1168 patents
Page 2 of 59
Utility
Deep learning-based pathogenicity classifier for promoter single nucleotide variants (pSNVs)
2 Jan 24
We disclose computational models that alleviate the effects of human ascertainment biases in curated pathogenic non-coding variant databases by generating pathogenicity scores for variants occurring in the promoter regions (referred to herein as promoter single nucleotide variants (pSNVs)).
Sofia Kyriazopoulou Panagiotopoulou, Kai-How Farh
Filed: 20 Sep 19
Utility
Enhancing Clustering Efficiency and Kinetics
28 Dec 23
A co-polymer includes a plurality of a first monomer including a terminal functional group that is to attach to at least two different primers; a plurality of a second monomer including a second functional group that is different from the terminal functional group, and that is selected from the group consisting of a phenyl group, methoxy propyl, glycosyl, vinyl pyrrolidone, and an imidazole group; and a plurality of a third monomer that is different from the first and second monomers.
Gianluca Andrea Artioli, Timothy J.N. Beech, Mathieu Lessard-Viger, Rebecca Turk-MacLeod, Brian D. Mather, Weixian Xi, Xavier von Hatten
Filed: 6 Jun 23
Utility
Light Detection Devices with Protective Liner and Methods Related to Same
28 Dec 23
Light detection devices and related methods are provided.
Xiuyu CAI, Joseph Francis PINTO, Thomas A. BAKER, Tracy Helen FUNG
Filed: 11 Sep 23
Utility
Methods and Compositions for Addressing Inefficiencies In Amplification Reactions
28 Dec 23
Methods and systems for decreasing amplification bias and primer-dimer formation in amplification reactions and for amplifying a plurality of target polynucleotides from a sample in a single reaction and for sequencing the target polynucleotides where samples can include forensic samples and where target polynucleotides can include identity- or ancestry-informative markers, short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs).
Jon-Matthew Belton, Johann Felix Schlesinger, Siarhei Manakou, Amanda Garfinkel Young
Filed: 1 Jun 23
Utility
Variant Calling of High Coverage Samples with a Restricted Memory
28 Dec 23
Systems, methods, and apparatus are described herein for identifying callable regions and performing variant calling while operating within allocated memory.
Adam Michael Birnbaum, Fabian Jobst Klötzl, Arun Visvanath
Filed: 23 Jun 23
Utility
Substrates for Performing Quantification Processes and Related Systems and Methods
28 Dec 23
Substrates for performing quantification processes and related systems and methods are disclosed.
Bryan Crane
Filed: 27 Jun 23
Utility
Fluidic Flow Channel Over Active Surface of a Die
28 Dec 23
Provided herein include various examples of an apparatus, a sensor system and examples of a method for manufacturing aspects of an apparatus, a sensor system.
Arvin Emadi, Arnaud Rival, Ali Agah, Tara Bozorg-Grayeli
Filed: 8 Sep 23
Utility
Accelerators for a Genotype Imputation Model
28 Dec 23
This disclosure describes methods, non-transitory computer readable media, and systems that can determine allele likelihoods of a genomic region exhibiting certain haplotype alleles using one or both of consolidated computations and data exchanges across specialized hardware.
Mark David Hahm, Sven Bilke, Andrew Christopher Du Preez, Michael Ruehle
Filed: 27 Jun 23
Utility
Split-read Alignment by Intelligently Identifying and Scoring Candidate Split Groups
28 Dec 23
The present disclosure relates to systems, non-transitory computer-readable media, and methods for efficiently identifying and selecting split groups corresponding to one or more nucleotide reads.
Michael Ruehle
Filed: 23 Jun 23
Utility
Generating and Implementing a Structural Variation Graph Genome
28 Dec 23
This disclosure describes methods, non-transitory computer readable media, and systems that can generate a structural variation graph genome with alternate contiguous sequences representing structural variant haplotypes.
Fan Zhang, Sean Truong
Filed: 27 Jun 23
Utility
Dependence of Base Calling on Flow Cell Tilt
21 Dec 23
Defocus is introduced during sequencing by synthesis by tilt of a flow cell and by variations in flatness of the flow cell.
