394 patents
Utility
Biosensors for biological or chemical analysis and systems and methods for same
16 Jan 24
A biosensor is provided including a detection device and a flow cell mounted to the detection device.
Helmy A. Eltoukhy, Robert C. Kain, Wenyi Feng, Mark Pratt, Bernard Hirschbein, Poorya Sabounchi, Tarun Khurana
Filed: 7 Mar 23
Utility
Federated systems and methods for medical data sharing
16 Jan 24
Systems, computer-implemented methods, and non-transitory computer readable media are provided for sharing medical data.
Kai-How Farh, Donavan Cheng, John Casey Shon, Jorg Hakenberg, Eugene Bolotin, James Geaney, Hong Gao, Pam Cheng, Inderjit Singh, Daniel Roche, Milan Karangutkar
Filed: 7 Feb 22
Utility
Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS)
9 Jan 24
The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index (UMI) sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length.
Sante Gnerre, Byoungsok Jung, Emrah Kostem, Alex Aravanis, Alex So, Xuyu Cai, Zhihong Zhang, Frank J. Steemers
Filed: 21 Oct 20
Utility
Flow cell with one or more barrier features
9 Jan 24
An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features.
Tarun Khurana, Ali Agah, Aathavan Karunakaran, Stanley Hong, Merek Siu, Arvin Emadi, Craig Ciesla
Filed: 9 Feb 23
Utility
Systems and methods for determining whether a subject has a cancer condition using transfer learning
9 Jan 24
Systems and methods for classifier training are provided.
M. Cyrus Maher
Filed: 22 May 20
Utility
Deep learning-based pathogenicity classifier for promoter single nucleotide variants (pSNVs)
2 Jan 24
We disclose computational models that alleviate the effects of human ascertainment biases in curated pathogenic non-coding variant databases by generating pathogenicity scores for variants occurring in the promoter regions (referred to herein as promoter single nucleotide variants (pSNVs)).
Sofia Kyriazopoulou Panagiotopoulou, Kai-How Farh
Filed: 20 Sep 19
Utility
Flow cell package and method for making the same
19 Dec 23
A flow cell package includes first and second surface-modified patterned wafers and a spacer layer.
James Tsay, Anmiv Prabhu, David Heiner, Edwin Li, Alexandre Richez, John M. Beierle, Kevan Samiee, Kristina Munoz, Leonid Malevanchik, Ludovic Vincent, Naiqian Zhan, Peyton Shieh, Robert Yang, Samantha Schmitt, Sang Park, Scott Bailey, Sean M. Ramirez, Sunmin Ahn, Valerie Uzzell, Wei Wei, Yuxiang Huang, Tyler Jamison Dill
Filed: 3 Mar 21
Utility
Flow cells and sequencing kits
12 Dec 23
In one example, a flow cell includes a substrate, an electrode positioned on the substrate, and a patterned material positioned on the electrode.
Hayden Black, Brian D. Mather
Filed: 3 Dec 19
Utility
Method and system for fluorescence lifetime based sequencing
12 Dec 23
An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods.
Hod Finkelstein, Cheng Frank Zhong, Eliane H. Trepagnier
Filed: 28 Dec 20
Utility
Automated volumetric reagent delivery testing
12 Dec 23
A system includes a reagent selector valve controllable to select a reagent flow path from a plurality of reagent flow paths, and a pump coupled to the reagent flow path to draw a liquid through the reagent flow path in accordance with a prescribed test protocol.
Bradley Kent Drews, Kevin James Cappa
Filed: 23 Mar 21
Utility
Deep learning-based aberrant splicing detection
5 Dec 23
The technology disclosed relates to constructing a convolutional neural network-based classifier for variant classification.
Kishore Jaganathan, Kai-How Farh, Sofia Kyriazopoulou Panagiotopoulou, Jeremy Francis McRae
Filed: 15 Oct 18
Utility
Microarray fabrication system and method
5 Dec 23
A method includes forming a patterned substrate including a plurality of base pads, using a nano-imprint lithography process.
M. Shane Bowen, Kevin L. Gunderson, Shengrong Lin, Maria Candelaria Rogert Bacigalupo, Kandaswamy Vijayan, Yir-Shyuan Wu, Bala Murali Venkatesan, James Tsay, John M. Beierle, Lorenzo Berti, Sang Ryul Park
Filed: 7 Dec 20
Utility
System and method with fiducials having offset layouts
5 Dec 23
Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing.
John S. Vieceli, Alex Nemiroski, Paul Belitz, Robert Langlois, M. Shane Bowen, Danny Yuan Chan, Bala Murali K. Venkatesan, Hui Han, Kevan Samiee, Stephen Tanner
Filed: 31 Jan 18
Utility
Obtaining information from a biological sample in a flow cell
5 Dec 23
Methods are used for obtaining, cataloguing, and/or storing data derived from a biological source using a flow cell body, electrodes, and an imaging assembly.
Tarun Khurana, Ali Agah, Aathavan Karunakaran, Xi-Jun Chen
Filed: 9 Sep 21
Utility
Methods and compositions for nucleic acid sequencing
28 Nov 23
The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample.
Robert C. Kain, Xiaohai Liu, Wenyi Feng, Bernard Hirschbein, Helmy A. Eltoukhy, Xiaolin Wu, Geoffrey Paul Smith, Jonathan Mark Boutell, Thomas Joseph, Randall Smith, Min-Jui Richard Shen, Carolyn Tregidgo, Kay Klausing
Filed: 20 Jan 21
Utility
Systems and methods for structured illumination microscopy
28 Nov 23
The technology disclosed relates to structured illumination microscopy (SIM).
Bo Lu, Robert Ezra Langlois, Andrew James Young, Andrew Dodge Heiberg
Filed: 21 Nov 22
Utility
Flow cells with a hydrophobic barrier
21 Nov 23
An example of a flow cell includes a substrate, which includes nano-depressions defined in a surface of the substrate, and interstitial regions separating the nano-depressions.
Tarun Kumar Khurana, Arnaud Rival, Lewis J. Kraft, Steven Barnard, M. Shane Bowen, Xi-Jun Chen, Yir-Shyuan Wu, Jeffrey S. Fisher, Dajun Yuan
Filed: 26 Apr 22
Utility
Actuation systems and methods
21 Nov 23
Actuation systems and methods are disclosed.
Reto Schoch, Xuance Zhou, Tarun Khurana, Chetanya Jain, Gregory Suematsu
Filed: 22 Dec 22
Utility
Universal short adapters for indexing of polynucleotide samples
14 Nov 23
The disclosed embodiments concern index oligonucleotides configured to identify sources of samples of nucleic acids and methods, apparatus, systems and computer program products for identifying and making the index oligonucleotides.
Tatjana Singer, Ryan Kelley, Gordon Bean, Eric Vermaas
Filed: 4 May 21
Utility
Autofocus functionality in optical sample analysis
14 Nov 23
A method comprises: directing, using an objective and a first reflective surface, first autofocus light toward a sensor, the first autofocus light reflected from a first surface of a substrate; preventing second autofocus light from reaching the sensor, the second autofocus light reflected from a second surface of the substrate; and directing, using the objective and a second reflective surface, emission light toward the sensor, the emission light originating from a sample at the substrate.
Simon Prince, Danilo Condello, Vincent Hsieh, Krysada Phounsiri, John O'Shaughnessy
Filed: 22 Dec 20