451 patents
Page 9 of 23
Reissue
Transposase-random priming DNA sample preparation
13 Sep 22
Provided herein, among other things, are a variety of methods for transposase-mediated tagging and amplification of short DNA fragments, e.g., between about 150 bp and 1.5 Kb in length.
Bahram Arezi, Michael Borns, Holly Hogrefe, Connie Hansen
Filed: 8 Nov 19
Utility
Branching Off Fluidic Sample with Low Influence on Source Flow Path
8 Sep 22
A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.
Thomas Ortmann, Daniel Thielsch
Filed: 26 May 22
Utility
Fluid Processing with Withdraw-transfer Modulation
8 Sep 22
A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit.
Dwight Robert Stoll, Konstantin Shoykhet, Thomas Ortmann, Stephan Buckenmaier, Sascha Lege
Filed: 30 Jul 20
Utility
Unions and couplers
6 Sep 22
One aspect of the invention provides a gas chromatography union including: a first port; a second port in fluid communication with the first port; and a first pair of wings defining a first recess.
Allen K. Vickers, Ngoc A Thi Dang, David Jantz
Filed: 28 Feb 20
Utility
Hydrocinnamoyl Protected Riboguanosine Phosphoramidites for Decreasing Depyrimidination from Alkyl Amine Exposure During Final Deprotection
1 Sep 22
Benjamin D. Lunstad, Douglas J. Dellinger, Robert Kaiser
Filed: 26 Feb 22
Utility
Touchless Package
1 Sep 22
A package (100), including a base (150) having at least one receptacle (151), in which the at least one receptacle (151) includes a first portion (154) having a first diameter (D1) and a second portion (152) having a bottom surface and a second diameter (D2) is disclosed.
Olga SCHIKURSKI, Lucas Serge, Qi Siegmundt-Pan, Michael Wherry, Thorsten Dressler, Daniela Loraing, Thomas Dumoulin
Filed: 24 Feb 22
Utility
Optical Imaging Performance Test System and Method
1 Sep 22
For testing the imaging performance of an optical system, a test target is positioned at an object plane of the optical system, and illuminated to generate an image beam.
William K Ridgeway, Alan Dyke, Pengyuan Chen, Rebecca Di Ricco Kurzava
Filed: 7 Aug 20
Utility
Versatile Tube-free Jet for Gas Chromatography Detector
1 Sep 22
A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.
Edward D. MROZ, Heng HE
Filed: 20 May 22
Utility
Nucleic acid enrichment using Cas9
16 Aug 22
A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided.
Brian Jon Peter, Robert A. Ach
Filed: 29 May 14
Utility
Coupled-amplifier multi-frequency circuit topologies applicable to mass spectrometer radio-frequency drive systems
16 Aug 22
A circuit and method for providing high-voltage radio-frequency (RF) energy to an instrument at multiple frequencies includes a plurality of inputs each configured to receive an RF voltage signal oscillating at a corresponding frequency, and a step-up circuit for generating magnified RF voltage signals based on the received RF voltage signals.
Michael J. Schoessow
Filed: 10 Jul 20
Utility
Deep learning based instance segmentation via multiple regression layers
9 Aug 22
Novel tools and techniques are provided for implementing digital microscopy imaging using deep learning-based segmentation and/or implementing instance segmentation based on partial annotations.
Elad Arbel, Itay Remer, Amir Ben-Dor
Filed: 10 Apr 20
Utility
Methods and Kits to Improve the Fluorescent Signal of Dmb-labeled Sialic Acids
4 Aug 22
The present invention provides methods and kits to improve the signal from sialic acids labeled with the dye 1, 2-diamino-4, 5-methylenedioxybenzene (“DMB”).
Francis T. Haxo
Filed: 6 Jun 20
Utility
Vacuum Pumping System Having an Oil-lubricated Vacuum Pump
28 Jul 22
A vacuum pumping system includes an oil-lubricated vacuum pump, including a stationary pump stator and a rotatable pump rotor, and a motor, including a stationary motor stator and a rotatable motor rotor cooperating with each other for driving in rotation the pump rotor.
Roberto Carboneri, Andrea Lepore, Andrea Bertallot, Giovanni Iannucci
Filed: 11 Apr 22
Utility
Mounting a Sample Separation Unit by a Swivel Mechanism
28 Jul 22
A mounting device for mounting a sample separation unit configured for separating, preferably chromatographically separating, compounds in a fluidic sample includes a first fluid connector configured for being mechanically and fluidically coupled with a first fluid interface of the sample separation unit, a second fluid connector configured for being mechanically and fluidically coupled with a second fluid interface of the sample separation unit, and a swivel mechanism configured for swivelling the first fluid connector between a mounting orientation for mounting the first fluid interface of the sample separation unit at the first fluid connector and an alignment orientation for aligning the second fluid interface of the mounted sample separation unit with the second fluid connector for subsequently coupling the second fluid interface with the second fluid connector.
Daniela Loraing, Lena Höninger, Uwe Effelsberg, Andreas Otto, Ansgar Waldbaur, Armin Steinke, Thomas Ortmann, Michael Lang
Filed: 25 Jan 22
Utility
Synthesis of pools of probes by primer extension
19 Jul 22
Provided herein is a method for making a pool of probes by primer extension.
Michael Ruvolo, Emily Marine Leproust
Filed: 5 Mar 13
Utility
Spatial Nucleic Acid Detection Using Oligonucleotide Microarrays
14 Jul 22
The present disclosure is generally directed to detecting nucleic acids.
Robert A. ACH, Nicholas M. SAMPAS, Brian Jon PETER
Filed: 7 Jan 22
Utility
Sequencing an Insert and an Identifier without Denaturation
14 Jul 22
Methods and kits for next-generation sequencing are disclosed.
Kyeong Soo Jeong
Filed: 8 Jan 21
Utility
Double Sided Oil Film Thrust Bearing in a Scroll Pump
14 Jul 22
A vacuum scroll pump having an inlet portion having a pump inlet, and an exhaust portion having a pump outlet; a frame; a stationary scroll plate fixed to the frame and comprising a stationary plate comprising at least one stationary scroll blade; an orbiting scroll plate comprising an orbiting plate comprising at least one orbiting scroll blade projecting axially from a front side of the orbiting plate toward the stationary plate; a drive mechanism supported by the frame and operatively connected to the orbiting scroll plate so as to cause the orbiting scroll plate to orbit about a longitudinal axis of the vacuum scroll pump and thereby pump a process gas; a double-sided thrust bearing supporting the orbiting scroll plate; and a bellows which isolates the process gas from the drive mechanism.
Ronald J. Forni
Filed: 30 Apr 19
Utility
Methods and kits for using blocked 2-AA for glycan analysis
5 Jul 22
The present disclosure provides methods for using anthranilic acid (2-AA) blocked by tertbutyloxycarbonyl (Boc) groups in protocols for labeling glycans for analysis, and kits providing 2-AA-Boc and acids for unblocking blocked 2-AA for use in glycan labeling and analysis.
Sergey Vlasenko, Francis T. Haxo, Andres Guerrero Navarro
Filed: 31 Jan 19
Utility
Chemically Modified Guide Rnas for Crispr/cas-mediated Gene Regulation
23 Jun 22
Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell.
Matthew H. Porteus, Ayal Hendel, Joe Clark, Rasmus O. Bak, Daniel E. Ryan, Douglas J. Dellinger, Robert Kaiser, Joel Myerson
Filed: 14 Mar 22