93 patents
Utility
Ralinepag Prodrugs and Uses Thereof
4 Jan 24
Described herein are ralinepag prodrugs, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatment with a prostacyclin (IP) receptor agonist compound, such as but not limited to pulmonary hypertension (PH) diseases.
Hitesh BATRA, Patrick POISSON, Liang GUO, Susovan JANA, Sri Harsha TUMMALA
Filed: 17 Mar 23
Utility
Crystalline Prostacyclin (Ip) Receptor Agonist and Uses Thereof
21 Dec 23
Described herein are crystalline forms of a prostacyclin (IP) receptor agonist compound, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatment with a prostacyclin (IP) receptor agonist compound.
Kenneth PHARES
Filed: 14 Feb 23
Utility
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
12 Dec 23
Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin.
Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
Filed: 8 Sep 21
Utility
Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells
12 Dec 23
The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.
Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
Filed: 16 Oct 20
Utility
Treatment for interstitial lung disease
28 Nov 23
Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.
Leigh Peterson, Peter Smith, Chunqin Deng
Filed: 16 Apr 21
Utility
Stable treprostinil prodrugs
28 Nov 23
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Kenneth Robert Phares, Hitesh Batra, Liang Guo
Filed: 13 Dec 21
Utility
Process to Prepare Treprostinil, the Active Ingredient In Remodulin®
26 Oct 23
This present invention relates to an improved process to prepare prostacyclin derivatives.
Hitesh BATRA, Sudersan M. TULADHAR, Raju PENMASTA, David A. WALSH
Filed: 28 Jun 23
Utility
Prodrugs of treprosiinil
24 Oct 23
Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
Hitesh Batra, Liang Guo, Patrick Poisson, Sri Harsha Tummala, Elizabeth Ann Harris
Filed: 8 Jun 21
Utility
Treatment for interstitial lung disease
22 Aug 23
Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.
Leigh Peterson, Peter Smith, Chunqin Deng
Filed: 16 Apr 21
Utility
Treprostinil Prodrugs
17 Aug 23
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Ken PHARES, Hitesh BATRA, Liang GUO, Adam Marc SILVERSTEIN
Filed: 28 Apr 23
Utility
Multitransgenic Pigs Comprising Ten Genetic Modifications for Xenotransplantation
17 Aug 23
The present invention provides transgenic animals (e.g., transgenic porcine animals), organs, tissues, and cells derived from the transgenic animals that are particularly useful for xenotransplantation therapies.
Maria Kokkinaki, Kasinath V. Kuravi
Filed: 19 Sep 22
Utility
Process to prepare treprostinil, the active ingredient in Remodulin®
15 Aug 23
This present invention relates to an improved process to prepare prostacyclin derivatives.
Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
Filed: 7 Oct 19
Utility
Synthesis of Esuberaprost Prodrugs
25 May 23
Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.
Hitesh BATRA, Liang GUO
Filed: 23 Jan 23
Utility
Enhancement of MSC Immunomodulatory Properties by Treprostinil
4 May 23
Provided are methods for treating or preventing vasculopathy comprising administering to a subject in need thereof, ac composition comprising a mesenchymal stem cell (MSC), or a part of a culture medium that has been in contact with the MSC and comprises one or more components of the MSC, or an exosome derived from the MSC.
Roger Marquez ILAGAN, Sarah HOGAN, John B. CHEADLE
Filed: 29 Dec 22
Utility
Treprostinil prodrugs
25 Apr 23
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Kenneth Robert Phares, Hitesh Batra, Liang Guo
Filed: 24 Aug 20
Utility
Parenteral Formulations of Treprostinil
13 Apr 23
The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions.
Michael WADE
Filed: 31 Aug 22
Utility
Systems and Methods for Tissue Evaluation
16 Mar 23
Systems and methods are provided for evaluating a tissue that utilize a resistance to represent pressure of a fluid or gas passing through the tissue and a capacitance to represent compliance of the tissue.
Thomas Petersen, Jeffrey Soohoo, Blair Dodson, Joseph Papu, Joanna Peterschmitt
Filed: 13 Sep 22
Utility
Method to Obtain Cells from Lung Tissue
16 Mar 23
A method is disclosed for separating cells from a lung.
Benjamin Rusche, Ashleigh Casey, Jennifer Michaux, Laila Roudsari, Ashley R. Dockham
Filed: 24 Aug 22
Utility
Treprostinil Administration by Inhalation
2 Mar 23
Treprostinil can be administered using a metered dose inhaler.
Horst OLSCHEWSKI, Robert ROSCIGNO, Lewis J. RUBIN, Thomas SCHMEHL, Werner SEEGER, Carl STERRITT, Robert VOSWINCKEL
Filed: 17 Oct 22
Utility
System and Method for Maintaining Organ Viability
23 Feb 23
A system comprises a fluid supply, a pressure regulator, a pressure valve, and a vent assembly.
Randolph Vernon Monteiro Shelton, Jeffrey Robert SooHoo, Simone Julie Gregor
Filed: 17 Aug 22