178 patents
Page 5 of 9
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Aldehyde Dehydrogenase Variants and Methods of Using Same
11 Nov 21
The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants.
Amit SHAH, Joseph WARNER
Filed: 25 Sep 19
Utility
Production Of Fatty Acid Derivatives
11 Nov 21
The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives.
Derek L. GREENFIELD, Andreas W. SCHIRMER, Elizabeth J. CLARKE, Eli S. GROBAN, Bernardo M. DA COSTA, Zhihao HU, Kevin HOLDEN, Noah HELMAN
Filed: 1 Jun 21
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1,3-fatty diol compounds and derivatives thereof
9 Nov 21
The disclosure relates to the field of specialty chemicals.
Haibo Wang
Filed: 10 Jan 20
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Microorganisms and Methods for Improving Product Yields on Methanol Using Acetyl-coa Synthesis
28 Oct 21
The invention provides non-naturally occurring microbial organisms containing enzymatic pathways and/or metabolic modifications for enhancing carbon flux through acetyl-CoA.
Robin E. Osterhout, Anthony P. Burgard, Priti Pharkya, Stefan Andrae
Filed: 6 Oct 20
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Methods And Compositions For Producing Fatty Alcohols
21 Oct 21
Methods and compositions, including nucleotide sequences, amino acid sequences, and host cells, for producing fatty alcohols are described.
Zhihao HU, Vikranth ARLAGADDA
Filed: 1 Feb 21
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Downstream Processing Of Fatty Alcohol Compositions Produced By Recombinant Host Cells
21 Oct 21
The disclosure relates to downstream processing of fatty alcohol (FALC) and provides a novel purification method that provides FALC at high purity and yield.
Myong KO, Haibo WANG, Patricia J. COLE, Perry Y. LIAO, Simon LI
Filed: 25 May 21
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Production Of Odd Chain Fatty Acid Derivatives In Recombinant Microbial Cells
21 Oct 21
Recombinant microbial cells are provided which have been engineered to produce fatty acid derivatives having linear chains containing an odd number of carbon atoms by the fatty acid biosynthetic pathway.
Grace J. LEE, John HALIBURTON, Zhihao HU, Andreas W. SCHIRMER, Kevin HOLDEN
Filed: 8 Feb 21
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Acetyl-CoA carboxylase variants
12 Oct 21
The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives.
Derek L. Greenfield, Donald E. Trimbur, Andreas W. Schirmer, Cindy Chang, Behnaz Behrouzian, Jessica Winger
Filed: 26 Feb 20
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Enzyme Variants With Improved Ester Synthase Properties
7 Oct 21
The disclosure relates to enzyme variants with improved ester synthase properties for the production of fatty acid esters.
Andrew M. SHUMAKER, Bernardo M. DA COSTA, Kevin HOLDEN, Louis G. HOM, Tarah S. BARON, Noah HELMAN
Filed: 9 Dec 20
Utility
Semisynthetic Routes to Organic Compounds
7 Oct 21
The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.
Stephen B. DEL CARDAYRE, Andreas W. SCHIRMER, Myong KO, Haibo WANG
Filed: 13 Apr 21
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Acyl-ACP reductase with improved properties
28 Sep 21
The disclosure relates to acyl-ACP reductase (AAR) enzyme variants that result in improved fatty aldehyde and fatty alcohol production when expressed in recombinant host cells.
Mathew Rude, Na Trinh, Andreas Schirmer, Jacob Gano
Filed: 11 Feb 19
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Engineered Microorganisms & Methods for Improved Crotyl Alcohol Production
9 Sep 21
Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol.
Stephanie J. Culler, Nicholas Eakley, Kevin Gregory Hoff, Robin E. Osterhout, Priti Pharkya, Erik C. Ralph, Stephen J. Van Dien
Filed: 19 Nov 20
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Prenyltransferase Variants and Methods for Production of Prenylated Aromatic Compounds
19 Aug 21
Described herein are prenyltransferases including non-natural variants thereof having at least one amino acid substitution as compared to its corresponding natural or unmodified prenyltransferases and that are capable of at least two-fold greater rate of formation of cannabinoids such as cannabigerolic acid, cannabigerovarinic acid, cannabigerorcinic acid, and cannabigerol, as compared to a wild type control.
