47 patents
Utility
Detecting gastric neoplasm
2 Jan 24
Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.
David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney, Hatim T. Allawi
Filed: 5 Feb 20
Utility
Fecal sample processing and analysis comprising detection of blood
19 Dec 23
A method of processing a fecal sample from a human subject comprising removing a portion of a collected fecal sample and adding the removed portion of the sample to a buffer that prevents denaturation or degradation of blood proteins found in the sample, and detecting the presence of human blood in the removed portion of the fecal sample.
Joost Louwagie
Filed: 27 Jun 17
Utility
Mutation detection assay
19 Dec 23
A method of sample analysis is provided.
Hongzhi Zou, Graham P. Lidgard, Michael J. Domanico, Hatim Allawi
Filed: 8 Jul 21
Utility
Detecting neoplasm
21 Nov 23
Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as pancreatic and colorectal cancer.
David A. Ahlquist, John B. Kisiel, William R. Taylor, Tracy C. Yab, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
Filed: 12 May 20
Utility
Modification of DNA on magnetic beads
14 Nov 23
Provided herein is technology related to the chemical modification and purification of DNA.
Michael J. Domanico, Hatim Allawi, Graham P. Lidgard, Brian Aizenstein, Oliver Hunt, Tobias Charles Zutz
Filed: 29 May 20
Utility
Ergonomic stool specimen container and enclosing holder systems, methods, and kits
31 Oct 23
Provided herein is technology relating to collecting and containing samples and particularly, but not exclusively, to technology for collecting and containing a stool specimen.
Joseph E. Schiestle, Krystal A. Burger, Timothy A. Parmer, Jad A. Lunde, Sam M. Jang, David A. Schuelke, David B. Wolgemuth, Jing Yang Lu
Filed: 6 Nov 20
Utility
Compositions comprising ZDHHC1 DNA in a complex
5 Sep 23
Provided herein is technology relating compositions and methods for detecting tissue cell-specific DNA, such as epithelial cell-specific DNA, in blood or blood products from a subject.
Hatim T. Allawi, Graham P. Lidgard
Filed: 28 Oct 19
Utility
Normalization of polymerase activity
25 Jul 23
Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
Filed: 11 Feb 21
Utility
Method for stabilizing hemoglobin and reagents for performing the same
18 Jul 23
A stool resuspension solution comprising a hemoglobin stabilization reagent is provided.
Keith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
Filed: 6 Jun 22
Utility
Detecting ovarian cancer
18 Jul 23
Provided herein is technology for ovarian cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of ovarian cancer and sub-types of ovarian cancer (e.g., clear cell ovarian cancer, endometrioid ovarian cancer, mucinous ovarian cancer, serous ovarian cancer).
William R. Taylor, John B. Kisiel, Douglas W. Mahoney, David A. Ahlquist, Hatim T. Allawi, Michael W. Kaiser
Filed: 30 Oct 20
Utility
Detecting prostate cancer
11 Jul 23
Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.
David A. Ahlquist, William R. Taylor, John B. Kisiel, Tracy C. Yab, Douglas W. Mahoney, Brian A. Dukek, Matthew T. Gettman, Hatim T. Allawi
Filed: 8 Jan 21
Utility
Methylation assay
27 Jun 23
A method for detecting a methylated genomic locus is provided.
Graham P. Lidgard, Michael J. Domanico, Hatim Allawi, Hongzhi Zou
Filed: 8 Feb 21
Utility
Fecal sample processing and analysis comprising detection of blood
25 Apr 23
A method of processing a fecal sample from a human subject comprising removing a portion of a collected fecal sample and adding the removed portion of the sample to a buffer that prevents denaturation or degradation of blood proteins found in the sample, and detecting the presence of human blood in the removed portion of the fecal sample.
Joost Louwagie
Filed: 28 Sep 22
Utility
Detection of lung neoplasia by amplification of RNA sequences
25 Oct 22
Provided herein is technology for lung neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of lung cancer.
Hatim Allawi, Graham P. Lidgard, Chateen Krueger, Michael W. Kaiser, Tamara J. Sander
Filed: 23 Oct 20
Utility
Method for stabilizing hemoglobin and reagents for performing the same
12 Jul 22
A stool resuspension solution comprising a hemoglobin stabilization reagent is provided.
Keith D. Fourrier, Jacquelyn T. Hennek, Michael J. Domanico, William G. Weisburg, Graham P. Lidgard, Kathleen S. Harings, Daniel J. Simpson
Filed: 15 Mar 19
Utility
Detecting colorectal neoplasm
21 Jun 22
Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
David A. Ahlquist, William R. Taylor, Douglas W. Mahoney, Graham P. Lidgard, Hatim T. Allawi
Filed: 30 Apr 19
Utility
Methylated control DNA
31 May 22
Provided herein is technology relating compositions and methods for analysis of methylated DNA from a subject.
Hatim T. Allawi, Graham P. Lidgard
Filed: 19 Jul 17
Utility
Nucleic acid control molecules from non-human organisms
28 Dec 21
The present invention provides synthetic DNA strands that find use as process controls in DNA processing and nucleic acid testing methods.
Hatim T. Allawi, Graham P. Lidgard, Brian Aizenstein, Melissa M. Gray
Filed: 19 Jul 17
Utility
Multiplex amplification detection assay II
7 Dec 21
Provided herein is technology relating to the amplification-based detection of bisulfite-treated DNAs and particularly, but not exclusively, to methods and compositions for multiplex amplification of low-level sample DNA prior to further characterization of the sample DNA.
Hatim T. Allawi, William G. Weisburg, Graham P. Lidgard, Michael W. Kaiser, Abram M. Vaccaro, Gracie Shea
Filed: 12 Feb 20
Utility
Methods for detecting epigenetic modifications
19 Oct 21
A method of detecting a predisposition to, or the incidence of, cancer in a sample comprises detecting an epigenetic change in at least one gene selected from an NDRG4/NDRG2 subfamily gene, GATA4, OSMR, GATA5, SFRP1, ADAM23, JPH3, SFRP2, APC, MGMT, TFPI2, BNIP3, FOXE1, SYNE1, SOX17, PHACTR3 and JAM3, wherein detection of the epigenetic change is indicative of a predisposition to, or the incidence of, cancer.
Manon Van Engeland, Manon Adriaan De Bruine, Arjan Griffioen, Joost Louwagie, Katja Bierau, Gontran Brichard, Gaetan Otto, Maarten Penning
Filed: 8 Oct 18