93 patents
Page 3 of 5
Utility
Treprostinil Administration by Inhalation
13 Jan 22
Treprostinil can be administered using a metered dose inhaler.
Horst OLSCHEWSKI, Robert ROSCIGNO, Lewis J. RUBIN, Thomas SCHMEHL, Werner SEEGER, Carl STERRITT, Robert VOSWINCKEL
Filed: 27 Sep 21
Utility
Genetically-engineered Mesenchymal Stem Cells Overexpressing Aoah and Uses Thereof
13 Jan 22
Genetically-modified mesenchymal stem cells (MSCs) overexpressing an acyloxyacyl hydrolase (AOAH) polypeptide, such as MSCs comprising a recombinant nucleic acid encoding the AOAH polypeptide, are described.
Michael CALLAHAN, Shirley H.J. MEI, Yan WANG, Maria FLORIAN, Katelynn ROWE, Chyan-jang LEE
Filed: 29 Oct 19
Utility
Prodrugs of Treprostinil
9 Dec 21
Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
Hitesh BATRA, Liang GUO, Patrick POISSON, Sri Harsha TUMMALA, Elizabeth Ann HARRIS
Filed: 8 Jun 21
Utility
Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
23 Nov 21
The present invention provides certain donor animals, tissues and cells that are particularly useful for xenotransplantation therapies.
David Ayares
Filed: 13 Aug 13
Utility
Synthesis of Esuberaprost Prodrugs
18 Nov 21
Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.
Hitesh BATRA, Liang GUO
Filed: 17 Oct 19
Utility
Porcine animals lacking expression of functional alpha 1, 3 galactosyltransferase
16 Nov 21
The present invention is a porcine animal, tissue, organ, cells and cell lines, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha1,3GT).
Carol J. Phelps, David L. Ayares
Filed: 26 Feb 18
Utility
Structural Features of a Vehicle Having Utility to Transport High Value Things
4 Nov 21
An assembly, by way of example, an aircraft, including an aircraft motor apparatus including at least one motor located within a protective structure, the protective structure having movable sub-structure components, wherein the portion of the aircraft motor apparatus is configured to move the movable sub-structure components to increase or decrease airflow through the protective structure.
Ty Christopher Sauer
Filed: 29 Apr 21
Utility
Treatment for Interstitial Lung Disease
28 Oct 21
Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.
Leigh Peterson, Peter Smith, Chunqin Deng
Filed: 16 Apr 21
Utility
Controlled Release Pharmaceutical Formulations
14 Oct 21
Peter LAING
Filed: 10 May 21
Utility
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
12 Oct 21
Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin.
Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
Filed: 21 Sep 18
Utility
Ungulates with genetically modified immune systems
10 Aug 21
The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci.
Kevin Wells, David Ayares
Filed: 4 Mar 19
Utility
Inhalation Formulations of Treprostinil
17 Jun 21
The present invention describes novel methods for using Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of ischemic lesions, such as digital ulcers, in subjects with scleroderma (including systemic sclerosis), Buerger's disease, Raynaud's disease, Raynaud's phenomenon and/or other conditions that cause such lesions.
Michael WADE
Filed: 25 Feb 21
Utility
Salts of Treprostinil
17 Jun 21
Provided are novel treprostinil salts as well as methods for making treprostinil salts.
Hitesh BATRA, Vijay SHARMA, Sanmin YANG, Yi ZHANG
Filed: 30 Nov 20
Utility
Extracellular Vesicles and Their Uses
10 Jun 21
Provided are methods for isolating potent extracellular vesicle populations from mesenchymal stem cells.
Roger Ilagan, Sarah Hogan, John Cheadle, Carolina Papu
Filed: 2 Dec 20
Utility
Extracellular Vesicles with Enhanced Potency
27 May 21
Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.
Sarah HOGAN, Roger Marquez ILAGAN, Maria Pia RODRIGUEZ, Carolina MEDRANO, John CHEADLE
Filed: 1 Feb 21
Utility
Method for Purifying Antibodies
13 May 21
Disclosed here includes a method for purifying a biologic composition, comprising diafiltering the biologic composition into a composition comprising phosphate buffered saline (PBS) to obtain a purified composition.
David Meh, Timothy Atolagbe, G. Mark Farquharson, Samir Shaban, Mary Koleck, George Mitra
Filed: 21 Jan 21
Utility
Controlled release pharmaceutical formulations
11 May 21
Peter Laing
Filed: 29 Oct 19
Utility
Treprostinil Prodrugs
29 Apr 21
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Ken PHARES, Hitesh BATRA, Liang GUO, Adam Marc SILVERSTEIN
Filed: 4 Jan 21
Utility
Extracellular vesicles with enhanced potency
16 Mar 21
Provided are methods for isolating potent extracellular vesicle or exosome populations from mesenchymal stromal cells, and the use of the isolated extracellular vesicles or exosomes in treating vasculopathy, including pulmonary hypertension, bronchopulmonary dysplasia, and disease and conditions associated with mitochondrial dysfunction.
Sarah Hogan, Roger Marquez Ilagan, Maria Pia Rodriguez, Carolina Medrano, John Cheadle
Filed: 1 May 18
Utility
Compounds and methods for delivery of prostacyclin analogs
16 Mar 21
This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
Ken Phares
Filed: 23 Jul 19