1168 patents
Page 8 of 59
Utility
Methods and systems for generation and error-correction of unique molecular index sets with heterogeneous molecular lengths
19 Sep 23
The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length.
Kevin Wu, Chen Zhao, Han-Yu Chuang, Alex So, Stephen Tanner, Stephen M. Gross
Filed: 16 Oct 20
Utility
Beads as Transposome Carriers
14 Sep 23
Degradable polyester bead are described comprising a plurality of transposome complexes immobilized to the surface thereof, wherein each transposome complex comprises a transposase bound to a first polynucleotide and a second polynucleotide, wherein the first polynucleotide comprises a 3′ portion comprising a transposon end sequence and a tag, and the second polynucleotide comprises a 5′ portion that is complementary to and hybridized to the transposon end sequence, and wherein the polyester bead has a melting point of from 50° C. to 65° C.
Yir-Shyuan Wu, Tarun Kumar Khurana, Elisabet Rosàs-Canyelles, Fei Shen, Jeffrey Brodin, Lena Storms, Jeffrey S. Fisher
Filed: 6 Jan 23
Utility
Methods and Compositions for Recombinase-mediated Selective Cleavage of Nucleic Acids
14 Sep 23
Embodiments of the methods and compositions provided herein relate to the selective cleavage of target nucleic acids.
Clifford Lee Wang
Filed: 11 Apr 23
Utility
Multi-pass Software-accelerated Genomic Read Mapping Engine
14 Sep 23
Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for software-accelerated genomic data read mapping.
Guillaume Alexandre Pascal Rizk
Filed: 3 Mar 23
Utility
Flow Cell Surface Patterning
14 Sep 23
In an example method, a polymeric hydrogel is applied to a surface of a substrate including depressions separated by interstitial regions.
Tanmay Ghonge, Brian D. Mather
Filed: 22 Dec 22
Utility
Systems and Related Sample Loading Manifold Assemblies
14 Sep 23
An apparatus includes one or more valves adapted to be coupled to corresponding reagent reservoirs and a flow cell interface adapted to be coupled to a flow cell.
Bradley Drews, Reto Schoch, Tarun Kumar Khurana, Minsoung Rhee
Filed: 23 May 23
Utility
System and Method for Storage
14 Sep 23
Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells.
Merek Siu, Ali Agah, Stanley Hong, Tarun Khurana, Aathavan Karunakaran, Craig Ciesla, Amirali Kia
Filed: 31 Jan 23
Design
Cartridge label
12 Sep 23
Christopher Morgan Dye, Gi Youn Lee, Max Warren Pollock, Vincent Russell Derama, Nahida Lebbos, Raymond Lawrence Oyung, Madeline Uebelhor, Jack Godfrey Wood, John Tate Sager, Jacob Dessau
Filed: 13 May 22
Design
Cartridge label
12 Sep 23
Christopher Morgan Dye, Gi Youn Lee, Max Warren Pollock, Vincent Russell Derama, Nahida Lebbos, Raymond Lawrence Oyung, Madeline Uebelhor, Jack Godfrey Wood, John Tate Sager, Jacob Dessau
Filed: 13 May 22
Utility
Circulating RNA signatures specific to preeclampsia
12 Sep 23
The present invention includes methods and materials for use in the detection preeclampsia and/or determining an increased risk for preeclampsia in a pregnant female, the method including identifying in a biosample obtained from the pregnant women a plurality of circulating RNA (C-RNA) molecules.
Sarah E. Shultzaberger, Fiona Kaper, Sarah Kinnings, Suzanne Rohrback, Carlo Randise-Hinchliff
Filed: 20 Nov 20
Utility
Sequence-Specific Targeted Transposition and Selection and Sorting of Nucleic Acids
7 Sep 23
A variety of different types of targeted transposome complexes are described herein that may be used to mediate sequence-specific targeted transposition of nucleic acids.
