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LXRX Lexicon Pharmaceuticals

GRANT
Utility
Antibodies that bind Notum Pectinacetylesterase
13 Jul 21
Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.
Robert Joseph Brommage, Jr., Xiao Feng, Seokjoo Hong, Gregory Landes, Jeff Liu, David George Potter, David Reed Powell
Filed: 15 Feb 19
GRANT
Utility
Crystalline solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide and methods of their synthesis
6 Apr 21
Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide, and salts, solvates and cocrystals thereof, are disclosed.
Mark Stephen Bednarz, Kuangchu Dai, Jeffrey Manning Eckert, Ngiap-Kie Lim, Lauren Sirois, Wenxue Wu, Matthew Mangzhu Zhao
Filed: 23 Sep 19
APP
Utility
Compositions Comprising and Methods of Using Inhibitors of Sodium-glucose Cotransporters 1 and 2
11 Feb 21
Pharmaceutical dosage forms useful for improving the cardiovascular and/or metabolic health of patients, particularly those suffering from type 2 diabetes, are disclosed, as well as methods of their manufacture.
Jinling CHEN, Nasser N NYAMWEYA, Kenneth K. H. ONG
Filed: 17 Feb 20
APP
Utility
Use of Sotagliflozin for the Treatment of Patients with Type 1 Diabetes Mellitus
11 Feb 21
The invention relates to the use of sotagliflozin to improve glycemic control in adults with type 1 diabetes mellitus with a Body Mass Index (BMI)≥27 kg/m2.
Phillip BANKS, Sangeeta SAWHNEY
Filed: 28 Feb 20
APP
Utility
Solid Dosage Forms of (S)-ethyl 2-AMINO-3-(4-(2-AMINO-6-((R)-1-(4-CHLORO-2-(3-METHYL-1H-PYRAZOL-1-YL)PHENYL)-2,2,2-TRIFLUOROETHOXY)PYRIMIDIN-4-YL)PHENYL)PROPANOATE
14 Jan 21
Solid pharmaceutical dosage forms comprising (S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate (telotristat) are disclosed, as well as methods of making them and compositions useful in their manufacture.
Jinling CHEN, Matthew S. DEAVER, Richard J. HOLL, Kalyan NUGURU
Filed: 19 Nov 19
APP
Utility
Crystalline Solid Forms of N-(1-((2-(DIMETHYLAMINO)ETHYL)AMINO)-2-METHYL-1-OXOPROPAN-2-YL)-4-(4-(2-METHYL-5-((2S,3R,4R,5S,6R)-3,4,5-TRIHYDROXY-6-(METHYLTHIO)TETRAHYDRO-2H-PYRAN-2-YL)BENZYL)PHENYL)BUTANAMIDE and Methods of Their Synthesis
12 Aug 20
Methods of preparing, and solid forms of N-(1-((2-(dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)butanamide, and salts, solvates and cocrystals thereof, are disclosed.
Mark Stephen BEDNARZ, Kuangchu DAI, Jeffrey Manning ECKERT, Ngiap-Kie LIM, Lauren SIROIS, Wenxue WU, Matthew Mangzhu ZHAO
Filed: 22 Sep 19
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