Stanley Hong, Michael Gallaspy, Merek Siu, Jeffrey Gau, Anindita Dutta, Aathavan Karunakaran, Simon Prince
Filed: 9 Jun 23
Utility
Functionalization and Purification of Molecules by Reversible Group Exchange
21 Dec 23
Embodiments of the present disclosure include methods and compositions for functionalizing molecules, such as oligonucleotides, with functional groups, including polyhistidine tags useful in affinity methods.
Frank J. Steemers, Kevin L. Gunderson, Kerri York, Ryan Christopher Smith
Filed: 1 Aug 23
Utility
Sequencing Templates Comprising Multiple Inserts and Compositions and Methods for Improving Sequencing Throughput
21 Dec 23
Described herein is a polynucleotide for use as a sequencing template comprising multiple inserts.
Tarun Khurana, Yir-Shyuan Wu, Niall Anthony Gormley, Jonathan Mark Boutell
Filed: 20 Apr 23
Utility
Nanopore Sensing Systems
21 Dec 23
An example of a nanopore sensing system includes an application specific integrated circuit (ASIC) sensor mounted on a printed circuit board having an electrical interface with the ASIC sensor; and a nanopore sequencer formed on the ASIC sensor.
Xu Liu, Lisa Savagian, Arvin Emadi
Filed: 12 Jun 23
Utility
Systems and Methods for Managing Access to a Resource
21 Dec 23
Systems and methods of providing access to a resource via an access management system may include: receiving, at an authorization server, a login request to a user profile from a client application, wherein the login request comprises a set of login credentials; transmitting, from the authorization server to an identity provider, the set of login credentials; authenticating, upon validation of the set of login credentials by the identity provider, the user; receiving, at the authorization server and subsequent to the authenticating, an authentication request from the client application; issuing, subsequent to validating the authentication request and by the authorization server, an access token to the client application; detecting, at a resource server, a request from the client application to access a resource, wherein the request comprises the access token; and enabling, by the resource server and responsive to validating the access token, the client application access to the resource.
Prabhu PALANISAMY, Satnam ALAG, Milan KARANGUTKAR
Filed: 15 Jun 23
Utility
Calibration Sequences for Nucelotide Sequencing
21 Dec 23
This disclosure describes methods, non-transitory computer readable media, and systems that can introduce short calibration sequences into a sequencing device and run calibration cycles to adjust or otherwise determine a sequencing parameter corresponding to the sequencing device.
John S. Vieceli, Bo Lu, Jeffrey S. Fisher
Filed: 24 Feb 23
Utility
System and Method for Secondary Analysis of Nucleotide Sequencing Data
21 Dec 23
Disclosed herein are systems and methods for performing secondary analyses of nucleotide sequencing data in a time-efficient manner.
Francisco Jose GARCIA, Come RACZY, Aaron DAY, Michael J. CARNEY
Filed: 13 Apr 23
Utility
Flow cell package and method for making the same
19 Dec 23
A flow cell package includes first and second surface-modified patterned wafers and a spacer layer.
James Tsay, Anmiv Prabhu, David Heiner, Edwin Li, Alexandre Richez, John M. Beierle, Kevan Samiee, Kristina Munoz, Leonid Malevanchik, Ludovic Vincent, Naiqian Zhan, Peyton Shieh, Robert Yang, Samantha Schmitt, Sang Park, Scott Bailey, Sean M. Ramirez, Sunmin Ahn, Valerie Uzzell, Wei Wei, Yuxiang Huang, Tyler Jamison Dill
Filed: 3 Mar 21
Utility
Ultrathin Membranes for Nanoscale Pores and Channels
14 Dec 23
A nanopore sensing system includes a cis well, a trans well, and a metal based membrane positioned between the cis and trans wells so that a channel defined in the metal based membrane fluidically connects the cis and trans wells.
Rajesh Kumar Sharma, Gerald Kreindl, Anthony Flannery
Filed: 9 Jun 23
Utility
Flow cells and sequencing kits
12 Dec 23
In one example, a flow cell includes a substrate, an electrode positioned on the substrate, and a patterned material positioned on the electrode.
Hayden Black, Brian D. Mather
Filed: 3 Dec 19