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ILMN Illumina

GRANT
Utility
Catalyst-free surface functionalization and polymer grafting
13 Apr 21
The present application relates to a method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications.
Lorenzo Berti, Andrew A. Brown, Wayne N. George
Filed: 24 May 18
GRANT
Utility
Nucleic acid sequence analysis from single cells
13 Apr 21
Presented herein are methods and compositions for multiplexed single cell gene expression analysis.
Neeraj Salathia, Jian-Bing Fan, Fiona Kaper, Gordon M. Cann, Arash Jamshidi, Alex Aravanis
Filed: 15 Sep 15
GRANT
Utility
System and methods for selective effluent collection
13 Apr 21
A system may include a flow cell through which a plurality of reagents may be pumped during a genetic sequencing operation, an effluent line that, in operation, is to conduct a used reagent, a used reagent valve to receive the used reagent from the effluent line and controllable to select one of a plurality of disposal paths for the used reagent, and control circuitry coupled to the used reagent valve that, in operation, is to control the used reagent valve to select a desired one of the disposal paths depending upon which reagent is being pumped though the flow cell.
Bradley Kent Drews, Kevin James Cappa, Matthew William Hage
Filed: 13 Dec 17
GRANT
Utility
In-line pressure accumulator and flow-control system for biological or chemical assays
13 Apr 21
Flow-control system includes a fluid reservoir configured to store a fluid, a pressure accumulator in flow communication with and positioned downstream from the fluid reservoir, and a loading zone that is configured to receive and fluidly couple to a flow cell having a biological or chemical sample.
Michael J. Stone, Brad Drews, Erik Williamson
Filed: 17 Aug 16
APP
Utility
High-throughput Single-cell Transcriptome Libraries and Methods of Making and of Using
8 Apr 21
Provided herein are methods for preparing a sequencing library that includes nucleic acids from a plurality of single cells.
Frank J. Steemers, Jay Shendure, Junyue Cao
Filed: 4 Jun 19
APP
Utility
Fragment Size Characterization of Cell-free Dna Mutations from Clonal Hematopoiesis
8 Apr 21
Methods and systems are provided for differentiating between cancer variants and somatic variants originating from hematopoietic cells in a cell free DNA sample.
Tingting Jiang
Filed: 16 Sep 20
GRANT
Utility
Methods and compositions using one-sided transposition
6 Apr 21
Embodiments provided herein relate to methods and compositions for next generation sequencing.
Frank J. Steemers, Jeffrey S. Fisher, Kevin L. Gunderson, Sasan Amini, Christian Gloeckner
Filed: 7 Jan 20
GRANT
Utility
Systems and methods for off-target sequence detection
6 Apr 21
A computer-implemented method, computer system and computer-readable medium for identifying off-target matches from a set of candidate primer sequences on a genome reference sequence can include: receiving onto a data storage unit a plurality of candidate primer sequences; for each candidate primer sequence, calculating, using a processor, a plurality of candidate matches on the genome reference sequence for the candidate primer sequences; calculating, using the processor, verified matches on the genome reference sequence based on the candidate matching locations satisfying a plurality of matching verification rules; performing matching calculations of the verified matches to determine whether the verified matches form a match condition on the genome reference sequence; and generating a location profile on the genome reference sequence based on the match condition from the verified matches that meet a predetermined threshold.
Honglei Liu, Jocelyne Bruand
Filed: 14 Sep 17
APP
Utility
Image Sensor Structure
1 Apr 21
An example image sensor structure includes an image layer.
Xiuyu CAI, Ali AGAH, Tracy H. FUNG, Dietrich DEHLINGER
Filed: 11 Dec 20
GRANT
Utility
Compositions and methods for single molecular placement on a substrate
30 Mar 21
Provided herein are methods and compositions for placing single target molecules on a patterned substrate.
Kevin L. Gunderson, Jingwei Bai, Boyan Boyanov
Filed: 6 Jun 19
GRANT
Utility
Hybrid nanopore sensors
30 Mar 21
The disclosure provides detection apparatus having one or more nanopores, methods for making apparatus having one or more nanopore and methods for using apparatus having one or more nanopores.
Boyan Boyanov, Jeffrey G Mandell, Kevin L Gunderson, Jingwei Bai, Liangliang Qiang, Bradley Baas
Filed: 9 Dec 19
APP
Utility
Predicting Sequencer Subsystem Instability in Sequencing Systems
25 Mar 21
The technology disclosed relates to detecting malfunction in a sequencer.
Gregory APKER
Filed: 4 Dec 20
APP
Utility
Flow Cells with Hydrogel Coating
25 Mar 21
In an example of the method, a functionalized coating layer is applied in depressions of a patterned flow cell substrate.
Hongji Ren, Jonathan Mark Boutell, John A. Moon, M. Shane Bowen, Alex Nemiroski, Gary Mark Skinner, Kenny Chen
Filed: 7 Dec 20
APP
Utility
Methods and Compositions for Identifying Ligands on Arrays Using Indexes and Barcodes
25 Mar 21
Some embodiments provided herein include methods and compositions for the detection of target ligands on an array.
Darren Segale, Fiona E. Black, Jeffrey Dennis Brodin, Lorenzo Berti, Siew Hong Leong, Jeffrey S. Fisher, Allen Eckhardt, Rui Zhang, Yin Nah Teo
Filed: 18 Sep 20
APP
Utility
Methods and Compositions for Single Cell Genomics
25 Mar 21
Presented are methods and compositions for obtaining sequence information from one or more individual cells.
Jian-Bing Fan, Kun Zhang
Filed: 28 Sep 20
GRANT
Design
Display screen or portion thereof with graphical user interface icon
23 Mar 21
Eliza Van Gerbig
Filed: 28 Jun 19
GRANT
Utility
Fluid caching
23 Mar 21
An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel.
Wesley A. Cox-Muranami, Darren Robert Segale, Oliver Jon Miller, Jennifer Olivia Foley, Tarun Kumar Khurana, Paul Crivelli, Gary Watts
Filed: 10 Jan 19
GRANT
Utility
Polymer coatings
23 Mar 21
The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells.
Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
Filed: 10 Apr 19
GRANT
Utility
Flow cell package and method for making the same
23 Mar 21
A flow cell package includes first and second surface-modified patterned wafers and a spacer layer.
James Tsay, Anmiv Prabhu, David Heiner, Edwin Li, Alexandre Richez, John M. Beierle, Kevan Samiee, Kristina Munoz, Leonid Malevanchik, Ludovic Vincent, Naiqian Zhan, Peyton Shieh, Robert Yang, Samantha Schmitt, Sang Park, Scott Bailey, Sean M. Ramirez, Sunmin Ahn, Valerie Uzzell, Wei Wei, Yuxiang Huang, Tyler Jamison Dill
Filed: 20 Dec 17
GRANT
Utility
Light detection devices with protective liner and methods related to same
23 Mar 21
Light detection devices and related methods are provided.
Xiuyu Cai, Joseph Francis Pinto, Thomas A. Baker, Tracy Helen Fung
Filed: 11 Dec 18
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