64 patents
Utility
Handheld Electroporation Devices, And Related Systems And Methods
18 Jan 24
A method for preparing an electroporation device to deliver an electroporation treatment includes steps of delivering a charge current from at least one battery through a charge circuit to a supercapacitor unit and charging the supercapacitor unit with the charge current.
Beat Stadelmann, Andrew Booth, Jay McCoy, Charu Mather
Filed: 24 Feb 23
Utility
Vaccines For Recurrent Respiratory Papillomatosis And Methods Of Using The Same
28 Dec 23
Provided herein are nucleic acid molecules encoding an HPV antigen.
Stephanie Ramos, Jewell Walters, Jian Yan, Anna Slager, Charles Reed, Kate Broderick
Filed: 17 Jul 23
Utility
Electroporation Device with Detachable Needle Array with Lock-out System
14 Dec 23
An electroporation device with a needle array removably attached thereto, the needle array having a body, a shroud movable with respect to the body between a rest position and one or more actuated positions, and an auto-lock assembly.
Beat Stadelman, Stephen Kemmerrer, Alejandro Campillo-Agusti, Eduardo Ho, Nathan Lovell, Steven Masterson
Filed: 25 Aug 23
Utility
Methods Of Treatment Of High Grade Squamous Intraepithelial Lesion (HSIL)
26 Oct 23
Described are methods of treating human papillomavirus (HPV) type 16- or HPV type 18-related High-grade Squamous Intraepithelial Lesion (HSIL) of the cervix.
Matthew P. Morrow, Kimberly A. Kraynyak, Albert J. Sylvester, Naseem Prostak, Laurent M. Humeau
Filed: 14 Apr 23
Utility
Vaccines Against Coronavirus and Methods of Use
26 Oct 23
Disclosed herein are nucleic acid molecules encoding a SARS-CoV-2 spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection in a subject.
Jian Yan, Kate Broderick, David Weiner, Kar Muthumani, Ami Patel
Filed: 2 May 23
Utility
Immunogenic Compositions Against SARS-COV-2 Variants And Their Methods Of Use
26 Oct 23
Disclosed herein are nucleic acid molecules encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a SARS-CoV-2 infection in a subject.
Kate Broderick, Trevor Smith, Richa Kalia, Viviane Machado de Mello Andrade
Filed: 14 Apr 23
Utility
Intradermal Injection Device
19 Oct 23
Embodiments herein relate to the field of injections, for instance needle-free injections, and more specifically, to methods and apparatus for spring-driven intramuscular and intradermal injections.
Daniel E. Williamson, John R. Marshall
Filed: 22 Jun 23
Utility
WT1 Vaccine
21 Sep 23
Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen.
David B. Weiner, Jian Yan, Jewell Walters
Filed: 31 Jan 23
Utility
Compositions and Methods for Treating Vulvar Dysplasia
7 Sep 23
The use of anti-HPV immunogens and nucleic acid molecules that encode them for the treatment and prevention of vulvar dysplasia are disclosed.
Jian Yan
Filed: 2 Apr 21
Utility
Method and Device for Minimally Invasive In Vivo Transfection of Adipose Tissue Using Electroporation
10 Aug 23
A method and device for electroporating adipocytes in the adipose layer of tissue, where the device includes a frame, a first electrode coupled to the frame having a first contact surface, a second electrode coupled to the frame having a second contact surface, and where the first contact surface and the second contact surface define a treatment zone therebetween.
Paul FISHER, Kate Broderick, Jay McCoy
Filed: 18 Apr 23
Utility
Compositions and Methods for Treating Anal High-grade Squamous Intraepithelial Lesion (Hsil)
27 Jul 23
The use of anti-HPV immunogens and nucleic acid molecules that encode them for the treatment and prevention of anal high-grade squamous intraepithelial lesion are disclosed.
