451 patents
Utility
Polymerase Mutants and Use with 3'-OH Unblocked Reversible Terminators
18 Jan 24
Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3′-OH unblocked reversible terminators.
Michelle Cayouette, Jeffrey Fox, Connie Hansen, Holly Hogrefe, Weidong Wu
Filed: 11 Sep 23
Utility
Methods for Sequencing Polynucleotide Fragments from Both Ends
18 Jan 24
The present invention relates to preparation, sequencing and analysis of a sequencing library of adaptor-tagged fragments, wherein the fragments have different orientations relative to a sequencing adaptor.
David Taussig, Israel Steinfeld, Nicholas M Sampas, Brian Jon Peter
Filed: 10 Dec 20
Utility
Hybridization Compositions and Methods
18 Jan 24
The invention provides methods and compositions for hybridizing at least one molecule to a target.
Steen Hauge Matthiesen
Filed: 22 Aug 23
Utility
Compositions and Methods for Genomic Dna and Gene Expression Analysis In Single Cells
11 Jan 24
Provided herein are compositions and methods to assess the genomic landscape of fixed cells using light activated oligonucleotides that can be directed to the nucleus, mitochondria, or cytoplasm of fixed cells and that, upon activation, can be extended for in situ copying of nuclear single-stranded DNA (i.e., open chromatin), open mitochondrial DNA, and/or cytoplasmic RNA into barcoded complementary DNA.
James EBERWINE, Jae-Hee LEE, Jifen LI, Stephen FISHER, Youtao LU, Junhyong KIM, Jai-Yoon SUL, Jinchun WANG, Mimi HEALY
Filed: 15 Jun 23
Utility
Analysis of Mobile Phase Supply from Mobile Phase Container
11 Jan 24
In a sample separation apparatus for separating a fluidic sample, a mobile phase container is identified by determining a weight and volume characteristic of the mobile phase container, and identifying the mobile phase container based on a comparison of the determined weight and volume characteristic of the mobile phase container with a pre-known reference weight and volume characteristic of one or more reference mobile phase containers with pre-known identity.
Bettina Schuhn, Uwe Effelsberg, Manuel van Venrooy, Matthias Kamuf
Filed: 21 Sep 23
Utility
Analysis of Mobile Phase Supply from Mobile Phase Container
11 Jan 24
In a sample separation apparatus for separating a fluidic sample using a mobile phase provided from at least one mobile phase container, a method of determining a density of the mobile phase includes determining a weight and volume reduction behavior according to which weight and volume of mobile phase in a mobile phase container are reduced during conveying mobile phase from the mobile phase container in the sample separation apparatus.
Bettina Schuhn, Uwe Effelsberg, Manuel van Venrooy, Matthias Kamuf
Filed: 21 Sep 23
Utility
Gas Chromatography Systems and Methods with Diagnostic and Predictive Module
11 Jan 24
The present invention provides a gas chromatography system (GC) including a GC column configured for a chromatographic separation of a sample comprising one or more analytes, a GC detector connected to the exit of the GC column, and a controller connected to the GC system.
Simone Novaes-Card, Brian David Fitz, Steven Kirk, Joseph D'Alessio, Brent Casper
Filed: 16 Nov 21
Utility
Testing a Sampling Unit Fluidically Coupled to a Source
11 Jan 24
A sampling unit is fluidically coupled to a source.
Dominik Ruf, Thomas Ortmann
Filed: 19 Nov 21
Utility
Universal Multi-detection System for Microplates with Confocal Imaging
4 Jan 24
An apparatus for optically analyzing a sample may include an imaging subsystem that images the sample, one or more analyzing subsystems that analyze the sample including a confocal imaging subsystem, a temperature control subsystem that controls a temperature of the atmosphere within the apparatus, a gas control subsystem that controls a composition of the atmosphere within the apparatus, and a control module that controls the various subsystems of the apparatus.
