451 patents
Page 10 of 23
Utility
Filter Assemblies, Depth Indicators, Torque-limiting Fittings, Torque-indicating Fittings, and Systems Incorporating the Same
23 Jun 22
In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter.
Alan D. LOUX, Lucas SERGE, Manuel VAN-VENROOY, Thomas HARRISON, Matthias KAMUF
Filed: 9 Mar 22
Utility
Chemically Modified Guide Rnas for Crispr/cas-mediated Gene Correction
23 Jun 22
Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell.
Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
Filed: 14 Mar 22
Utility
Filter Assemblies, Depth Indicators, Torque-limiting Fittings, Torque-indicating Fittings, and Systems Incorporating the Same
23 Jun 22
In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter.
Alan D. Loux, Lucas Serge, Manuel Van-Venrooy, Thomas Harrison, Matthias Kamuf
Filed: 9 Mar 22
Utility
Compositions Comprising Chemically Modified Guide Rnas for Crispr/cas-mediated Editing of HBB
23 Jun 22
Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell.
Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
Filed: 14 Mar 22
Utility
Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
14 Jun 22
A system for monitoring cell-substrate impedance of excitable cells at millisecond time resolution and methods of assessing cell beating by monitoring cell-substrate impedance of beating cells at millisecond time resolution.
Xiaobo Wang, Yama A. Abassi, Biao Xi, Wen Fu Zhang, Xiao Xu
Filed: 3 Jan 20
Utility
Ion pump shield
7 Jun 22
An ion pump with a housing enclosing an interior, a gas inlet having a through-hole extending into the interior of the ion pump, at least one cathode, at least one anode positioned in proximity to the at least one cathode, a magnet disposed on an opposite side of the at least one cathode from the anode, and a blocking shield disposed between the gas inlet and the at least one cathode.
Cristian Maccarrone, Chiara Paolini, Enrica Carbonero, Paolo Manassero
Filed: 18 Dec 19
Utility
Vaccum Degassing Using Electroactive Material
2 Jun 22
A degasser for at least partially degassing a gas-containing liquid, in particular for a sample separation device, includes a liquid accommodation volume for accommodating the gas-containing liquid during degassing, a negative pressure chamber in which a negative pressure, compared to the liquid accommodation volume, is to be generated, a gas permeable membrane separating the liquid accommodation volume from the negative pressure chamber and arranged so that ultrasound forces at least part of gas of the gas-containing liquid to move through the membrane by a combination of the negative pressure and the ultrasound, and an ultrasound source including an electroactive material and configured for generating ultrasound for actuating the gas-containing liquid and/or the gas permeable membrane.
Clemens Plachetka, Tony Ziegler, Joachim-Richard Wagner
Filed: 30 Nov 21
Utility
Vacuum Pump with Elastic Spacer
2 Jun 22
A vacuum pump includes a housing, a rotatable shaft extending in an axial direction within the housing, a first pumping arrangement including a first stator arrangement and a first rotor arrangement, and a second pumping arrangement including a second stator arrangement and a second rotor arrangement.
Federico Terminio, Simone Cau
Filed: 1 Dec 21
Utility
System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
31 May 22
Devices, systems and methods for monitoring excitable cells, such as cardiomyocytes, on microelectrode arrays that couple the electro-stimulation of excitable cells to induce or regulate cardiomyocyte beating and the simultaneous measurement of impedance and extracellular recording to assess changes in cardiomyocyte beating, viability, morphology or electrophysical properties in response to a plurality of treatments.
Xiaobo Wang, Wei Ouyang, Nan Li, Tianxing Wang, Xiaoyu Zhang, Xiao Xu, Yama A. Abassi
Filed: 19 Dec 19
Utility
Branching off fluidic sample with low influence on source flow path
31 May 22
A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.
Thomas Ortmann, Daniel Thielsch
Filed: 10 May 19
Utility
Compositions and Methods for Performing Hybridizations with No Denaturation
26 May 22
The invention provides methods and compositions for hybridizing at least one molecule to a target.
Steen H. Matthiesen
Filed: 28 Sep 21
Utility
UV-absorbance multichannel capillary electrophoresis system
24 May 22
A capillary electrophoresis system includes a capillary reservoir.
Michael Stebniski, Bruce R. Boeke, Martin Chris Foster, Scott Stueckradt, Thomas J. Kurt
Filed: 15 Aug 17
Utility
Multi frequency LC resonator topologies applicable to mass spectrometer radio-frequency drive systems
24 May 22
In one embodiment, a power source for providing high-voltage radio-frequency (RF) energy to an instrument such as a mass spectrometer includes an RF power amplifier having an output, an oscillating RF signal generator configured to provide first and second RF signals respectively oscillating at first and second frequencies to the RF power amplifier, and a step-up circuit for magnifying the RF power amplifier output.
Michael Schoessow
Filed: 8 Apr 20
Utility
Versatile Tube-free Jet for Gas Chromatography Detector
28 Apr 22
A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.
Edward D. MROZ, Heng HE
Filed: 13 Jan 20
Utility
Configuring an Injector for Emulating Operation of Another Injector
28 Apr 22
A configurable injector for injecting a fluidic sample in a separation path of a sample separation apparatus includes a sample accommodation volume for accommodating the fluidic sample to be injected into the separation path, a valve arrangement fluidically couplable with the separation path, fluidically coupled with the sample accommodation volume, and being controllable for injecting the fluidic sample into the separation path, an input interface configured for receiving input data indicative of an injection profile of an injector to be emulated by the configurable injector, and a control unit configured for controlling the configurable injector, in particular the valve arrangement, so that the configurable injector is operated in accordance with the injection profile to thereby emulate the injector to be emulated.
Thomas Ortmann
Filed: 14 Dec 18
Utility
Preparation of Tissue Sections Using Fluorescence-based Detection
21 Apr 22
The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample.
Kyle Schleifer, Kristin Briana Bernick, Adrienne Mccampbell, Nicholas M. Sampas, Victor Lim
Filed: 29 Dec 21
Utility
Sample Injection with Fluidic Connection Between Fluid Drive Unit and Sample Accommodation Volume
21 Apr 22
An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path.
Daniel Thielsch, Thomas Ortmann, Sam Wouters
Filed: 30 Dec 21
Utility
Chemically modified guide RNAs for CRISPR/CAS-mediated gene regulation
19 Apr 22
Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell.
Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
Filed: 3 Oct 17
Utility
Gas Leak Detector Cartridge
31 Mar 22
A gas leak detector cartridge includes a cartridge housing that is removably installed in a handheld device.
Chin-Seong Khor, Jon-Wen Tan, Heng-Dar Ling
Filed: 28 Sep 20
Utility
System and method for detecting multiple-excitation-induced light in a flow channel
29 Mar 22
A system for detecting signal components of light induced by multiple excitation sources including: a flow channel including at least two spatially separated optical interrogation zones; a non-modulating excitation source that directs a light beam of a first wavelength at a near constant intensity onto a first of the optical interrogation zones; a modulating excitation source that directs a light beam of a second wavelength with an intensity modulated over time at a modulating frequency onto a second of the optical interrogation zones; a detector subsystem comprising a set of detectors configured to detect light emitted from particles flowing through the at least two optical interrogation zones and to convert the detected light into a total electrical signal; and a processor that determines signal components from the light detected from each of the optical interrogation zones.
Nan Li, Jian Wu, Ye Chen, Tianxing Wang, Xiaobo Wang
Filed: 27 Mar 20