451 patents
Page 7 of 23
Utility
Precision high voltage power supply with dual feedback loop
17 Jan 23
A high-voltage (HV) power supply outputs an output voltage based on a control signal produced by a dual analog/digital feedback loop.
David Deford
Filed: 27 Apr 21
Utility
Ligation-based Gene Editing Using Crispr Nickase
12 Jan 23
Disclosed are compositions and methods for gene editing.
Nicholas M. SAMPAS, David TAUSSIG
Filed: 17 Dec 20
Utility
Nstrument Component Organizer
12 Jan 23
In some examples, an organizer may include a plurality of inserts.
Shaouhan HU, Daniela Loraing, Olga Schikurski, Sascha Lege, Stephan Buckenmaier
Filed: 9 Jul 21
Utility
Orthoester compositions for affinity purification of oligonucleotides
10 Jan 23
Compounds and methods for purifying oligonucleotides such as RNA and DNA.
Douglas J. Dellinger, Joel Myerson, Brian Smart
Filed: 18 Feb 20
Utility
Molecular fabrication
10 Jan 23
Provided herein is a method for fabricating transformable or transfectable molecules that includes an assembly reaction containing a variety of pre-made cassettes possessing ends that hybridize to one another, transforming or transfecting said molecules into a desired host cell and then selecting a transformed/transfected host cell containing plasmid molecules composed of said the cassettes.
Jeffrey Carl Braman, Peter James Sheffield, Gavin Fischer
Filed: 28 Feb 20
Utility
Chromogenic Peroxidase Substrates
5 Jan 23
Chromogenic conjugates for color-based detection of targets are described.
Jesper Lohse, Mike Paw Maischnack Hansen
Filed: 10 Aug 22
Utility
Fluid Handling Using Receptacle Marking for Needle Positioning
5 Jan 23
A fluid handling unit is configured for handling a fluid contained or to be contained in a receptacle bearing a marking.
Hans-Peter Zimmermann
Filed: 1 Dec 20
Utility
Methods to improve reduction or labeling of carbohydrates
3 Jan 23
The present invention provides methods, devices, and kits to improve procedures for reducing carbohydrates, such as glycans released from glycoconjugates, or for labeling carbohydrates by reductive amination.
Andres Guerrero Navarro
Filed: 22 Mar 18
Utility
Use of transposase and Y adapters to fragment and tag DNA
27 Dec 22
Described herein is an adapter comprising a population of first oligonucleotides, a second oligonucleotide and a third oligonucleotide, wherein the first oligonucleotides, the second oligonucleotide and the third oligonucleotide are hybridized together to produce a complex that comprises: (i) a first end comprising a transposase recognition sequence, (ii) a central single-stranded region of variable sequence and (iii) a second end comprising sequences that are non-complementary.
Robert A. Ach, Nicholas M. Sampas, Brian Jon Peter
Filed: 7 Mar 19
Utility
Chemically modified guide RNAS for CRISPR/Cas-mediated gene regulation
27 Dec 22
Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell.
Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
Filed: 14 Mar 22
Utility
Deparaffinization of tissue utilizing electric field
13 Dec 22
Paraffin-embedded tissue is prepared removing paraffin from the tissue.
Adrienne Mccampbell, Victor Lim
Filed: 23 Apr 19
Utility
Sample injector with metering device balancing pressure differences in an intermediate valve state
6 Dec 22
A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.
Bernd Glatz, Wolfgang Kretz
Filed: 13 Aug 20
Utility
Sample injector with conduit tip penetrating into needle opening
6 Dec 22
A sample injector for a chromatography system is configured for injecting a sample fluid into a mobile phase, and includes a needle and a conduit.
Thomas Ortmann, Michael Lang, Blasius Nocon
Filed: 23 Apr 21
Utility
Synthetic silica as packing material in supported liquid extraction
29 Nov 22
In embodiments, a packing material for supported liquid extraction has a sorbent media that includes synthetic silica particles.
Kunqiang Jiang, Derick Lucas, Bruce Richter
Filed: 9 Apr 20
Utility
Ion guide with varying multipoles
29 Nov 22
An ion guide includes electrodes elongated along an axis from an entrance end to an exit end and spaced around the axis to surround an interior.
Tong Chen, Gershon Perelman, Curt A. Flory
Filed: 27 Apr 21
Utility
Optimized Coordination and Scheduling of Use of Equipment and Resources Within Work Environment
24 Nov 22
Novel tools and techniques are provided for implementing optimized scheduling of tasks involving equipment used by multiple individuals.
Michael PFLEGER, Theo SCHWEMER
Filed: 30 Nov 20
Utility
Mobile Phase Supply Device with Fluidically Normally Closed Port and Cap Devices
24 Nov 22
A mobile phase supply device, for supplying a mobile phase for a sample separation apparatus for separating a fluidic sample, includes a fluidically normally closed cap device configured to be mounted on a mobile phase container containing a mobile phase, and a fluidically normally closed port device configured for being mechanically connected with the cap device in such a way that, upon establishing a mechanical connection between the port device and the cap device, both the port device and the cap device are converted into a fluidically opened configuration.
Bettina Schuhn, Uwe Effelsberg, Manuel van Venrooy, Matthias Kamuf
Filed: 4 May 22
Utility
Methods and Apparatus for Cell Culture Wellplates
24 Nov 22
The invention relates generally to methods, apparatus and systems for cells in culture.
Jeff Goldman, Jason Dell'Arciprete
Filed: 30 Oct 20
Utility
Sequencing method for genomic rearrangement detection
22 Nov 22
The present disclosure is directed to a single-end sequencing method for improved detection of genomic rearrangements such as deletions, insertions, inversions, and translocations that are present in a polynucleotide.
Margherita Corioni, Douglas N Roberts
Filed: 12 Jul 17
Utility
Mass spectrometry compatible salt formation for ionic liquid sample preparation
22 Nov 22
Reagents and methods for obtaining a metabolite solution comprising a mass spectrometry compatible volatile salt or volatile compound.
Genevieve Van de Bittner
Filed: 1 Mar 19