Michael A. Noble, Kevin G. Hoff, Anna Lechner, Harish Nagarajan
Filed: 8 Mar 19
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Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
10 Aug 21
The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications.
Priti Pharkya, Anthony P. Burgard, Stephen J. Van Dien, Robin E. Osterhout, Mark J. Burk, John D. Trawick, Michael P. Kuchinskas, Brian Steer
Filed: 2 May 17
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Multicellular Metabolic Models and Methods
5 Aug 21
The invention provides a computer readable medium or media, having: (a) a first data structure relating a plurality of reactants to a plurality of reactions from a first cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (b) a second data structure relating a plurality of reactants to a plurality of reactions from a second cell, each of said reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (c) a third data structure relating a plurality of intra-system reactants to a plurality of intra-system reactions between said first and second cells, each of said intra-system reactions comprising a reactant identified as a substrate of the reaction, a reactant identified as a product of the reaction and a stoichiometric coefficient relating said substrate and said product; (d) a constraint set for said plurality of reactions for said first, second and third data structures, and (e) commands for determining at least one flux distribution that minimizes or maximizes an objective function when said constraint set is applied to said first and second data structures, wherein said at least one flux distribution is predictive of a physiological function of said first and second cells.
Imandokht Famili, Christophe H. Schilling
Filed: 11 Sep 20
Utility
Microorganisms and Methods for Producing Butadiene and Related Compounds by Formate Assimilation
5 Aug 21
Provided herein are non-naturally occurring microbial organisms having a FaldFP, a FAP and/or metabolic modifications which can further include a MMP, a MOP, a hydrogenase and/or a CODH.
Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya, Stefan Andrae, Ewa Teresa Lis, Carla Risso, John Douglas Trawick
Filed: 31 Aug 20
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Omega-hydroxylase-related Fusion Polypeptide Variants with Improved Properties
29 Jul 21
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells.
Andreas Schirmer, Baolong ZHU, Emanuela Popova
Filed: 24 Aug 20
Utility
Methods and compositions for improved production of fatty acids and derivatives thereof
20 Jul 21
The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, and engineered host cells for producing fatty acids and derivates of fatty acids such as acyl-CoA, terminal olefins, fatty aldehydes, fatty alcohols, alkanes, alkenes, wax esters, ketones and internal olefins through altered expression of the transcription factor, fadR.
Derek L. Greenfield, Louis G. Hom, Fernando A. Sanchez-Riera, Zhihao Hu, Vikranth Arlagadda, Eli S. Groban, Scott A. Frykman
Filed: 2 Apr 12
Utility
Production of fatty acid derivatives
13 Jul 21
The invention relates to compositions and methods, including polynucleotide sequences, amino acid sequences, recombinant host cells and recombinant host cell cultures engineered to produce fatty acid derivative compositions comprising fatty acids, fatty alcohols, fatty aldehydes, fatty esters, alkanes, terminal olefins, internal olefins or ketones.
Derek L. Greenfield, Andreas W. Schirmer, Elizabeth J. Clarke, Eli S. Groban, Bernardo M. Da Costa, Zhihao Hu, Kevin Holden, Noah Helman
Filed: 14 Jul 17
Utility
Thioesterase Variants Having Improved Activity for the Production of Medium-chain Fatty Acid Derivatives
8 Jul 21
The disclosure relates to engineered plant acyl-ACP thioesterases having improved activity for the production of medium-chain fatty acid derivatives including e.g., eight carbon and ten carbon fatty acids and fatty acid derivatives.
Angelica Zabala BAUTISTA, Min Sun PARK, Alma Itzel RAMOS-SOLIS, Bernardo Moura TORRES DA COSTA, Behnaz BEHROUZIAN, Donald E. TRIMBUR, Emanuela POPOVA, Qijun HU, Stephen Bralley DEL CARDAYRE
Filed: 3 Apr 18