73 patents
Utility
Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
5 Dec 23
The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway.
Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya
Filed: 16 Nov 21
Utility
Recombinant microorganisms for the production of fatty amines
14 Nov 23
The disclosure relates to recombinant microorganisms for the production of fatty amines and derivatives thereof.
Stephen B. Del Cardayre, Louis G. Hom
Filed: 14 Dec 20
Utility
Microorganisms and methods for producing (3R)-hydroxybutyl (3R)-hydroxybutyrate
14 Nov 23
Provided herein are non-naturally occurring microbial organisms having a pathway for production of (3R)-hydroxybutyl (3R)-hydroxybutyrate, wherein the organism can further include a (R)-1,3-butanediol pathway, a (3R)-hydroxybutyrate pathway, a (3R)-hydroxybutyryl-CoA pathway, an acetoacetate pathway, an acetoacetyl-CoA pathway, a (3R)-hydroxybutyl-ACP pathway, or an acetoacetyl-ACP pathway.
Benjamin Adelstein, Robin E. Osterhout, Mark J. Burk
Filed: 23 May 14
Utility
Process for the production of epsilon caprolactam from 6-aminocaproic acid
12 Sep 23
A new process for the production of epsilon caprolactam (CPL) from 6-aminocaproic acid (6-ACA) can be obtained either from traditional petro chemical processes or can be obtained from biochemical processes.
Michele Cecchetto, Anacleto Dal Moro, Lauri Hannunpoika Suominen, Michael Japs
Filed: 23 Dec 19
Utility
Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam related thereto
12 Sep 23
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol.
Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
Filed: 16 Dec 13
Utility
Microorganisms for producing 1,3-butanediol and methods related thereto
25 Jul 23
Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO.
Anthony P. Burgard, Mark J. Burk, Robin E. Osterhout, Jun Sun, Priti Pharkya
Filed: 5 Jun 20
Utility
Microorganisms and methods for the production of caprolactone
25 Jul 23
The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a sufficient amount to produce caprolactone.
Anthony P. Burgard, Robin E. Osterhout, Priti Pharkya, Mark J. Burk
Filed: 11 Dec 20
Utility
Method of producing and processing diamines to a diamine free base using a carbonate intermediate and an engineered microorganism
18 Jul 23
Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.
Lauri H. Suominen, Connor J. Galleher, Michael Japs, Mark J. Burk, Cara Tracewell
Filed: 13 Jul 20
Utility
Prenyltransferase variants and methods for production of prenylated aromatic compounds
27 Jun 23
Described herein are prenyltransferases including non-natural variants thereof having at least one amino acid substitution as compared to its corresponding natural or unmodified prenyltransferases and that are capable of at least two-fold greater rate of formation of cannabinoids such as cannabigerolic acid, cannabigerovarinic acid, cannabigerorcinic acid, and cannabigerol, as compared to a wild type control.
Michael A. Noble, Kevin G. Hoff, Anna Lechner, Harish Nagarajan
Filed: 8 Mar 19
Utility
Aldehyde dehydrogenase variants and methods of using same
25 Apr 23
The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants.
Amit Shah, Joseph Warner
Filed: 25 Sep 19
Utility
Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing 1,2-propanediol, n-propanol, 1,3-propanediol, or glycerol related thereto
18 Apr 23
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol.
Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
Filed: 17 Jan 18
Utility
Primary alcohol producing organisms
28 Mar 23
The invention provides a non-naturally occurring microbial organism having a microbial organism having at least one exogenous gene insertion and/or one or more gene disruptions that confer production of primary alcohols.
Jun Sun, Anthony P. Burgard, Priti Pharkya
Filed: 27 May 20
Utility
Microorganisms for producing 1,4-butanediol and methods related thereto
7 Feb 23
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO.
Wei Niu
Filed: 8 Feb 16
Utility
Microorganisms and methods for enhancing the availability of reducing equivalents in the presence of methanol, and for producing succinate related thereto
27 Dec 22
Provided herein is a non-naturally occurring microbial organism (NNOMO) having a methanol metabolic pathway (MMP) that can enhance the availability of reducing equivalents in the presence of methanol.
Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
Filed: 21 Oct 13
Utility
Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
13 Dec 22
A non-naturally occurring eukaryotic or prokaryotic organism includes one or more gene disruptions occurring in genes encoding enzymes imparting increased fumarate, malate or acrylate production in the organism when the gene disruption reduces an activity of the enzyme.
Mark J. Burk, Anthony P. Burgard, Priti Pharkya
Filed: 19 May 17
Utility
Producing adipate, 6-aminocaproate, hexamethylenediamine or caprolactam in the presence of methanol using a microorganism having increased availability of reducing equivalents
20 Sep 22
Provided herein is a non-naturally occurring microbial organism having a methanol metabolic pathway that can enhance the availability of reducing equivalents in the presence of methanol.
Anthony P. Burgard, Robin E. Osterhout, Stephen J. Van Dien, Cara Ann Tracewell, Priti Pharkya, Stefan Andrae
Filed: 1 Nov 18
Utility
Methanol dehydrogenase fusion proteins
13 Sep 22
Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase (HPS) or 6-phospho-3-hexuloisomerase (PHI), such as DHAS synthase or fructose-6-Phosphate aldolase or such as DHA synthase or DHA kinase.
Nelson R. Barton, Jingyi Li, Joseph R. Warner, Priti Pharkya
Filed: 27 Oct 16
Utility
Omega-hydroxylase-related fusion polypeptides with improved properties
13 Sep 22
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells.
Baolong Zhu, Andreas W. Schirmer, Cindy Chang
Filed: 16 Jun 15
Utility
Production of fatty acid esters
6 Sep 22
Methods of producing fatty acid esters, such as fatty acid ethyl esters, from genetically engineered microorganisms are described.
Fernando Sanchez-Riera, Stephen Del Cardayre, Fernando Valle
Filed: 27 Dec 18
Utility
Omega-hydroxylase-related fusion polypeptides with improved properties
23 Aug 22
The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells.
Baolong Zhu, Andreas W. Schirmer, Cindy Chang
Filed: 23 Oct 19