178 patents
Page 3 of 9
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Aldehyde Dehydrogenase Variants and Methods of Use
13 Oct 22
The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants.
Kevin Hoff, Cara Ann Tracewell, Kui Chan, Amit Shah, Joseph Warner, Michael Noble
Filed: 17 Mar 22
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Olivetolic Acid Cyclase Variants and Methods for Their Use
6 Oct 22
Described herein are olivetolic acid cyclases (OAC) including non-natural variants capable of forming a 2,4-dihydroxy-6-alkylbenzoic acid from a 3,5,7-trioxoacyl-CoA or a 3,5,7-trioxocarboxylate substrate.
Michael Angus Noble, Russell Scott Komor
Filed: 5 Jun 20
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Producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam in the presence of methanol using a microorganism having increased availability of reducing equivalents
20 Sep 22
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol.
Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
Filed: 1 Nov 18
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Organisms for the Production of 1,3-BUTANEDIOL
15 Sep 22
A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO.
Anthony P. Burgard, Mark J. Burk, Robin E. Osterhout, Priti Pharkya
Filed: 21 Oct 21
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Methanol dehydrogenase fusion proteins
13 Sep 22
Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase (HPS) or 6-phospho-3-hexuloisomerase (PHI), such as DHAS synthase or fructose-6-Phosphate aldolase or such as DHA synthase or DHA kinase.
Nelson R. Barton, Jingyi Li, Joseph R. Warner, Priti Pharkya
Filed: 27 Oct 16
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Omega-hydroxylase-related fusion polypeptides with improved properties
13 Sep 22
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells.
Baolong Zhu, Andreas W. Schirmer, Cindy Chang
Filed: 16 Jun 15
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Production of fatty acid esters
6 Sep 22
Methods of producing fatty acid esters, such as fatty acid ethyl esters, from genetically engineered microorganisms are described.
Fernando Sanchez-Riera, Stephen Del Cardayre, Fernando Valle
Filed: 27 Dec 18
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Microbial Production Of Fatty Diols
25 Aug 22
The disclosure relates to fatty diols and recombinant microorganisms for producing them.
Andreas W. SCHIRMER, Noah HELMAN, Haibo WANG, Zhihao HU, Vikranth ARLAGADDA, Alma Itzel RAMOS-SOLIS, Elizabeth CLARKE
Filed: 29 Apr 22
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Omega-hydroxylase-related fusion polypeptides with improved properties
23 Aug 22
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells.
Baolong Zhu, Andreas W. Schirmer, Cindy Chang
Filed: 23 Oct 19
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Methods And Compositions For Producing Hydrocarbons
18 Aug 22
Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein.
Andreas W. SCHIRMER, Mathew A. RUDE, Shane A. BRUBAKER
Filed: 22 Oct 21
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Thioesterase Variants Having Improved Activity For The Production Of Medium-Chain Fatty Acid Derivatives
4 Aug 22
The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives.
Angelica Zabala BAUTISTA, Min Sun PARK, Alma Itzel RAMOS-SOLIS, Bernardo Moura TORRES DA COSTA, Behnaz BEHROUZIAN, Donald E. TRIMBUR, Emanuela POPOVA, Qijun HU, Stephen Bralley DEL CARDAYRE
Filed: 7 Apr 22
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Microorganisms for the production of 1,4- butanediol and related methods
2 Aug 22
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO.
Stephen J. Van Dien, Anthony P. Burgard, Robert Haselbeck, Catherine J. Pujol-Baxley, Wei Niu, John D. Trawick, Harry Yim, Mark J. Burk, Robin E. Osterhout, Jun Sun
Filed: 6 Mar 19
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Engineered Microorganisms and Methods for Improved Aldehyde Dehydrogenase Activity
28 Jul 22
Disclosed are biosynthetic methods and engineered microorganism that enhance or improve the biosynthesis of hexamethylenediamine, caproic acid or caprolactam.
Amit M. Shah, Harish Nagarajan
Filed: 24 Apr 20
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Microorganisms and Methods for Producing Butadiene and Related Compounds by Formate Assimilation
14 Jul 22
Provided herein are non-naturally occurring microbial organisms having a formaldehyde fixation pathway and a formate assimilation pathway, which can further include a methanol metabolic pathway, a methanol oxidation pathway, a hydrogenase and/or a carbon monoxide dehydrogenase.
Anthony P. BURGARD, Robin E. OSTERHOUT, Priti PHARKYA, Stefan ANDRAE
Filed: 4 Aug 21
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Alcohol dehydrogenase variants
12 Jul 22
Described herein are non-natural NAD+-dependent alcohol dehydrogenases (ADHs) capable of at least two fold greater conversion of methanol or ethanol to formaldehyde or acetaldehyde, respectively, as compared to its unmodified counterpart.
Stefan Andrae, Michael Patrick Kuchinskas, Jingyi Li, Harish Nagarajan, Priti Pharkya
Filed: 17 Feb 20
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Omega-hydroxylase-related fusion polypeptide variants with improved properties
12 Jul 22
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells.
Andreas Schirmer, Baolong Zhu, Emanuela Popova
Filed: 24 Aug 20
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Adipate (ester or thioester) synthesis
21 Jun 22
The present invention relates to a method for preparing an adipate ester or thioester.
Liang Wu, Axel Christoph Trefzer, Stefaan Marie Andre De Wildeman, Marco Alexander Van Den Berg
Filed: 17 Sep 19
Utility
Microbial production of fatty diols
14 Jun 22
The disclosure relates to fatty diols and recombinant microorganisms for producing them.
Andreas W. Schirmer, Noah Helman, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel Ramos-Solis, Elizabeth Clarke
Filed: 1 Jun 20
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Olivetol Synthase Variants and Methods for Production of Olivetolic Acid and Its Analog Compounds
9 Jun 22
Described herein are non-natural olivetol synthase (OLS) variants, nucleic acids, engineered cells, method s for preparing cannabinoids, and compositions thereof.
Michael A. Noble, Russell Scott Komor, Jingyi Li
Filed: 17 Apr 20
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Engineered Microorganisms with G3P -> 3PG Enzyme And/or FRUCTOSE-1,6-BISPHOSPHATASE Including Those Having Synthetic or Enhanced Methylotrophy
9 Jun 22
Described herein are engineered cells including ones having synthetic methylotrophy which include an NADH-dependent enzyme capable of converting G3P to 3PG (e.g., B. methanolicus gapN) and/or fructose-1,6-bisphosphatase, along with hexulose-6-phosphate synthase, 6-phospho-3-hexuloisomerase, a phosphoketolase, or a combination thereof.
Harish Nagarajan, Tae Hoon Yang, Ali Khodayari
Filed: 26 Jun 19