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GRANT
Utility
Determining the reduced ion mobility of ion species by trapped ion mobility spectrometry (TIMS)
18 Jan 22
The invention provides methods and devices for determining the reduced ion mobility Ko of an ion species by trapped ion mobility spectrometry wherein the reduced ion mobility Ko is determined from a measured arrival time tm of the ion species and predetermined instrumental parameters by applying the inverse of a system function: Ko=SYS−1(tm,pi) or from multiple arrival times tm,i of the ion species measured for multiple values of an instrumental parameter.
Oliver Räther, Karsten Michelmann
Filed: 1 Oct 19
APP
Utility
Peak Width Estimation In Mass Spectra
13 Jan 22
The disclosure relates to a method for processing a mass spectrum, comprising: (i) providing the mass spectrum which contains a plurality of data pairs, each data pair being representative of a mass value or mass-related value on a mass scale or mass-related scale and an abundance value or abundance-related value associated with the respective mass value or mass-related value, (ii) selecting a plurality of intervals on the mass scale or mass-related scale, each interval containing a multitude of the said data pairs, (iii) for each interval, applying a first mathematical-statistical analysis to the said data pairs contained in the respective interval in order to derive an interval-specific peak width, and (iv) using the said interval-specific peak widths to determine an estimated peak width for each mass value or mass-related value on the mass scale or mass-related scale.
Tobias BOSKAMP
Filed: 26 Feb 21
GRANT
Utility
Method for evaluating data from mass spectrometry, mass spectrometry method, and MALDI-TOF mass spectrometer
11 Jan 22
Tobias Boskamp
Filed: 22 Sep 17
APP
Utility
Humidity Stabilization During the Preparation of Biological Samples for Spectrometry
30 Dec 21
The invention proposes preparing biological samples for spectrometry which contain cell structures and/or whole cells of human or animal origin (e.g. thin human and animal tissue sections) or prokaryotes (e.g. microorganisms), and which require constant relative humidity, in a temperature-controlled gas volume whose humidity is determined by a saturated substance solution, for example a suitable salt solution.
Martin SCHÜRENBERG, Sören-Oliver DEININGER, Alice LY
Filed: 4 Jul 18
GRANT
Utility
Mass spectrometric method for determining the presence or absence of a chemical element in an analyte
28 Dec 21
The present invention relates to a mass spectrometric method for determining (predicting) the presence or absence of a chemical element in an analyte which provides valuable information towards reduction of complexity for annotating a chemical formula to the analyte.
Wiebke Andrea Timm, Sebastian Wehner, Nikolas Kessler
Filed: 28 Jan 20
GRANT
Utility
Permanent magnet arrangement for generating a homogeneous field (“3D Halbach”)
7 Dec 21
A magnet arrangement (1) in a magnetic resonance apparatus having a permanent magnet system for generating a homogeneous magnetic field in a direction perpendicular to a z-axis in a measurement volume.
Volker Niemann, Rainer Pietig
Filed: 22 Aug 19
GRANT
Utility
Hybrid mass spectrometric system
7 Dec 21
The invention relates to hybrid IMS/MS systems and provides hybrid IMS/MS system comprising an RF funnel, an ion mobility analyzer and a mass analyzer wherein the RF funnel is arranged non-collinearly to the ion mobility analyzer, preferably a TIMS analyzer (TIMS=trapped ion mobility spectrometry).
Melvin Andrew Park, Mark Ridgeway, Craig Whitehouse, Andreas Brekenfeld
Filed: 22 May 20
GRANT
Utility
MAS probehead with a thermally insulated sample chamber
30 Nov 21
An MAS probehead (1) positioned in a magnet bore (2) includes a sample chamber (3) with a stator (4) for receiving a rotor and an RF coil that radiates RF pulses into and/or receives RF signals from an NMR sample (5).
David Osen, Alexander Krahn, Constantin Schalck
Filed: 14 Feb 20
GRANT
Utility
Hybrid MPI and MRI/CT imaging apparatus and method
9 Nov 21
A hybrid imaging apparatus for imaging an object to be examined located in a sample volume can be operated in an MPI mode and in at least one further imaging mode and comprises a magnet arrangement embodied to generate, in the MPI mode, a magnetic field with a gradient B1 and a field-free region in the sample volume, wherein the magnet arrangement comprises a ring magnet pair with two ring magnets in a Halbach dipole configuration, which are arranged coaxially on a common Z-axis that extends through the sample volume, wherein the ring magnets are arranged so as to be twistable relative to one another about the Z-axis.
Jochen Franke, Volker Niemann
Filed: 19 Oct 20
GRANT
Utility
Method for determining motion states of at least two bodies and method for simultaneously imaging at least two bodies
9 Nov 21
Techniques for determining motion states of at least two bodies by an MR-device are provided, wherein the bodies each have a respective target region which is in an anatomic motion comprising a repetitive motion pattern with a motion repetition rate, and in particular, for cardiac and/or respiratory motion.
