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CYTK Cytokinetics

GRANT
Utility
Process for the preparation of an amino-pyrimidine and intermediates thereof
12 Oct 21
Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof.
Matthew Peterson, Kevin Lu, Bradley Morgan, David Morgans, Tohru Fukuyama
Filed: 26 Dec 18
APP
Utility
Cardiac Sarcomere Inhibitors
9 Sep 21
Bradley P. MORGAN, Mark VANDERWAL, Chihyuan CHUANG
Filed: 25 Jun 19
APP
Utility
Cardiac Sarcomere Inhibitors
19 Aug 21
Bradley P. MORGAN, Chihyuan CHUANG
Filed: 25 Jun 19
APP
Utility
Salts and Crystal Forms of Omecamtiv Mecarbil
22 Jul 21
Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
Henry Morrison, Sheng Cui, Kyle Quasdorf, Evelyn Yanez, Bin Peter Quan, Ron C. Kelly, Sebastien Caille, Lingyun Xiao, David Pearson, Jaclyn Raeburn, Ailsa Golightly, Bradley Morgan, Matthew Peterson, Alex Eberlin, Alexander Oblezov
Filed: 16 Aug 19
APP
Utility
Compounds, Compositions and Methods
1 Jul 21
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, JR.
Filed: 12 Mar 21
APP
Utility
Cardiac Sarcomere Inhibitors
20 May 21
Chihyuan CHUANG, Bradley P. MORGAN, Mark VANDERWAL, Wenyue WANG, Luke W. ASHCRAFT
Filed: 4 Sep 20
GRANT
Utility
Compounds, compositions and methods
13 Apr 21
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, Jr.
Filed: 2 Jul 19
APP
Utility
Process for the Preparation of an Amino-pyrimidine and Intermediates Thereof
4 Mar 21
Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof.
Matthew PETERSON, Kevin LU, Bradley MORGAN, David MORGANS, Tohru FUKUYAMA
Filed: 26 Dec 18
APP
Utility
Amino-pyrimidine Skeletal Muscle Modulators
18 Feb 21
Zhe YANG, Alex R. MUCI, Jeffrey WARRINGTON, Gustave BERGNES, Bradley P. MORGAN, Chihyuan CHUANG, Antonio ROMERO, Scott COLLIBEE, Xiangping QIAN, Pu-Ping LU
Filed: 28 Jul 20
GRANT
Utility
Bisamide sarcomere activating compounds and uses thereof
26 Jan 21
Luke Ashcraft, Alessandro Boezio, John Butler, Aroop Chandra, Chihyuan Chuang, Scott E. Collibee, Mikkel V. Debenedetto, Vincent DiMassa, Russell Graceffa, Justin Malinowski, David Moebius, Bradley Paul Morgan, Joshua Payette, Antonio Romero, David St. Jean, Jr., Richard Vargas, John Yeoman, Hanmo Zhang, Alan Cheng, Felix Gonzalez Lopez De Turiso, Michael Garrett Johnson
Filed: 27 Mar 20
GRANT
Utility
Cardiac sarcomere inhibitors
16 Nov 20
Chihyuan Chuang, Bradley P. Morgan, Mark Vanderwal, Wenyue Wang, Luke W. Ashcraft
Filed: 17 Jan 19
APP
Utility
Salt of Omecamtiv Mecarbil and Process for Preparing Salt
21 Oct 20
Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
Sheng Cui, Henry Morrison, Karthik Nagapudi, Shawn Walker, Charles Bernard, Karl Bennett Hansen, Neil Fred Langille, Alan Martin Allgeier, Steven Mennen, Jacqueline C.S. Woo, Bradley Paul Morgan, Alex Muci
Filed: 1 Jul 20
GRANT
Utility
Amino-pyrimidine skeletal muscle modulators
7 Sep 20
Zhe Yang, Alex R. Muci, Jeffrey Warrington, Gustave Bergnes, Bradley P. Morgan, Chihyuan Chuang, Antonio Romero, Scott Collibee, Xiangping Qian, Pu-Ping Lu
Filed: 12 Mar 19
GRANT
Utility
Methods for preparing substituted imidazo[4,5-b]pyrazines
7 Sep 20
Bradley P. Morgan, David J. Morgans, Jr., Alex Muci
Filed: 6 Apr 14
APP
Utility
Heterocyclic Compounds and Their Uses
2 Sep 20
Provided are certain pharmaceutical formulations of omecamtiv mecarbil and methods for their preparation and use.
