178 patents
Page 2 of 9
Utility
Compositions and Methods for the Biosynthesis of 1,4-BUTANEDIOL and Its Precursors
4 May 23
The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB).
Mark J. Burk, Stephen J. Van Dien, Anthony P. Burgard, Wei Niu
Filed: 19 May 22
Utility
Microorganisms and Methods for Enhancing the Availability of Reducing Equivalents In the Presence of Methanol, and for Producing 3-HYDROXYISOBUTYRATE or Methacrylic Acid Related Thereto
4 May 23
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol.
Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
Filed: 6 Jun 22
Utility
Non-natural Microbial Organisms with Improved Energetic Efficiency
27 Apr 23
The invention provides non-natural microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA, or oxaloacetate and acetyl-CoA.
Priti Pharkya, Anthony P. Burgard, Eric Roland Nunez Van Name
Filed: 17 Jun 22
Utility
Aldehyde dehydrogenase variants and methods of using same
25 Apr 23
The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants.
Amit Shah, Joseph Warner
Filed: 25 Sep 19
Utility
Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,2-propanediol, n-propanol, 1,3-propanediol, or glycerol related thereto
18 Apr 23
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol.
Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
Filed: 17 Jan 18
Utility
Primary alcohol producing organisms
28 Mar 23
The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols.
Jun Sun, Anthony P. Burgard, Priti Pharkya
Filed: 27 May 20
Utility
Microorganisms and Methods for Production of 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL and Related Compounds
2 Mar 23
The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications.
Priti Pharkya, Anthony P. Burgard, Stephen J. Van Dien, Robin E. Osterhout, Mark J. Burk, John D. Trawick, Michael P. Kuchinskas, Brian Steer
Filed: 7 Jul 21
Utility
Microorganisms for producing 1,4-butanediol and methods related thereto
7 Feb 23
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO.
Wei Niu
Filed: 8 Feb 16
Utility
ENGINEERED CELLS FOR PRODUCTION OF CANNABINOIDS AND OTHER MALONYL-CoA-DERIVED PRODUCTS
2 Feb 23
The invention relates to engineered microorganisms (e.g., E. coli) and associated improvements for increasing the production cannabinoids (e.g.
Jingyi Li, Pierre DeWals, Andreas Schirmer, Sankha Ghatak, David Ryan Georgianna
Filed: 25 Nov 20
Utility
Adipate (Ester or Thioester) Synthesis
26 Jan 23
The present invention relates to a method for preparing an adipate ester or thioester.
Liang Wu, Axel Christoph Trefzer, Stefaan Marie Andre De Wildeman, Marco Alexander Van Den Berg
Filed: 2 Jun 22
Utility
Microorganisms and Methods for the Biosynthesis of Adipate, Hexamethylenediamine and 6-AMINOCAPROIC Acid
26 Jan 23
The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway.
Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya
Filed: 16 Nov 21
Utility
Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
27 Dec 22
Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol.
Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
Filed: 21 Oct 13
Utility
Microorganisms and Methods for Increasing Co-factors
22 Dec 22
The present disclosure provides microbial organisms having increased availability of co-factors, such as NADPH, for increasing production of various products, including 1,3-BDO, MMA, (3R)-hydroxybutyl (3R)-hydroxybutyrate, amino acids, 3HB-CoA, adipate, caprolactam, 6-ACA, HMD A, or MAA, and products made from any of these.
Harish Nagarajan, Gionata Scalcinati, Tae Hoon Yang
Filed: 22 Oct 20
Utility
Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
13 Dec 22
A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme.
Mark J. Burk, Anthony P. Burgard, Priti Pharkya
Filed: 19 May 17
Utility
Prenyltransferase Variants and Methods for Production of Prenylated Aromatic Compounds
3 Nov 22
Described herein are non-natural variants of prenyltronsfcrases having at least one amino acid substitution as compared to its corresponding natural or unmodified prenyltransferascs.
Michael A. Noble, Kevin G. Hoff, Russell S. Komor
Filed: 4 Sep 20
Utility
Engineered Transaminase and Methods of Making and Using
3 Nov 22
Disclosed are transaminase (TA) enzymes and nucleic acids encoding them.
Amit M. Shah, Harish Nagarajan, Joseph Roy Warner, Russell Scott Komor
Filed: 24 Apr 20
Utility
Methods for Enhancing Microbial Production of Specific Length Fatty Alcohols In the Presence of Methanol
3 Nov 22
The invention provides non-naturally occurring microbial organisms having a formaldehyde fixation pathway, a formate assimilation pathway, and/or a methanol metabolic pathway in combination with a fatty alcohol, fatty aldehyde, fatty acid or isopropanol pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length or isopropanol.
Robin E. Osterhout, Anthony P. Burgard, Priti Pharkya, Stefan Andrae
Filed: 1 Nov 21
Utility
Microorganisms for the Production of Adipic Acid and Other Compounds
27 Oct 22
The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway.
Anthony P. Burgard, Priti Pharkya, Robin E. Osterhout
Filed: 9 Mar 22
Utility
Engineered Trans-enoyl Coa Reductase and Methods of Making and Using
20 Oct 22
Disclosed are trans-enoyl CoA reductase (TER) enzymes and nucleic acids encoding them.
Amit M. Shah, Harish Nagarajan, Michael Angus Noble
Filed: 24 Apr 20
Utility
Microorganisms and Methods for Production of Specific Length Fatty Alcohols and Related Compounds
20 Oct 22
The invention provides non-naturally occurring microbial organisms containing a fatty alcohol, fatty aldehyde or fatty acid pathway, wherein the microbial organisms selectively produce a fatty alcohol, fatty aldehyde or fatty acid of a specified length.
Robin E. Osterhout, Anthony P. Burgard
Filed: 15 Nov 21