451 patents
Page 17 of 23
Utility
Full field visual-mid-infrared imaging system
4 Jan 21
An apparatus and method for generating images of specimens is disclosed.
Andrew Ghetler
Filed: 2 Apr 19
Utility
Fluid Mixing by Fluid Supply Lines with Line-specific Fluid Pumps for Liquid Chromatography
23 Dec 20
A liquid chromatography fluid supply apparatus, for providing a mixture of a plurality of different fluids as a mobile phase for a liquid chromatography sample separation apparatus, includes a plurality of supply lines, a plurality of fluid pumps, and a combining point.
Clemens Plachetka
Filed: 28 Feb 19
Utility
Precision high voltage power supply utilizing feedback through return side output
21 Dec 20
In one embodiment, a high voltage power supply includes a DC voltage input, a converter for converting a DC voltage at the DC voltage input to an AC voltage, a booster for boosting the AC voltage to a boosted AC voltage, a rectifier in DC isolation from the DC voltage input, the rectifier operable to convert the boosted AC voltage to a high DC voltage at an isolated rectifier output, a high voltage DC output for outputting the high DC voltage, a voltage control input, and an error circuit coupled to the voltage control input and operable to reduce variation in the high DC voltage by driving a return side of the isolated rectifier output in response to feedback based on the high DC voltage.
David Deford
Filed: 4 Jun 19
Utility
Room Temperature Methods for Preparing Biological Analytes
16 Dec 20
Reagents and methods for extracting and stabilizing metabolites at room temperature and methods in which metabolites and one or more of proteins, lipids and nucleic acids are extracted from a single sample in a unified workflow.
Genevieve Van de Bittner, James Alexander Apffel, Steven M. Fischer, Christine A. Miller, Kristin Briana Bernick
Filed: 13 May 20
Utility
Polychromator Systems and Methods
2 Dec 20
A polychromator system comprising: an optical element defining an aperture; a collimation mirror for receiving light via the aperture and reflecting substantially collimated light; at least a first dispersive optical component and a second dispersive optical component, each configured to disperse the substantially collimated light received from the collimation mirror by different amounts for different wavelengths and to provide cross-dispersed light having different wavelengths of light spaced along a first and second axis; and a focus mirror positioned to focus the cross-dispersed light onto a 2-D array detector to provide a plurality of aperture images of the aperture at a respective plurality of regions of the detector, each of the plurality of aperture images associated with a respective wavelength of the cross-dispersed light.
Sean M. Kent, Lindsay Buck
Filed: 1 May 18
Utility
Inductively coupled plasma mass spectrometry (ICP-MS) with improved signal-to-noise and signal-to-background ratios
30 Nov 20
In an inductively coupled plasma-mass spectrometry (ICP-MS) system, ions are transmitted into a collision/reaction cell.
Noriyuki Yamada, Erina Shimizu
Filed: 12 Mar 19
Utility
Use of Tri- and Tetra- Hydroxyl Quaternary Ammonium Compounds As Resolving Agents for Electrophoretic Separations
25 Nov 20
The present disclosure provides methods of improving the resolution of analytes by in electrophoretic separations using a gel by incorporating into the gel an effective amount of one or more tri- or tetra-hydroxyl quaternary ammonium compounds, or a mixture of such compounds.
Michael J. KIMZEY, Fielito U. LIMJAP, Francis T. HAXO, Sergey VLASENKO
Filed: 10 Jan 19
Utility
Stable Label Isotope Tracing for Untargeted Data
18 Nov 20
A method for analyzing samples utilizing stable label isotope tracing includes receiving mass spectrometry (MS) data generated by an MS system performing untargeted data acquisition on a plurality of samples, performing untargeted feature extraction on the unlabeled compound data to generate a data set of first extracted features, generating a plurality of empirical molecular formulas respectively corresponding to the first extracted features, performing targeted isotopologue extraction on the labeled compound data to generate a data set of second extracted features, wherein the targeted isotopologue extraction is based on the empirical molecular formula and retention time of each first extracted feature, and identifying one or more groups of isotopologues from the second extracted features.
Stephen P. Madden, Steven M. Fischer
Filed: 9 Apr 20
Utility
Systems and methods for tracking and providing workflow information
9 Nov 20
A tangible computer-readable storage device storing computer-executable program instructions that generate a user interface for displaying workflow information associated with a tissue specimen in a pathology laboratory.
