
2 Dec 20
The present invention concerns methods for treating a proliferation disorder, such as prostate cancer, basal cell carcinoma, lung cancer, and other cancers, using an inhibitor of the Hedgehog pathway (HhP); and methods for monitoring subjects undergoing such treatments based on biomarkers and other criteria predictive of efficacy.
NICHOLAS J. VIRCA, FRANCIS E. O'DONNELL, JR.
Filed: 11 May 20
Utility
Azole Treatment Regimen with Reduced Hepatotoxicity
4 Dec 19
The present invention concerns methods for managing hepatotoxicity in a subject undergoing treatment with a composition comprising an azole inhibitor of the Hedgehog signaling pathway (azole inhibitor), such as itraconazole or an analogue thereof, comprising suspending, for a period of time, the administration of the composition to the subject exhibiting hepatotoxicity, and re-administering the composition to the subject with a reduced dosage of the azole inhibitor.
NICHOLAS J. VIRCA
Filed: 29 May 19
Utility
Hedgehog Pathway Inhibition for Treatment of High-risk Basal Cell Carcinoma or High-risk Basal Cell Carcinoma Nevus Syndrome
4 Dec 19
The present invention concerns methods for treating high-risk basal cell carcinoma (BCC) or high-risk basal cell carcinoma nevus syndrome (BCCNS) in a subject, comprising administering a composition comprising an azole inhibitor of the Hedgehog signaling pathway (azole inhibitor) to the subject.
NICHOLAS J. VIRCA
Filed: 29 May 19
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