Ross Marcel PIETTE, Xavier Francois Patrick AMOURETTI, Caleb Alan FOSTER, Benjamin Jon KNIGHT, Peter Brent KNOX, Ben Edward NORRIS, James Donald PIETTE, Richard Niles SEARS, Matthew Arthur STILES, Oleg Nikolaevich ZIMENKOV
Filed: 2 Dec 21
Utility
Solutions of quaternary and tertiary ammonium cation detergents to denature proteins, and kits for making them
2 Jan 24
Ammonium cation detergents comprising a quaternary or tertiary ammonium cation can be used as detergents to denature proteins and are particularly useful in denaturing glycoproteins or glycopeptides prior to enzymatic deglycosylation.
Michael J. Kimzey, Francis T. Haxo, Vaishali Sharma
Filed: 10 Aug 21
Utility
Load Adapter for Improved Packing Bed Stability
28 Dec 23
In some examples, a load adapter may include a body including an elongated shaft that includes an inlet passage that is in fluid communication with at least one outlet hole.
Norwin Rolf Leonhard VON-DOEHREN, Peter Van-Keulen, Roman Van-Keulen
Filed: 22 Jun 23
Utility
Chimeric Anti-human Braf V600E Antibodies and Methods for Making and Using Them
28 Dec 23
In alternative embodiments, provided are chimeric or recombinant anti-human BRAF V600E antibodies, including products of manufacture and kits comprising them, and methods for making and using them, including for example their use in the detection or diagnosis of a cancer or other condition.
Morten Draeby SORENSEN, Kirsten HOFF
Filed: 15 Nov 21
Utility
Guide Rna with Chemical Modifications
28 Dec 23
The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
Daniel E. RYAN, Douglas J. DELLINGER, Jeffrey R. SAMPSON, Robert KAISER, Joel MYERSON
Filed: 9 Jun 23
Utility
Immunohistochemistry (Ihc) Protocols and Methods for Diagnosing and Treating Cancer
28 Dec 23
In alternative embodiments, provided are immunohistochemistry (IHC) methods for determining and scoring reproducibly the extent of expression of the protein carcinoembryonic antigen-related cell adhesion molecule 5, or CEACAM5, in a tissue sample.
Sara ALVAREZ, Quyen NGUYEN, Nichole LAPOINTE, Michael DIMAIO, Mariana CAJAIBA, Russell A BALDOCCHI
Filed: 9 Jun 23
Utility
Electric Field Aided Sample Preparation
21 Dec 23
The present methods and apparatus apply an electric field to a sample in order to prepare it for analysis.
Adrienne McCampbell, Victor Lim, Sean Nasri, Brian Phillip Smart
Filed: 30 Jul 21
Utility
Method and system for implementing augmented reality (AR)-based assistance within work environment
19 Dec 23
Novel tools and techniques are provided for implementing augmented reality (AR)-based assistance within a work environment.
Amir Ben-Dor, Elad Arbel, Richard Workman, Victor Lim
Filed: 18 Jul 22
Utility
Device Including Transparent Polymer with Hydrophilic Coating, and Method of Making Same
14 Dec 23
A device, including a hydrophilic layer on a portion of an inner surface of a transparent polymer forming a body; wherein the hydrophilic layer includes a sulfonated inner surface of the transparent polymer, a silica, a silicon oxycarbide, an O2 plasma treatment of the transparent polymer, or a combination thereof.
Elizabeth CARR, Frank STRELLER, Li-Chih HU, David Michael LYNCH, Richard CLOSSER
Filed: 27 Mar 23
Utility
Headspace Eliminating Microtiter Plate Lid and Method of Optically Measuring Well Oxygen Concentration Through the Lid
7 Dec 23
An implement for eliminating headspace in the testing space(s) (T9 or MPWell) of a test tube (T) or microtiter plate (MP), and methods of using such implements to measure oxygen concentration in a test sample.
Ian M. Hayes, James N. Hynes
Filed: 21 Aug 23
Utility
Fluid Pump with Integrated Cowling and Discharge Muffler
7 Dec 23
A discharge muffler for a fluid pump is formed by a cowling and a muffler insert configured to be removably inserted into a muffler receptacle of the cowling.
Vannie Lu, George Galica
Filed: 7 Jun 22
Utility
Hybridization compositions and methods
5 Dec 23
The invention provides methods and compositions for hybridizing at least one molecule to a target.
Charles M. Hansen, Steen Hauge Matthiesen, Kenneth H. Petersen, Tim Svenstrup Poulsen
Filed: 13 Sep 21