Arno Nauerth, Michael Heidenreich
Filed: 23 Oct 18
APP
Utility
Processing of Spatially Resolved, Ion-spectrometric Measurement Signal Data to Determine Molecular Content Scores In Two-dimensional Samples
28 Oct 21
The invention relates to methods for processing ion-spectrometric measurement signal data which are recorded spatially resolved across a two-dimensional sample, comprising: —providing the measurement signal data which have a plurality of measurement signal histograms, where a histogram contains a measurement signal tuple with intensity dimension (J), mass dimension (m), and collision cross-section dimension (σ), or quantities derived therefrom; —specifying first and second selections of ionic species for the sample, whose presence in histograms is detectable and distinguishable using the collision cross-section dimension or proxy; —determining the spatially resolved content of ionic species from the first and second selections in histograms of the finite areas (Afin,x,y), and computing the various contents to form spatially resolved content scores (Gx,y); and —labeling the sample with the content scores (Gx,y).
Tobias BOSKAMP, Dennis TREDE
Filed: 22 Apr 21
GRANT
Utility
Mass spectrometric resistance determination by measuring metabolism
12 Oct 21
The invention relates to a mass spectrometric method to determine microbial resistances to antibiotics.
Markus Kostrzewa, Katrin Sparbier
Filed: 14 Jan 15
GRANT
Utility
Mass spectrometric sample preparation for matrix-assisted ionization
12 Oct 21
The invention relates to the preparation of samples for mass spectrometric analyses with matrix-assisted ionization (e.g.
Waltraud Evers
Filed: 22 Sep 20
APP
Utility
Operation of a Microfluidic Device In the Analysis of Sample Substances
23 Sep 21
The invention relates to methods for operating a microfluidic device in the analysis of sample substances, comprising: (i) providing the microfluidic device, which contains an array of separate sensor spots; (ii) addressing a first selection of the sensor spots with sample substances taken up in fluid, said first selection not comprising the whole array of sensor spots; (iii) optically sensing of the first selection of sensor spots for an interaction with the sample substances; (iv) changing the operation of the microfluidic device in response to the optically sensed interaction, by addressing a second selection of the sensor spots with the sample substances taken up in fluid, said second selection not being identical to the first selection, and (v) analyzing the sample substances by optical sensing of a third selection of sensor spots which is part of the second selection.
Sven MALIK, Paul RITTER, Klaus WIEHLER, Dirk DAMMANN
Filed: 19 Mar 21
APP
Utility
Method for the Spectrometric Characterization of Microorganisms
2 Sep 21
The invention relates to a method for the spectrometric characterization of microorganisms, comprising: providing a test microorganism; acquiring spectrometric measurement data from the test microorganism under potential exposure to variance that is not based on taxonomic classification; selecting a classifier which is trained to determine the identity of a microorganism on a second taxonomic level; and applying the classifier to the measurement data in order to determine the identity of the test microorganism on the second taxonomic level, wherein the classifier is variance-conditioned in such a way that it largely or completely masks out the effect of variance in the characterization of the test microorganism on the second taxonomic level.
Norman MAUDER
Filed: 1 Oct 20
APP
Utility
Method for Generating a Magnetic Resonance Image
2 Sep 21
A method for generating a magnetic resonance image includes providing MR segment data records, wherein each MR segment data record has N×M frequency voxels in k-space.
Michael HERBST
Filed: 24 Feb 21
APP
Utility
System and Method for Detecting Structural Change of a Molecule or Its Environment with NMR Spectroscopy
26 Aug 21
A system, method and computer program product for detecting indicators for structural changes of NMR active test molecules in a test sample, or indicators for structural changes of the environment of said test molecules in relation to a reference molecule.
Christian Fischer, Michael Bernstein, Michael Erich Wilhelm Fey, Ian Michael Clegg
Filed: 29 Jan 21
APP
Utility
Mpi Imaging Device, Method for Generating a Magnetic Field with a Gradient and a Field-free Line by Means of an Mpi Imaging Device
19 Aug 21
An MPI imaging device for mapping an object to be examined in a sample volume, with a magnet arrangement which is designed to generate an MPI magnetic field with a gradient B1 and a field-free line in the sample volume, the magnet arrangement comprising a first pair of magnet rings with two magnet rings in a Halbach dipole configuration, which are arranged coaxially on a common Z axis that runs through the sample volume, wherein the magnet arrangement comprises a second pair of magnet rings with two further magnet rings in a Halbach dipole configuration, which is arranged coaxially in relation to the first pair of magnet rings, the magnet rings of both pairs being arranged rotatably with respect to one another about the Z axis.
Jochen FRANKE, Volker NIEMANN
Filed: 5 Feb 21
GRANT
Utility
Microwave resonator for an EPR probehead providing Q-, M- and D-variation using a variable fluid volume
3 Aug 21
A microwave resonator for an electron paramagnetic resonance probehead comprises a cavity body supporting an electromagnetic microwave resonance mode, at least one sample opening for inserting a sample in a sample container, at least one microwave opening for transmitting microwave radiation into the resonator, and at least one access opening for inserting and removing a modifier in a modifier vessel into or out of the cavity body.
Ion Prisecaru, Peter Höfer
Filed: 20 Jul 20
GRANT
Utility
Maintaining spectral quality over long measuring periods in imaging mass spectrometry
3 Aug 21
The invention relates to imaging mass spectrometry on thin sample sections, in particular using MALDI, where a high lateral image resolution means that a plethora of mass spectra has to be acquired and the image acquisition runs over many hours.
Jens Höhndorf, Andreas Haase
Filed: 5 Feb 20
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