1168 patents
Page 4 of 59
Utility
Methods and Compositions for Analyzing Cellular Components
23 Nov 23
Embodiments of the present invention relate to analyzing components of a cell.
Kevin L. Gunderson, Frank J. Steemers, Jeffrey S. Fisher, Roberto Rigatti
Filed: 27 Feb 23
Utility
Flow cells with a hydrophobic barrier
21 Nov 23
An example of a flow cell includes a substrate, which includes nano-depressions defined in a surface of the substrate, and interstitial regions separating the nano-depressions.
Tarun Kumar Khurana, Arnaud Rival, Lewis J. Kraft, Steven Barnard, M. Shane Bowen, Xi-Jun Chen, Yir-Shyuan Wu, Jeffrey S. Fisher, Dajun Yuan
Filed: 26 Apr 22
Utility
Actuation systems and methods
21 Nov 23
Actuation systems and methods are disclosed.
Reto Schoch, Xuance Zhou, Tarun Khurana, Chetanya Jain, Gregory Suematsu
Filed: 22 Dec 22
Utility
Adaptive Neural Network for Nucelotide Sequencing
16 Nov 23
This disclosure describes methods, non-transitory computer readable media, and systems that can configure a field programmable gate array (FPGA) or other configurable processor to implement a neural network and train the neural network using the configurable processor by modifying certain network parameters of a subset of the neural network’s layers.
Gavin Derek Parnaby
Filed: 10 May 23
Utility
Universal short adapters for indexing of polynucleotide samples
14 Nov 23
The disclosed embodiments concern index oligonucleotides configured to identify sources of samples of nucleic acids and methods, apparatus, systems and computer program products for identifying and making the index oligonucleotides.
Tatjana Singer, Ryan Kelley, Gordon Bean, Eric Vermaas
Filed: 4 May 21
Utility
Autofocus functionality in optical sample analysis
14 Nov 23
A method comprises: directing, using an objective and a first reflective surface, first autofocus light toward a sensor, the first autofocus light reflected from a first surface of a substrate; preventing second autofocus light from reaching the sensor, the second autofocus light reflected from a second surface of the substrate; and directing, using the objective and a second reflective surface, emission light toward the sensor, the emission light originating from a sample at the substrate.
Simon Prince, Danilo Condello, Vincent Hsieh, Krysada Phounsiri, John O'Shaughnessy
Filed: 22 Dec 20
Utility
Optical distortion correction for imaged samples
14 Nov 23
Techniques are described for dynamically correcting image distortion during imaging of a patterned sample having repeating spots.
Robert Langlois, Paul Belitz
Filed: 23 Dec 22
Utility
Base calling using three-dimentional (3D) convolution
14 Nov 23
We propose a neural network-implemented method for base calling analytes.
Emrah Kostem
Filed: 19 Oct 22
Utility
Polymerases, Compositions, and Methods of Use
9 Nov 23
Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
Kay Klausing, Hamed Tabatabaei Ghomi, Misha Golynskiy, Saurabh Nirantar, Seth McDonald, Sergio Peisajovich
Filed: 13 Mar 23
Utility
Reagent Cartridges and Related Systems and Methods for Controlling Reagent Temperature
9 Nov 23
Reagent cartridges and related systems and methods for controlling reagent temperature are disclosed.
Elisabet Rosas, Philip Balding, Cyril Delattre, Jacqueline Weir, Ramir Vega, Jennifer Foley, Paul Sangiorgio, Darren Segale, Pietro Gatti Lafranconi, Tarun Khurana, Jacob Ruden, Craig Hetherington
Filed: 2 Mar 22
Utility
Systems and Methods for Analysis of Samples
9 Nov 23
Systems and methods for determining an amount of a predefined category are provided.
Kate Broadbent, Robert Schlaberg
Filed: 4 Feb 22
Utility
Cleavable Cyclic Loop Nucleotides for Nanopore Sequencing
9 Nov 23
In one aspect, the disclosed technology relates to nanopore sequencing with a polynucleotide comprising a plurality of nucleotides, wherein each nucleotide comprises a linker construct between two positions of the nucleotide, wherein the linker construct optionally comprises a reporter moiety corresponding to the identity of the nucleotide, and wherein the linker construct is a part of the cleavable cyclic loop nucleotide comprising a cleavable site.
Abdul Sadeer Abd Salam, Xiangyuan Yang, Hassan Zakiruddin Bohra, Yin Nah Teo, Min Yen Lee, Ramesh Neelakandan, Jeffrey G. Mandell, Erin Garcia, Sharyuen Soh, Daniel Hartoyo Lukamto
Filed: 3 May 23
Utility
Polymer Coatings
9 Nov 23
The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells.
Wayne N. George, Andrew A. Brown, Daniel Bratton, Hongji Ren, Ryan Christopher Smith
Filed: 26 May 23
Utility
Compositions and Methods for Improving Sequencing Signals
9 Nov 23
Embodiments of the present disclosure relate to compositions and kits for use in sequencing by synthesis to improve fluorescent signal intensity and reduce signal decay caused by short wavelength light source during the imaging events.
Huihong YOU, Samuel CABER, Michael CHESNEY, Jie MAO, Alexandre RICHEZ, Rebecca MACLEOD, Emily WELCH, Zhong MEI, Xiaolin WU, Carole ANASTASI, Alexander FUHRMANN
Filed: 29 Mar 23
Utility
Biosensors for Biological or Chemical Analysis and Methods of Manufacturing the Same
9 Nov 23
Biosensor including a device base having a sensor array of light sensors and a guide array of light guides.
Cheng Frank Zhong, Hod Finkeslstien, Boyan Boyanov, Dietrich Dehlinger, Darren Segale
Filed: 21 Jun 23
Utility
Calcium carbonate slurry
7 Nov 23
A composition is provided that comprises a calcium carbonate slurry.
Robert Yang, Samantha K. Brittelle, You-Jung Cheng, Scott William Bailey, James M. Tsay
Filed: 6 Dec 21
Utility
Systems and Methods for Analysis of Presence of Microorganisms
2 Nov 23
A method for reviewing sequencing data for identifying microorganisms in a sample is provided.
Robert Schlaberg, Steven Flygare, Kate Broadbent, Qing Li, Hajime Matsuzaki, Wan Xie
Filed: 23 Feb 22
Utility
Identifying Nucleotides by Determining Phasing
2 Nov 23
Methods and systems for analysis of image data generated from various reference points.
Francisco Jose Garcia, Klaus Maisinger, Stephen Tanner, John A. Moon, Tobias Mann, Michael Lawrence Parkinson, Anthony James Cox, Haifang H. Ge
Filed: 19 Apr 23
Design
Flow cell device
31 Oct 23
Jay Taylor, Bradley Drews, James Osmus, Philip Paik, Tsukasa Takahashi, Brandon Westerberg, Jack Godfrey Wood, Carlos Dominguez
Filed: 27 Jul 22
Utility
Flexible seed extension for hash table genomic mapping
31 Oct 23
Methods, systems, and apparatuses, including computer programs for generating and using a hash table configured to improve mapping of reads are disclosed that include obtaining a first seed of K nucleotides from a reference sequence, generating a seed extension tree having a nodes, wherein each node of the nodes corresponds to (i) an extended seed that is an extension of the first seed and has a nucleotide length of K* and (ii) one or more locations, in a seed extension table, that include data describing reference sequence locations that match the extended seed, and for each node: storing interval information at a location of the hash table that corresponds to an index key for the extended seed, wherein the interval information references one or more locations in the seed extension table that include reference sequence locations that match the extended seed associated with the node.
Michael Ruehle
Filed: 22 May 20