Frank J. STEEMERS, Jonathan Mark BOUTELL, Pietro GATTI LAFRANCONI, Oliver Jon MILLER, Emma BELL, Sebastien Georg Gabriel RICOULT, Niall Anthony GORMLEY, Kim SCHNEIDER
Filed: 16 Feb 23
Utility
Flow Cells and Methods
7 Sep 23
An example of a flow cell includes a substrate having depressions separated by interstitial regions.
Johan Sebastian Basuki, Jonathan Mark Boutell, Jeffrey S. Fisher, Louise Jane Fraser, Wayne N. George, Niall Anthony Gormley, David Jones, Xiaoyu Ma, Maria Ines Martins Vitoriano, Zhong Mei, Oliver Jon Miller, Andrew Price, Sebastien Georg Gabriel Ricoult, Vicki S. Thomson, Jacqueline C. Weir, Xiaoy Ma, Weihua Chang, Hui Han
Filed: 23 Dec 22
Utility
Non-contact Dispensers and Related Methods
7 Sep 23
Non-contact dispensers and related methods are disclosed.
Xuance Zhou, Reto Schoch
Filed: 3 Mar 23
Utility
Systems and Methods for Grouping and Collapsing Sequencing Reads
7 Sep 23
Disclosed herein are systems and methods for collapsing sequencing reads and identifying similar sequencing reads.
Chen Zhao, Kevin Eric Wu, Sven Bilke
Filed: 12 May 23
Utility
Flow cells and methods related to same
5 Sep 23
Flow cells and corresponding methods are provided.
Arnaud Rival, Ali Agah, Tracy H. Fung, Dietrich Dehlinger, Poorya Sabounchi, Tarun Khurana, Craig M. Ciesla, M. Shane Bowen
Filed: 11 Jul 22
Utility
Artificial intelligence-based many-to-many base calling
5 Sep 23
The technology disclosed relates to artificial intelligence-based base calling.
Anindita Dutta, Gery Vessere, Dorna Kashefhaghighi, Kishore Jaganathan, Amirali Kia
Filed: 19 Feb 21
Utility
Enrichment of Mutated Cell Free Nucleic Acids for Cancer Detection
31 Aug 23
Provided herein are methods of enriching mutated cell free nucleic acids for detection and diagnosis of cancer.
Gordon Cann, Alex Aravanis, Arash Jamshidi, Rick Klausner, Richard Rava
Filed: 10 Apr 23
Utility
Methods and Compositions for Preparing Nucleic Acid Libraries
31 Aug 23
Embodiments provided herein relate to methods and compositions for preparing nucleic acid libraries.
Raquel Maria Sanches-Kuiper, Vincent Peter Smith, Sean Humphray
Filed: 1 Nov 22
Utility
Compositions, Systems, and Methods for Detecting the Presence of Polymer Subunits Using Chemiluminescence
31 Aug 23
Under one aspect, a composition includes a substrate; a first polynucleotide coupled to the substrate; a second polynucleotide hybridized to the first polynucleotide; and a catalyst coupled to a first nucleotide of the second polynucleotide, the catalyst being operable to cause a chemiluminogenic molecule to emit a photon.
Boyan Boyanov, Liangliang Qiang, Kevin L. Gunderson, Kay Klausing, Lea Pickering, Cyril Delattre, Tarun Khurana
Filed: 6 Mar 23
Utility
Protective Surface Coatings for Flow Cells
31 Aug 23
An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer.
Sean M. Ramirez, Brian D. Mather, Edwin Li, Sojeong Moon, Innsu Daniel Kim, Alexandre Richez, Ludovic Vincent, Xavier von Hatten, Hai Quang Tran, Maxwell Zimmerley, Julia Morrison, Gianluca Andrea Artioli, Krystal Sly, Hayden Black, Lewis J. Kraft, Hong Xie, Wei Wei, Ryan Sanford
Filed: 9 May 23