Engineered Cells for Improved Production of Cannabinoids
28 Apr 22
The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing synthesis of olivetolic acid, olivetolic acid derivatives and/or cannabinoids.
Michael A. Noble, Jonathan Moore, Jingyi Li, Anna Lechner
Filed: 30 Jan 20
Microorganisms for the production of adipic acid and other compounds
5 Apr 22
The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway.
Anthony P. Burgard, Priti Pharkya, Robin E. Osterhout
Filed: 23 Aug 19
1,3-Fatty Diol Compounds And Derivatives Thereof
31 Mar 22
The disclosure relates to the field of specialty chemicals.
Filed: 5 Oct 21
Recovery, Decarboxylation, and Purification of Cannabinoids from Engineered Cell Cultures
31 Mar 22
Methods of recovering cannabinoids from cell cultures include methods comprising steps of separating the cell culture at a temperature above the melting point of the cannabinoid to separate a light phase comprising liquid state cannabinoid from a heavy phase; and methods comprising treating the cell culture at a temperature below the melting point of the cannabinoid to separate a light phase from a heavy phase comprising solid state cannabinoid.
Lauri H. Suominen, Jefferson Lievense, Aiguo Liu, Jorge Jesus Martinez-Gonzalez, Myong Kon Ko, Wei Nan
Filed: 30 Jan 20
Process for the Production of Epsilon Caprolactam from 6- Aminocaproic Acid
24 Mar 22
A new process for the production of epsilon caprolactam (CPL) from 6-aminocaproic acid (6-ACA) can be obtained either from traditional petro chemical processes or can be obtained from biochemical processes.
Michele CECCHETTO, Anacleto DAL MORO, Lauri Hannunpoika SUOMINEN, Michael JAPS
Filed: 23 Dec 19
ACYL-ACP Reductase With Improved Properties
24 Mar 22
The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells.
Mathew RUDE, Na TRINH, Andreas SCHIRMER, Jacob GANO
Filed: 18 Aug 21
Preparation of 6-AMINOCAPROIC Acid from 5-FORMYL Valeric Acid
3 Mar 22
The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst.
Petronella Catharina Raemakers-Franken, Martin Schurmann, Axel Christoph Trefzer, Stefaan Marie Andre De Wildeman
Filed: 14 Apr 21
Enzymatic Biosynthesis Of Lactones
3 Mar 22
The disclosure relates to methods for the production of natural lactones by bacteria under physiological conditions.
Andreas W. SCHIRMER, Katherine Ann MURPHY, Angelica Zabala BAUTISTA
Filed: 15 Jan 20
Microorganisms and Methods for the Biosynthesis of Aromatics, 2,4-PENTADIENOATE and 1,3-BUTADIENE
24 Feb 22
The invention provides non-naturally occurring microbial organisms having a toluene, benzene, p-toluate, terephthalate, (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate, (2-hydroxy-4-oxobutoxy)phosphonate, benzoate, styrene, 2,4-pentadienoate, 3-butene-1ol or 1,3-butadiene pathway.
Robin E. Osterhout, Anthony P. Burgard, Priti Pharkya, Mark J. Burk
Filed: 7 Apr 21
Microorganisms and Methods for the Biosynthesis of Butadiene
27 Jan 22
The invention provides non-naturally occurring microbial organisms having a butadiene pathway.
Mark J. Burk, Anthony P. Burgard, Jun Sun, Robin E. Osterhout, Priti Pharkya
Filed: 5 Mar 21
XYLR Mutant For Improved Xylose Utilization Or Improved Co-Utilization Of Glucose And Xylose
6 Jan 22
The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism.
Stephen Thomas PAYNE, Scott Allen FRYKMAN, Bernardo Moura Torres DA COSTA, Isolde CALLIHAN, Sankaranarayanan VENKITESWARAN, Leland Ken WONG
Filed: 29 Aug 19
Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
28 Dec 21
The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway.
Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya
Filed: 7 Dec 18
Methods And Compositions Related To Thioesterase Enzymes
2 Dec 21
The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes.
Louis HOM, Na TRINH, Murtaza ALIBHAI, Zhihao HU, Eli GROBAN, Vikranth ARLAGADDA, Elizabeth CLARKE
Filed: 17 Mar 21
Methods And Compositions For Improved Production Of Fatty Acids And Derivatives Thereof
2 Dec 21
The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
Derek L. GREENFIELD, Louis G. HOM, Fernando A. SANCHEZ-RIERA, Zhihao HU, Vikranth ARLAGADDA, Eli S. GROBAN, Scott A. FRYKMAN
Filed: 17 Jun 21
Microorganisms and methods for production of specific length fatty alcohols and related compounds
30 Nov 21
The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length.
Robin E. Osterhout, Anthony P. Burgard
Filed: 13 Nov 19
Methods and compositions for producing hydrocarbons
30 Nov 21
Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein.
Andreas W. Schirmer, Mathew A. Rude, Shane A. Brubaker
Filed: 7 Jan 20
Microorganisms and Methods for the Production of Caprolactone
25 Nov 21
The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone.
Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya, Mark J. Burk
Filed: 11 Dec 20
Organisms for the production of 1,3-butanediol
23 Nov 21
A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO.
Anthony P. Burgard, Mark J. Burk, Robin E. Osterhout, Priti Pharkya
Filed: 7 Jun 17
Enhanced Production of Fatty Acid Derivatives
18 Nov 21
Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use.
Zhihao HU, Fernando VALLE
Filed: 5 May 21
Aldehyde Dehydrogenase Variants and Methods of Using Same
11 Nov 21
The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants.
Amit SHAH, Joseph WARNER
Filed: 25 Sep 19