107 patents
Utility
Handheld Electroporation Devices, And Related Systems And Methods
18 Jan 24
A method for preparing an electroporation device to deliver an electroporation treatment includes steps of delivering a charge current from at least one battery through a charge circuit to a supercapacitor unit and charging the supercapacitor unit with the charge current.
Beat Stadelmann, Andrew Booth, Jay McCoy, Charu Mather
Filed: 24 Feb 23
Utility
Nucleic acid encoding optimized immunogenic peptide that targets follicle stimulating hormone receptor
9 Jan 24
Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types.
David Weiner, Alfredo Perales Puchalt, Jian Yan, Anna Maria Slager
Filed: 29 Aug 17
Utility
Vaccines For Recurrent Respiratory Papillomatosis And Methods Of Using The Same
28 Dec 23
Provided herein are nucleic acid molecules encoding an HPV antigen.
Stephanie Ramos, Jewell Walters, Jian Yan, Anna Slager, Charles Reed, Kate Broderick
Filed: 17 Jul 23
Utility
Vaccines for human papilloma virus and methods for using the same
19 Dec 23
Improved anti-HPV immunogens and nucleic acid molecules that encode them are disclosed.
David Weiner, Jian Yan
Filed: 5 Jan 21
Utility
DNA antibody constructs for use against HIV
19 Dec 23
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an HIV antigen.
David Weiner, Megan Wise
Filed: 27 Mar 18
Utility
Electroporation Device with Detachable Needle Array with Lock-out System
14 Dec 23
An electroporation device with a needle array removably attached thereto, the needle array having a body, a shroud movable with respect to the body between a rest position and one or more actuated positions, and an auto-lock assembly.
Beat Stadelman, Stephen Kemmerrer, Alejandro Campillo-Agusti, Eduardo Ho, Nathan Lovell, Steven Masterson
Filed: 25 Aug 23
Utility
Cancer vaccines and methods of treatment using the same
31 Oct 23
The invention provides a vaccine comprising a nucleic acid molecule that encodes a dog telomerase reverse transcriptase (dTERT) antigen, as well as methods of using the vaccine to induce an immune response against a TERT and to treat cancer in a mammal.
Jian Yan
Filed: 9 Apr 21
Utility
MERS-CoV vaccine
31 Oct 23
Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen.
David Weiner, Karuppiah Muthumani, Niranjan Y. Sardesai
Filed: 10 Sep 21
Utility
Methods Of Treatment Of High Grade Squamous Intraepithelial Lesion (HSIL)
26 Oct 23
Described are methods of treating human papillomavirus (HPV) type 16- or HPV type 18-related High-grade Squamous Intraepithelial Lesion (HSIL) of the cervix.
Matthew P. Morrow, Kimberly A. Kraynyak, Albert J. Sylvester, Naseem Prostak, Laurent M. Humeau
Filed: 14 Apr 23
Utility
Vaccines Against Coronavirus and Methods of Use
26 Oct 23
Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
Jian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
Filed: 2 May 23
Utility
Immunogenic Compositions Against SARS-COV-2 Variants And Their Methods Of Use
26 Oct 23
Disclosed herein are nucleic acid molecules encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a SARS-CoV-2 infection in a subject.
Kate Broderick, Trevor Smith, Richa Kalia, Viviane Machado de Mello Andrade
Filed: 14 Apr 23
Utility
Intradermal Injection Device
19 Oct 23
Embodiments herein relate to the field of injections, for instance needle-free injections, and more specifically, to methods and apparatus for spring-driven intramuscular and intradermal injections.
Daniel E. Williamson, John R. Marshall
Filed: 22 Jun 23
Utility
WT1 Vaccine
21 Sep 23
Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen.
David B. Weiner, Jian Yan, Jewell Walters
Filed: 31 Jan 23
Utility
Compositions and Methods for Treating Vulvar Dysplasia
7 Sep 23
The use of anti-HPV immunogens and nucleic acid molecules that encode them for the treatment and prevention of vulvar dysplasia are disclosed.
Jian Yan
Filed: 2 Apr 21
Utility
Vaccines for recurrent respiratory papillomatosis and methods of using the same
5 Sep 23
Provided herein are nucleic acid molecules encoding an HPV antigen.
Stephanie Ramos, Jewell Walters, Jian Yan, Anna Slager, Charles Reed, Kate Broderick
Filed: 14 May 21
Utility
Intradermal injection device
15 Aug 23
Embodiments herein relate to the field of injections, for instance needle-free injections, and more specifically, to methods and apparatus for spring-driven intramuscular and intradermal injections.
Daniel E. Williamson, John R. Marshall
Filed: 25 Oct 19
Utility
Method and Device for Minimally Invasive In Vivo Transfection of Adipose Tissue Using Electroporation
10 Aug 23
A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surface and the second contact surface define a treatment zone therebetween.
Paul FISHER, Kate Broderick, Jay McCoy
Filed: 18 Apr 23
Utility
Compositions and Methods for Treating Anal High-grade Squamous Intraepithelial Lesion (Hsil)
27 Jul 23
The use of anti-HPV immunogens and nucleic acid molecules that encode them for the treatment and prevention of anal high-grade squamous intraepithelial lesion are disclosed.
Jian Yan, Jong Joseph Kim, Prakash Bhuyan, Jeffrey Skolnik
Filed: 21 Oct 22
Utility
Method and device for minimally invasive in vivo transfection of adipose tissue using electroporation
27 Jun 23
A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surf ace and the second contact surface define a treatment zone therebetween.
Paul Fisher, Kate Broderick, Jay McCoy
Filed: 22 Sep 17
Utility
Vaccines against coronavirus and methods of use
30 May 23
Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
Jian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
Filed: 25 Feb 21