Jian Yan, Jong Joseph Kim, Prakash Bhuyan, Jeffrey Skolnik
Filed: 21 Oct 22
Utility
a Tolerable and Minimally Invasive Skin Electroporation Device
11 May 23
A novel electroporation device for the delivery of vaccines that is both effective in generating a protective immune response and tolerable delivery to a subject (or near painless); and also methods of using same device to vaccinate a subject against a variety of infectious diseases and types of cancer in a near painless.
Kate Broderick, Jay McCoy, Stephen V. Kemmerrer, Feng Lin, Rune Kjeken
Filed: 25 Jul 22
Utility
Tert Immunogenic Compositions and Methods of Treatment Using the Same
13 Apr 23
Disclosed herein are compositions comprising optimized consensus TERT antigens and methods for treating cancer and in particular immunogenic compositions that treat and provide protection against tumor.
David Weiner, Jian Yan
Filed: 11 Oct 22
Utility
In Vivo Use of Chondroitinase And/or Hyaluronidase to Enhance Delivery of an Agent
23 Mar 23
Disclosed herein are methods of delivering an agent to a subject.
Trevor Smith, Nina Schommer, Kate Broderick, Bryan Yung, Katherine Schultheis
Filed: 30 Nov 22
Utility
Combination Therapy to Treat Brain Cancer
9 Mar 23
Provided herein are methods of treating brain cancer in a subject, comprising evaluating one or more biological samples from a subject who has brain cancer for the presence of a miRNAs and administering interleukin-12 (IL-12); an immunogenic composition of human telomerase reverse transcriptase (hTERT), Wilms Tumor-1 (WT-1), and prostate specific membrane antigen (PSMA); and an anti-programmed cell death receptor 1 (PD-1) antibody to said subject if the subject has an increased expression level of the mIR-331-3p miRNA or isomiRs thereof and the miR-1537-3p miRNA or isomiRs thereof relative to a control population of subjects.
Amy-Lee Bredlau, Israel Lowy, Jeffrey Skolnik, Jian Yan, Bernadette Ferraro, Jewell Walters, Albert J. Sylvester, III, Kimberly A. Kraynyak, Matthew P. Morrow, Elisabeth Gillespie
Filed: 12 Aug 22
Utility
Dna Antibody Constructs and Method of Using Same
26 Jan 23
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody.
David B. Weiner, Karuppiah Muthumani, Seleeke Flingai, Niranjan Sardesai
Filed: 3 Mar 22
Utility
Side-Port Injection Devices For Use With Electroporation, and Related Systems and Methods
19 Jan 23
An injection device for in vivo delivery of an agent includes a tubular body defining a lumen that extends along a central axis that is oriented along a longitudinal direction.
Paul Fisher, Jay McCoy, Alison A. Generotti, Brenden Ulysses Zounes, Ryne Lucas Contreras
Filed: 30 Jun 22
Utility
Electroporation Device and Injection Apparatus
12 Jan 23
An apparatus is provided for injecting a fluid into body tissue, the apparatus comprising: a hollow needle; and fluid delivery means, wherein the apparatus is adapted to actuate the fluid delivery means in use so as to automatically inject fluid into body tissue during insertion of the needle into the said body tissue.
Iacob Mathiesen, Torunn E. Tjelle, Knut Arvid Sorensen Rekdahl, Bjorn David-Andersen
Filed: 19 Sep 22
Utility
Cancer Vaccines and Methods of Treatment Using the Same
12 Jan 23
Disclosed herein are compositions and methods for treating cancer and in particular vaccines that treat and provide protection against tumor growth.
David B. Weiner, Jian Yan, Karuppiah Muthumani, Jewell Walters
Filed: 20 Jul 22
Utility
Improved Vaccines for Recurrent Respiratory Papillomatosis and Methods for Using the Same
5 Jan 23
The use of anti-HPV immunogens and nucleic acid molecules that encode them for the treatment and prevention of RRP are disclosed.
David B. Weiner, Jian Yan
Filed: 26 Oct 20