451 patents
Page 5 of 23
Utility
Sample Injector With Metering Device Balancing Pressure Differences In An Intermediate Valve State
4 May 23
A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.
Bernd Glatz, Wolfgang Kretz
Filed: 21 Oct 22
Utility
Rotary Valve with Compensation Element to Compensate for Axial Misalignment
4 May 23
A valve, such as for a high performance chromatography system for separating components of a sample liquid introduced into a mobile phase, includes a rotor and a stator, wherein a flow path can be established or inhibited by a rotational movement of the rotor relative to the stator.
Armin Steinke
Filed: 2 Nov 22
Utility
Method and apparatus for measuring physiological properties of biological samples
2 May 23
The present disclosure relates to methods and apparatus for measuring of multiple physiological properties of biological samples, such as measuring biological flux.
Andrew C Neilson, Paul D McGarr
Filed: 6 Apr 17
Utility
Methods and Systems for Determining Metabolic Poise and Capacity of Living Cells
27 Apr 23
Disclosed herein are methods and systems for evaluating the bioenergetic poise and bioenergetic capacity of living cells in a single assay.
Maria Natalia Romero Filardo, James Niall Hynes
Filed: 11 Oct 22
Utility
Ion Activation and Fragmentation In Sub-ambient Pressure for Ion Mobility and Mass Spectrometry
27 Apr 23
An ion source may include an ionization chamber to be maintained at atmospheric-pressure.
Ruwan T. KURULUGAMA, Kenneth R. NEWTON
Filed: 16 Sep 22
Utility
Methods and Compositions for Multistage Primer Extension Reactions
27 Apr 23
Methods and compositions are described for multi-stage primer extension reactions such as multiplex polymerase chain reactions (PCR) and reverse transcriptase PCR.
Jinchun Wang, Jurgen Del Favero, Weidong Wu, Holly Hogrefe
Filed: 3 Feb 21
Utility
Dual Feedback Loop for Precision High Voltage Power Supply
27 Apr 23
A high-voltage (HV) power supply outputs an output voltage based on a control signal produced by a dual analog/digital feedback loop.
David Deford
Filed: 20 Dec 22
Utility
Label-free Monitoring of Excitation-contraction Coupling and Excitable Cells Using Impedance Based Systems with Millisecond Time Resolution
27 Apr 23
A system for monitoring cells, which includes a device for monitoring cell-substrate impedance, the device having a plurality of wells on a nonconductive substrate, where each of the plurality of wells has an electrode array fabricated on the substrate for measurement of cell-substrate impedance; an impedance analyzer that measures cell-substrate impedance from the plurality of wells; electronic circuitry with multiple analogue-to-digital conversion channels, where the electronic circuitry electrically connects the electrode arrays to the impedance analyzer such that the electrode arrays are electrically monitored at millisecond time resolution; and a software program that analyzes the measured cell-substrate impedance.
Xiaobo Wang, Yama A. Abassi, Biao Xi, Wen Fu Zhang, Xiao Xu
Filed: 23 Nov 22
Utility
Sample Separation Network with Simply Connectable Sample Separation Device
27 Apr 23
A sample separation network includes a server node, a plurality of client nodes coupled with the server node, a plurality of sample separation devices coupled with the server node, wherein each of the sample separation devices includes device-specific control software configured for controlling specifically the respectively assigned sample separation device, wherein at least one of the server node and the client nodes includes generic control software configured for generically controlling sample separation devices in a non-device-specific way, and wherein at least one of the server node and the client nodes and the sample separation devices is configured for loading device-specific control software from a sample separation device to at least one of the server node and the client nodes upon connection of said sample separation device to the sample separation network.
Thomas Romanowski, Frank Maar, Bruce James Dolby, Stefan Huber
Filed: 15 Mar 21
Utility
Synchronization of supply flow paths
25 Apr 23
A solvent supply system for supplying a composite includes a first supply path with a first pump unit, the first supply path being adapted for supplying a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply path with a second pump unit, the second supply path being adapted for supplying a second solvent to the mixing unit, the second pump unit operating periodically.