Mingda Bi, Robert Kuehl
Filed: 22 Sep 19
APP
Utility
Tetrahydroisoquinoline Derivatives
26 Aug 20
Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere.
Ippei SATO, Takashi KAMIKUBO, Masanori MIURA, Yuji MATSUSHIMA, Hiroaki TANAKA, Yasuhiro SHIINA, Susumu YAMAKI, Tomoyuki SAITO, Hiroshi KIYOHARA, Munemichi OHE, Kayoko MIHARA, Bradley Paul MORGAN, Fady MALIK, Scott Emile COLLIBEE, Luke ASHCRAFT, Pu-Ping LU, Jeffrey Michael WARRINGTON, Marc GARARD
Filed: 10 May 20
GRANT
Utility
Bisamide sarcomere activating compounds and uses therof
27 Jul 20
Luke Ashcraft, Alessandro Boezio, John Butler, Aroop Chandra, Chihyuan Chuang, Scott E. Collibee, Mikkel Debenedetto, Vincent DiMassa, Russell Graceffa, Justin Malinowski, David Moebius, Bradley P. Morgan, Joshua Payette, Antonio Romero, David St. Jean, Jr., Richard Vargas, John Yeoman, Hanmo Zhang, Alan Cheng, Felix Gonzalez Lopez De Turiso, Michael Garrett Johnson
Filed: 12 Sep 18
APP
Utility
Bisamide Sarcomere Activating Compounds and Uses Thereof
15 Jul 20
Luke Ashcraft, Alessandro Boezio, John Butler, Aroop Chandra, Chihyuan Chuang, Scott E. Collibee, Mikkel V. Debenedetto, Vincent DiMassa, Russell Graceffa, Justin Malinowski, David Moebius, Bradley Paul Morgan, Joshua Payette, Antonio Romero, David St. Jean, JR., Richard Vargas, John Yeoman, Hanmo Zhang, Alan Cheng, Felix Gonzalez Lopez De Turiso, Michael Garrett Johnson
Filed: 26 Mar 20
APP
Utility
Bisamide Sarcomere Activating Compounds and Uses Thereof
15 Jul 20
Luke Ashcraft, Alessandro Boezio, John Butler, Aroop Chandra, Chihyuan Chuang, Scott E. Collibee, Mikkel V. Debenedetto, Vincent DiMassa, Russell Graceffa, Justin Malinowski, David Moebius, Bradley Paul Morgan, Joshua Payette, Antonio Romero, David St. Jean, JR., Richard Vargas, John Yeoman, Hanmo Zhang, Alan Cheng, Felix Gonzalez Lopez De Turiso, Michael Garrett Johnson
Filed: 26 Mar 20
GRANT
Utility
Tetrahydroisoquinoline derivatives
22 Jun 20
Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere.
Ippei Sato, Takashi Kamikubo, Masanori Miura, Yuji Matsushima, Hiroaki Tanaka, Yasuhiro Shiina, Susumu Yamaki, Tomoyuki Saito, Hiroshi Kiyohara, Munemichi Ohe, Kayoko Mihara, Bradley Paul Morgan, Fady Malik, Scott Emile Collibee, Luke Ashcraft, Pu-Ping Lu, Jeffrey Michael Warrington, Marc Garard
Filed: 3 Mar 19
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