Laura Chirica, Mats Grahn, Stephen Jones
Filed: 20 Aug 17
Utility
Temporary storage of sample portions for artefact-preventing fluid processing
9 Nov 20
In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while emptying, it is avoided to bring two respective ones of the sample sections, which have not left the sample source directly adjacent to one another, in contact with one another.
Herbert Anderer, Konstantin Shoykhet, Klaus Witt, Stephan Buckenmaier
Filed: 27 May 15
Utility
Methods, Devices, and Kits to Improve Reduction or Labeling of Carbohydrates
4 Nov 20
The present invention provides methods, devices, and kits to improve procedures for reducing carbohydrates, such as glycans released from glycoconjugates, or for labeling carbohydrates by reductive amination.
Andres GUERRERO NAVARRO
Filed: 16 Sep 19
Utility
Microfluidic Dielectrophoretic Droplet Extraction
4 Nov 20
A microfluidic apparatus for separating a droplet of an emulsion in a microfluidic environment is described.
Curt A. Flory, Dustin Chang
Filed: 29 Apr 19
Utility
MHC Multimers In Tuberculosis Diagnostics, Vaccine and Therapeutics
4 Nov 20
The present invention relates to MHC peptide complexes and uses thereof in the diagnosis of, treatment of or vaccination against a disease in an individual.
Jørgen SCHØLLER, Liselotte BRIX, Henrik PEDERSEN, Tina JAKOBSEN
Filed: 12 Feb 20
Utility
High Specificity Genome Editing Using Chemically Modified Guide RNAs
28 Oct 20
The present invention relates to guide RNAs having chemical modifications and their use in CRISPR-Cas systems.
Douglas J Dellinger, Daniel E Ryan, Subhadeep Roy, Jeffrey R Sampson
Filed: 14 Jul 20
Utility
Hybridization Compositions and Methods for Making and Using Compositions
28 Oct 20
The present disclosure relates to hybridization buffers for use in hybridization, for example, for use in in situ hybridization (ISH).
Jens Mollerup
Filed: 20 Apr 20
Utility
Injector with Fluid Supply and Mobile Phase Discharge
28 Oct 20
Injector (40) for injecting a fluidic sample into a mobile phase in a sample separation apparatus (10), the injector (40) comprising a main flow path (100) between a fluid drive (20) and a sample separation device (30), wherein the fluid drive (20) is adapted to drive the mobile phase and the sample separation device (30) is adapted to separate the fluidic sample that is injected into the mobile phase, a discharge device (104) for discharging an, in particular predetermined, amount of the mobile phase from the main flow path (100), and a supply device (102) for supplying an, in particular predetermined, amount of the fluidic sample and/or of a solvent into the main flow path (100), wherein the discharged amount and the supplied amount compensate each other at least partially.
Thomas Ortmann, Konstantin Shoykhet
Filed: 25 Oct 18
Utility
Branching Off Fluidic Sample with Low Influence on Source Flow Path
21 Oct 20
A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.
Thomas Ortmann, Daniel Thielsch, Dominik Ruf
Filed: 30 Jun 20
Utility
Method and System for Determining Integrated Metabolic Baseline and Potential of Living Cells
21 Oct 20
The current technology is related to methods for rapidly determining the metabolic baseline and potential of living cells.
David A. Ferrick, Brian Dranka
Filed: 29 Jun 20
Utility
Multi Frequency LC Resonator Topologies Applicable to Mass Spectrometer Radio Frequency Drive Systems
14 Oct 20
In one embodiment, a power source for providing high-voltage radio-frequency (RF) energy to an instrument such as a mass spectrometer includes an RF power amplifier having an output, an oscillating RF signal generator configured to provide first and second RF signals respectively oscillating at first and second frequencies to the RF power amplifier, and a step-up circuit for magnifying the RF power amplifier output.
Michael Schoessow
Filed: 7 Apr 20
Utility
Deep Learning Based Training of Instance Segmentation via Regression Layers
14 Oct 20
Novel tools and techniques are provided for implementing digital microscopy imaging using deep learning-based segmentation and/or implementing instance segmentation based on partial annotations.
Elad Arbel, Itay Remer, Amir Ben-Dor
Filed: 9 Apr 20