Klaus Witt, Konstantin Shoykhet
Filed: 17 May 21
Utility
Pressure decoupling fluid drive unit from flow path for pressure adjustment of sample accommodation volume
25 Apr 23
An apparatus for separating a fluidic sample includes a fluid drive arrangement including fluid drive units for driving a mobile phase along a flow path to a sample separation unit, a sample accommodation volume for accommodating the fluidic sample and selectively fluidically coupleable with or decoupleable from the flow path, and a control unit.
Konstantin Shoykhet
Filed: 6 Apr 18
Utility
Orthoester Compositions for Affinity Purification of Oligonucleotides
20 Apr 23
Compounds and methods for purifying oligonucleotides such as RNA and DNA.
Douglas J. DELLINGER, Joel MYERSON, Brian SMART
Filed: 14 Nov 22
Utility
Sample dispatching with fluidic sample retaining
18 Apr 23
A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit.
Thomas Ortmann, Thomas Glauner
Filed: 30 Jul 20
Utility
Inductively coupled plasma mass spectrometry (ICP-MS) with improved signal-to-noise and signal-to-background ratios
18 Apr 23
In an inductively coupled plasma-mass spectrometry (ICP-MS) system, ions are transmitted into a collision/reaction cell.
Noriyuki Yamada, Erina Shimizu
Filed: 30 Oct 20
Utility
Filter Assemblies, Depth Indicators, Torque-limiting Fittings, Torque-indicating Fittings, and Systems Incorporating the Same
13 Apr 23
In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter.
Alan D. LOUX, Lucas SERGE, Manuel VAN-VENROOY, Thomas HARRISON, Matthias KAMUF
Filed: 29 Jun 21
Utility
Bracketing Fluidic Sample Using Strong Solvent
13 Apr 23
A sample separation device for separating a fluidic sample includes a fluid drive for driving a mobile phase and the fluidic sample when injected in the mobile phase, a sample separation unit for separating the fluidic sample in the mobile phase, and a control unit configured for bracketing the fluidic sample between two mobile phase portions of the mobile phase.
Dwight Robert Stoll, Stephan Buckenmaier, Sascha Lege, Thomas Ortmann, Konstantin Shoykhet
Filed: 15 Mar 21
Design
Purging bottle
11 Apr 23
Olga Schikurski, Manuel Van-Venrooy, Tiantian Li
Filed: 15 Apr 21
Utility
Flow Cell for Sample Separation Apparatus with Protection Against Electromagnetic Stray Radiation
30 Mar 23
A flow cell, for detecting a fluidic sample separated by a sample separation apparatus, includes a cuvette, a flow channel formed at least partially in the cuvette and configured to enable a flow of the separated fluidic sample through the flow channel, an electromagnetic radiation inlet at which an excitation electromagnetic radiation beam is couplable into the cuvette, and an electromagnetic radiation outlet at which an emission electromagnetic radiation beam, generated by an interaction between the excitation electromagnetic radiation beam and the separated fluidic sample, is couplable out of the cuvette.
Daniell Malsch, Christoph Keppler, Bertram Beigel, Karsten Kraiczek
Filed: 26 Sep 22
Utility
Sample Injector with Sample Fluid Filtering
23 Mar 23
A sample injector is provided for a chromatography system that includes a mobile phase drive and a separation unit.
Blasius Nocon, Thomas Ortmann
Filed: 26 Feb 21
Utility
Guide RNAs with Chemical Modification for Prime Editing
23 Mar 23
Provided herein are compositions and methods for inducing CRISPR/Cas-based editing of a target nucleic acid (e.g., target DNA or target RNA) in vitro or in a cell, using modified prime editing guide RNAs (pegRNAs) that incorporate one or more chemically-modified nucleotides.
Daniel E. Ryan, Robert Kaiser, Douglas J. Dellinger
Filed: 12 Sep 22