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UTHR United Therapeutics

APP
Utility
Controlled Release Pharmaceutical Formulations
14 Oct 21
Peter LAING
Filed: 10 May 21
GRANT
Utility
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
12 Oct 21
Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin.
Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
Filed: 21 Sep 18
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Ungulates with genetically modified immune systems
10 Aug 21
The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci.
Kevin Wells, David Ayares
Filed: 4 Mar 19
APP
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Inhalation Formulations of Treprostinil
17 Jun 21
The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions.
Michael WADE
Filed: 25 Feb 21
APP
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Salts of Treprostinil
17 Jun 21
Provided are novel treprostinil salts as well as methods for making treprostinil salts.
Hitesh BATRA, Vijay SHARMA, Sanmin YANG, Yi ZHANG
Filed: 30 Nov 20
APP
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Extracellular Vesicles and Their Uses
10 Jun 21
Provided are methods for isolating potent extracellular vesicle populations from mesenchymal stem cells.
Roger Ilagan, Sarah Hogan, John Cheadle, Carolina Papu
Filed: 2 Dec 20
APP
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Extracellular Vesicles with Enhanced Potency
27 May 21
Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.
Sarah HOGAN, Roger Marquez ILAGAN, Maria Pia RODRIGUEZ, Carolina MEDRANO, John CHEADLE
Filed: 1 Feb 21
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Method for Purifying Antibodies
13 May 21
Disclosed here includes a method for purifying a biologic composition, comprising diafiltering the biologic composition into a composition comprising phosphate buffered saline (PBS) to obtain a purified composition.
David Meh, Timothy Atolagbe, G. Mark Farquharson, Samir Shaban, Mary Koleck, George Mitra
Filed: 21 Jan 21
GRANT
Utility
Controlled release pharmaceutical formulations
11 May 21
Peter Laing
Filed: 29 Oct 19
APP
Utility
Treprostinil Prodrugs
29 Apr 21
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Ken PHARES, Hitesh BATRA, Liang GUO, Adam Marc SILVERSTEIN
Filed: 4 Jan 21
GRANT
Utility
Extracellular vesicles with enhanced potency
16 Mar 21
Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.
Sarah Hogan, Roger Marquez Ilagan, Maria Pia Rodriguez, Carolina Medrano, John Cheadle
Filed: 1 May 18
GRANT
Utility
Compounds and methods for delivery of prostacyclin analogs
16 Mar 21
This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
Ken Phares
Filed: 23 Jul 19
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Methods and Compositions for Culturing Alveolar Cells
4 Mar 21
Described herein are methods and compositions for use in expanding alveolar epithelial cells.
Laila Roudsari, Daren Robinson, Benjamin Rusche, Sajini Nair, Ashley R. Dockham
Filed: 26 Aug 20
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Pre-conditioned Extracellular Vesicles and Methods of Production
25 Feb 21
A method for treating inflammatory diseases is provided.
Pamela Tiet, Roger Ilagan
Filed: 21 Aug 20
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Treprostinil Prodrugs
25 Feb 21
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Kenneth Robert Phares, Hitesh Batra, Liang Guo
Filed: 24 Aug 20
GRANT
Utility
Tissue products derived from animals lacking any expression of functional alpha 1, 3 galactosyltransferase
9 Feb 21
The present invention provides tissues derived from animals, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha-1,3-GT).
David Ayares, Paul Rohricht
Filed: 24 Oct 18
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Treatment of Pulmonary Arterial Hypertension with Prostacyclin-treated Endothelial Progenitor Cells
4 Feb 21
The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.
Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
Filed: 16 Oct 20
GRANT
Utility
Method for purifying antibodies
2 Feb 21
Disclosed here includes a method for purifying a biologic composition, comprising diafiltering the biologic composition into a composition comprising phosphate buffered saline (PBS) to obtain a purified composition.
David Meh, Timothy Atolagbe, G. Mark Farquharson, Samir Shaban, Mary Koleck, George Mitra
Filed: 14 Jan 16
APP
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Mitochondrial Treatment of Organs for Transplantation
14 Jan 21
Methods and compositions relating to isolated mitochondria are disclosed.
Thomas Petersen, Sarah Hogan, Roger Ilagan, Caryn Cloer
Filed: 17 Jun 20
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Systems and Methods for Exchanging Small Molecules with Fluid
25 Nov 20
An apparatus for exchanging small molecules with a fluid includes a small-molecule conduit for providing a first fluid having a first type of small molecule, a target fluid conduit for providing a target fluid having a second type of small molecule therein, and a carrier fluid conduit for providing a carrier fluid that is configured (i) to receive at least some of the first type of small molecule from the first fluid and transfer at least some of the first type of small molecule to the target fluid and (ii) to receive at least some of the second type of small molecule from the target fluid and transfer at least some of the second type of small molecule to the first fluid.
Anna M. Galea
Filed: 21 May 20
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