121 patents
Page 4 of 7
Utility
Polymorphs of Pyrimidine Cyclohexyl Glucocorticoid Receptor Modulators
25 Nov 21
The present invention provides crystalline forms of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.
Hazel Joan HUNT, Lorraine DONAGHY, Keith LORIMER, Nathan Jay DIXON, Jeffrey Mark DENER
Filed: 5 May 21
Utility
Optimizing mifepristone levels for Cushing's patients
16 Nov 21
The present invention provides a method for optimizing levels of mifepristone in a patient suffering from Cushing's syndrome.
Joseph Belanoff, Coleman Gross
Filed: 5 May 20
Utility
Therapeutic Uses of Relacorilant, a Heteroaryl-ketone Fused Azadecalin Glucocorticoid Receptor Modulator
4 Nov 21
Andreas Moraitis
Filed: 9 Jun 21
Utility
Method for Differentially Diagnosing Acth-dependent Cushing's Syndrome
7 Oct 21
This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome.
Andreas G. Moraitis
Filed: 21 Jun 21
Utility
Treatment of muscular dystrophy
31 Aug 21
The present invention resides in the discovery that glucocorticoid receptor antagonists are effective for treating muscular dystrophy including type 1 or type 2 myotonic dystrophy.
Joseph Belanoff
Filed: 26 May 11
Utility
Pyrimidine Cyclohexenyl Glucocorticoid Receptor Modulators
5 Aug 21
The present invention provides a class of pyrimidinedione cyclohekenyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
Hazel HUNT, Damien Francis Philippe CREPIN, Joseph Thomas HILL-COUSINS, Thomas Matthew BAKER, Lorna DUFFY
Filed: 3 Jun 19
Utility
Method for differentially diagnosing ACTH-dependent Cushing's syndrome
27 Jul 21
This invention provides for an improved method for differentially diagnosing ACTH-dependent Cushing's syndrome.
Andreas G. Moraitis
Filed: 21 Nov 19
Utility
Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
13 Jul 21
Andreas Moraitis
Filed: 21 Feb 20
Utility
Use of Glucocorticoid Receptor Modulators to Potentiate Checkpoint Inhibitors
8 Jul 21
This invention provides a method that combines a checkpoint inhibitor and a glucocorticoid receptor modulator to treat cancer, e.g., a checkpoint inhibitor sensitive cancer.
Hazel Hunt
Filed: 23 Mar 21
Utility
Use of glucocorticoid receptor modulators in the treatment of catecholamine-secreting tumors
29 Jun 21
Novel methods of treating tumors, including neuroendocrine tumors (NET), such as a catecholamine-secreting tumor (CST), are disclosed.
Andreas Moraitis
Filed: 8 Mar 18
Utility
Methods for Shrinking Pituitary Tumors
17 Jun 21
Andreas Moraitis
Filed: 25 Feb 21
Utility
Methods of Treating Antipsychotic-Induced Weight Gain with Miricorilant
17 Jun 21
Methods of Treating Antipsychotic-Induced Weight Gain with Miricorilant Methods and compositions for treating a subject at risk of, or suffering from antipsychotic-induced weight gain are disclosed.
Ada Lee, Joseph Belanoff, Hazel Hunt
Filed: 11 Dec 20
Utility
Heteroaryl-ketone Fused Azadecalin Glucocorticoid Receptor Modulators
10 Jun 21
The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
Hazel Hunt, Tony Johnson, Nicholas Ray, Iain Walters
Filed: 12 Jan 21
Utility
Octahydro Fused Azadecalin Glucocorticoid Receptor Modulators
13 May 21
The present invention provides octahydro fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
Hazel Hunt, Iain Walters, Benoit Gourdet
Filed: 12 Jan 21
Utility
Use of Glucocorticoid Receptor Antagonists for the Treatment of Amyotrophic Lateral Sclerosis
6 May 21
The invention generally pertains to the discovery that agents capable of inhibiting the binding of cortisol to its receptor can be used in methods for treating patients diagnosed with Amyotrophic Lateral Sclerosis (ALS).
Joseph K. Belanoff
Filed: 16 Oct 20
Utility
Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
13 Apr 21
The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
Hazel Hunt, Tony Johnson, Nicholas Ray, Iain Walters
Filed: 13 Sep 19
Utility
Glucocorticoid Receptor Modulators to Treat Cervical Cancer
25 Mar 21
Methods for treating a subject having a cancerous tumor are disclosed.
Hazel Hunt
Filed: 2 Dec 20
Utility
Fatty Liver Disease Treatment Using Glucocorticoid and Mineralocorticoid Receptor Antagonists
25 Mar 21
The present invention provides treatment of fatty liver disease using a class of pyrimidinedione cyclohexyl compounds.
Joseph K. Belanoff, Hazel Hunt, Onno C. Meijer, José van den Heuvel
Filed: 3 Dec 20
Utility
Methods for shrinking pituitary tumors
16 Mar 21
Andreas Moraitis
Filed: 8 Nov 19
Utility
Systems and methods of treatment using intervention and tasking determination
16 Mar 21
Devices, systems, and methods for use in managing patient treatments utilizing pharmaceutical or therapeutic compounds.
Steven Lo, David Penake, John Lyons, Kate Tully, Katherine Waidner
Filed: 24 May 18