37 patents
Utility
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
12 Dec 23
Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin.
Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
Filed: 8 Sep 21
Utility
Treatment of pulmonary arterial hypertension with prostacyclin-treated endothelial progenitor cells
12 Dec 23
The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.
Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
Filed: 16 Oct 20
Utility
Treatment for interstitial lung disease
28 Nov 23
Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.
Leigh Peterson, Peter Smith, Chunqin Deng
Filed: 16 Apr 21
Utility
Stable treprostinil prodrugs
28 Nov 23
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Kenneth Robert Phares, Hitesh Batra, Liang Guo
Filed: 13 Dec 21
Utility
Prodrugs of treprosiinil
24 Oct 23
Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.
Hitesh Batra, Liang Guo, Patrick Poisson, Sri Harsha Tummala, Elizabeth Ann Harris
Filed: 8 Jun 21
Utility
Treatment for interstitial lung disease
22 Aug 23
Methods of treating of interstitial lung disease, reducing pulmonary function decline in a subject with interstitial lung disease (ILD), and increasing forced vital capacity (FVC) in a subject suffering from ILD are provided, wherein the methods include administration of treprostinil.
Leigh Peterson, Peter Smith, Chunqin Deng
Filed: 16 Apr 21
Utility
Process to prepare treprostinil, the active ingredient in Remodulin®
15 Aug 23
This present invention relates to an improved process to prepare prostacyclin derivatives.
Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
Filed: 7 Oct 19
Utility
Treprostinil prodrugs
25 Apr 23
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
Kenneth Robert Phares, Hitesh Batra, Liang Guo
Filed: 24 Aug 20
Utility
Enhancement of MSC immunomodulatory properties by treprostinil
7 Feb 23
Provided are methods for treating or preventing vasculopathy comprising administering to a subject in need thereof , ac composition comprising a mesenchymal stem cell (MSC), or a part of a culture medium that has been in contact with the MSC and comprises one or more components of the MSC, or an exosome derived from the MSC.
Roger Marquez Ilagan, Sarah Hogan, John B. Cheadle
Filed: 23 Oct 17
Utility
Size-efficient drug-delivery device
7 Feb 23
A drug-delivery device comprising a drug-reservoir assembly, displacement-generating actuator, and drug administration unit is described, wherein the drug-reservoir assembly comprises at least one flexible wall and a constraining ring, such that the displacement generated by the actuator collapses a flexible wall of the assembly expelling the drug contents of the drug-reservoir towards said drug administration means.
Nir Rotem, Keren Fradkin, Jonathan Goldstein
Filed: 29 Oct 18
Utility
Synthesis of esuberaprost prodrugs
24 Jan 23
Provided are novel prodrugs of esuberaprost and pharmaceutical compositions thereof, as well as methods of making and methods of using these prodrugs.
Hitesh Batra, Liang Guo
Filed: 17 Oct 19
Utility
Drug delivery device
3 Jan 23
The present application provides a self-powered drug-delivery device.
Amir Genosar, Doron Aurbach, Elena Markevich, Grigory Salitra, Jonathan Goldstein, Mikhail Levi, Niles Fleischer, Yehuda Bachar, Yossi Aldar
Filed: 6 Aug 20
Utility
Aerosol delivery device and method for manufacturing and operating the same
5 Jul 22
An adjustable aerosol delivery device includes an active liquid container, a carrier liquid container, a piezo disc mounted with a flexible gasket relative to the carrier liquid container, an oscillator configured to generate an ultrasonic wave that causes the piezo disc to oscillate and transmit the oscillations through the carrier liquid to the active liquid to cause at least a portion of the active liquid to become an aerosol, a bushing fixed relative to the carrier liquid container via a fixing portion that conforms to and mates with an entire perimeter of a fixing section of the bushing, and a fastener extending through the piezo disc housing and into the bushing.
Doug Biette
Filed: 15 Jul 20
Utility
Treprostinil administration by inhalation
14 Jun 22
Treprostinil can be administered using a metered dose inhaler.
Horst Olschewski, Robert Roscigno, Lewis J. Rubin, Thomas Schmehl, Werner Seeger, Carl Sterritt, Robert Voswinckel
Filed: 27 Sep 21
Utility
Compounds and methods for delivery of prostacyclin analogs
5 Apr 22
This invention pertains generally to prostacyclin formulations and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis.
Ken Phares
Filed: 6 Oct 21
Utility
Salts of treprostinil
1 Feb 22
Provided are novel treprostinil salts as well as methods for making treprostinil salts.
Hitesh Batra, Vijay Sharma, Sanmin Yang, Yi Zhang
Filed: 30 Nov 20
Utility
Synthesis of intermediates for producing prostacyclin derivatives
18 Jan 22
Hitesh Batra, Sudersan M. Tuladhar, David A. Walsh
Filed: 12 Aug 20
Utility
Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
23 Nov 21
The present invention provides certain donor animals, tissues and cells that are particularly useful for xenotransplantation therapies.
David Ayares
Filed: 13 Aug 13
Utility
Porcine animals lacking expression of functional alpha 1, 3 galactosyltransferase
16 Nov 21
The present invention is a porcine animal, tissue, organ, cells and cell lines, which lack any expression of functional alpha 1,3 galactosyltransferase (alpha1,3GT).
Carol J. Phelps, David L. Ayares
Filed: 26 Feb 18
Utility
Treatment of vasculopathy with prostacyclin and mesenchymal stem cells
12 Oct 21
Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin.
Roger Jeffs, Thomas Petersen, Roger M. Ilagan, Michael Wade
Filed: 21 Sep 18