451 patents
Page 2 of 23
Utility
Sample injection with fluidic connection between fluid drive unit and sample accommodation volume
5 Dec 23
An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path.
Daniel Thielsch, Thomas Ortmann, Sam Wouters
Filed: 30 Dec 21
Utility
Column Depth Measuring Guide
30 Nov 23
A device, including a body including a first post and a second post positioned on opposite sides of a recessed area is disclosed.
Lucas SERGE, Wei J. SONG, Eileen HUANG, Olga SCHIKURSKI, Kathleen NOBLET
Filed: 25 May 22
Utility
Horizontally Adjustable Sample Taker for Dissolution Apparatus
30 Nov 23
A sampling device for taking sample from a vessel of a dissolution apparatus includes a sample taker configured to be movable within a horizontal plane when mounted at the vessel.
Alan Norman, Jonathan Mark Barnes
Filed: 9 Aug 23
Utility
Synthetic Generation of Immunohistochemical Special Stains
16 Nov 23
There is provided a computer implemented method for training a virtual stainer machine learning model, comprising: creating an imaging multi-record training dataset, wherein a record comprises: a first image of a sample of tissue of a subject stained with a removable stain, and a ground truth indicated by a second image of the sample of tissue of the subject stained with a permanent stain, and training a virtual stainer machine learning model on the imaging multi-record training dataset for generating a virtual image depicting the permanent stain in response to an input image depicting the removable stain.
Frederik AIDT
Filed: 17 Feb 23
Design
Column depth measuring guide
14 Nov 23
Lucas Serge, Wei J. Song, Eileen Huang, Olga Schikurski, Kathleen Noblet
Filed: 25 May 22
Design
Column depth measuring guide
14 Nov 23
Lucas Serge, Wei J. Song, Eileen Huang, Olga Schikurski, Kathleen Noblet
Filed: 25 May 22
Design
Column depth measuring guide
14 Nov 23
Lucas Serge, Wei J. Song, Eileen Huang, Olga Schikurski, Kathleen Noblet
Filed: 25 May 22
Design
Purging bottle
14 Nov 23
Olga Schikurski, Manuel Van-Venrooy, Tiantian Li
Filed: 28 Feb 23
Utility
Use of tri- and tetra-hydroxyl quaternary ammonium compounds as resolving agents for electrophoretic separations
14 Nov 23
The present disclosure provides methods of improving the resolution of analytes by in electrophoretic separations using a gel by incorporating into the gel an effective amount of one or more tri- or tetra-hydroxyl quaternary ammonium compounds, or a mixture of such compounds.
Michael J. Kimzey, Fielito U. Limjap, Francis T. Haxo, Sergey Vlasenko
Filed: 11 Jan 19
Utility
Stable label isotope tracing for untargeted data
14 Nov 23
A method for analyzing samples utilizing stable label isotope tracing includes receiving mass spectrometry (MS) data generated by an MS system performing untargeted data acquisition on a plurality of samples, performing untargeted feature extraction on the unlabeled compound data to generate a data set of first extracted features, generating a plurality of empirical molecular formulas respectively corresponding to the first extracted features, performing targeted isotopologue extraction on the labeled compound data to generate a data set of second extracted features, wherein the targeted isotopologue extraction is based on the empirical molecular formula and retention time of each first extracted feature, and identifying one or more groups of isotopologues from the second extracted features.
Stephen P. Madden, Steven M. Fischer
Filed: 10 Apr 20
Utility
Microfluidic Chip-based Droplet Processor
9 Nov 23
A microfluidic apparatus for forming one or more droplets of an aqueous fluid suspended in a non-aqueous fluid is described.
Curt A. FLORY, Dustin CHANG, Kelly KROEGER
Filed: 30 Jul 21
Utility
Anti-human LAG-3 Antibodies and Their Use In Immunohistochemistry (Ihc)
9 Nov 23
Provided are chimeric or recombinant antibodies (Ab), or antigen binding fragments thereof, or monomeric or dimeric antigen binding proteins, that can specifically bind to human LAG-3 polypeptides, including human LAG-3 polypeptides expressed on the surface of lymphocytes such as activated T cells that have infiltrated tumors or tumor infiltrating lymphocytes (TILs), and methods for making and using them.
Morten Draeby SORENSEN, Tine HAGEDORN-OLSEN
Filed: 24 Apr 23
Utility
Mixing fluid by combined axial motion and rotation of mixing body
7 Nov 23
A mixer for mixing a mobile phase in a sample separation device for separating a fluidic sample, wherein the mixer includes a fluid inlet for supplying the mobile phase to be mixed to a mixing volume, a movable body configured for rotating and axially moving in the mixing volume to thereby mix the mobile phase, and a fluid outlet for supplying the mixed mobile phase to a mobile phase consumer.
Clemens Plachetka, Manfred Berndt, Konstantin Shoykhet
Filed: 14 Jul 20
Utility
Room temperature methods for preparing biological analytes
7 Nov 23
Reagents and methods for extracting and stabilizing metabolites at room temperature and methods in which metabolites and one or more of proteins, lipids and nucleic acids are extracted from a single sample in a unified workflow.
Genevieve Van de Bittner, James Alexander Apffel, Steven M. Fischer, Christine A. Miller, Kristin Briana Bernick
Filed: 14 May 20
Utility
Multi-dimensional liquid chromatography with second dimension having a variable flow rate
7 Nov 23
A multi-dimensional liquid chromatography system includes first and second liquid chromatography systems.
Konstantin Shoykhet, Stephan Buckenmaier
Filed: 26 Aug 21
Utility
Chromatography Solvent Supply With Tubing Arm For Positioning a Tubing End
2 Nov 23
A solvent supply for a chromatography system includes a mobile phase drive and a separation unit.
Jan Lembcke, Dirk Arheidt, Gernot Klein
Filed: 16 Mar 21
Utility
Shaft Coupling
2 Nov 23
In some examples, a shaft coupling system may include a first shaft including a disc that is engageable by a second shaft to retain the second shaft with the first shaft when the second shaft is rotated in a first direction, and release the second shaft from the first shaft when the second shaft is rotated in a second direction that is opposite to the first direction.
Patrick Matz, Manuel Van Venrooy, Alan Norman
Filed: 30 Mar 23
Utility
Pressure-based Liquid Level Detection
2 Nov 23
Novel tools and techniques are provided for implementing liquid level detection, particularly, for implementing pressure-based liquid level detection, and, more particularly, for implementing pressure-based liquid level detection that takes into account presence of foam, wet septum seals on a container, and/or pressure changes caused by a partially sealed septum of a container.
Brian Sheldon, Michal Johannsen, Andy Wu
Filed: 9 Aug 21
Utility
Characterizing Quadrupole Transmitting Window In Mass Spectrometers
26 Oct 23
A quadrupole transmitting window applied by a quadrupole mass filter is characterized by a method that utilizes the noise band of a transmitted chemical noise ion signal.
Kai Chen, Kenneth R. Newton, Christian Wisner-Carlson
Filed: 26 Apr 22
Utility
Methods for Using Guide Rnas with Chemical Modifications
26 Oct 23
Provided herein are compositions and methods for inducing CRISPR/Cas-based editing of a target nucleic acid (e.g., target DNA or target RNA), or modulating the express of a target nucleic acid, in vitro or in a cell, using modified guide RNAs (gRNAs) that incorporate one or more chemically-modified nucleotides.
Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser
Filed: 14 Sep 22