23 patents
Utility
Methods of treating liver disorders or lipid disorders with a THR-beta agonist
7 Nov 23
The present invention provides a method for treating a liver disorder or lipid disorder in a subject in need thereof with 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile, a stereoisomer, a salt thereof, or a morphic form thereof.
Rebecca Taub
Filed: 7 Jul 21
Utility
Methods of Synthesizing Thyroid Hormone Analogs and Polymorphs Thereof
6 Jul 23
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs.
D. Keith HESTER, II, Robert J. DUGUID, Martha J. KELLY, Anna CHASNOFF, Gang DONG, Edwin L. CROW, Lianhe SHU, Ping WANG, Duk Soon CHOI
Filed: 15 Dec 22
Utility
Combination Therapies Comprising Targeted Therapeutics
16 Feb 23
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Weiwen Ying, Dinesh U. Chimmanamada, David Proia
Filed: 27 Sep 22
Utility
Methods of synthesizing thyroid hormone analogs and polymorphs thereof
31 Jan 23
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs.
D. Keith Hester, II, Robert J. Duguid, Martha J. Kelly, Anna Chasnoff, Gang Dong, Edwin L. Crow, Lianhe Shu, Ping Wang, Duk Soon Choi
Filed: 11 Dec 20
Utility
Combination therapies comprising targeted therapeutics
8 Nov 22
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Weiwen Ying, Dinesh U. Chimmanamada, David Proia
Filed: 19 Jun 18
Utility
Targeted Therapeutics
15 Sep 22
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Neera Jain, Weiwen Ying, Dinesh U. Chimmanamada, Junyi Zhang, Amit Kale
Filed: 26 May 22
Utility
Targeted therapeutics
5 Jul 22
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Neera Jain, Weiwen Ying, Dinesh U. Chimmanamada, Junyi Zhang, Amit Kale
Filed: 19 Jun 18
Utility
Methods of Treating Liver Disorders or Lipid Disorders with a Thr-beta Agonist
28 Oct 21
The present invention provides a method for treating a liver disorder or lipid disorder in a subject in need thereof with 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile, a stereoisomer, a salt thereof, or a morphic form thereof.
Rebecca TAUB
Filed: 7 Jul 21
Utility
Methods of treating liver disorders or lipid disorders with a THR-beta agonist
17 Aug 21
The present invention provides a method for treating a liver disorder or lipid disorder in a subject in need thereof with 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile, a stereoisomer, a salt thereof, or a morphic form thereof.
Rebecca Taub
Filed: 18 Oct 17
Utility
Methods of Synthesizing Thyroid Hormone Analogs and Polymorphs Thereof
3 Jun 21
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs.
D. Keith HESTER, II, Robert J. DUGUID, Martha J. KELLY, Anna CHASNOFF, Gang DONG, Edwin L. CROW, Lianhe SHU, Ping WANG, Duk Soon CHOI
Filed: 11 Dec 20
Utility
Methods of Treating Neurological Diseases and Disorders
13 May 21
The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NFκB and/or the amount of IκB.
Rongzhen Lu, James Barsoum, Yumiko Wada
Filed: 14 Aug 20
Utility
Solid Forms of 2-(3,5-DICHLORO-4-((5-ISOPROPYL-6-OXO-1,6-DIHYDROPYRIDAZIN-3-YL)OXY)PHENYL)-3,5-DIOXO-2,3,4,5-TETRAHYDRO-1,2,4-TRIAZINE-6-CARBONITRILE
29 Apr 21
The present invention is directed to morphic forms, co-crystals, salts, and amorphous solid dispersions of 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile.
Mahmoud MIRMEHRABI, Marco JONAS, Pavan Karthik BATCHU
Filed: 2 Jul 19
Utility
Targeted Therapeutics
25 Mar 21
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Dinesh U. Chimmanamada, Weiwen Ying, Junyi Zhang, Teresa Kowalczyk-Przewloka, Jun Jiang, Sami Osman, Genliang Lu, Dharma Vutukuri, James Loch, Shoujun Chen
Filed: 23 Sep 20
Utility
Methods of synthesizing thyroid hormone analogs and polymorphs thereof
19 Jan 21
The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs.
D. Keith Hester, II, Robert J. Duguid, Martha J. Kelly, Anna Chasnoff, Gang Dong, Edwin L. Crow, Lianhe Shu, Ping Wang, Duk Soon Choi
Filed: 1 Jul 19
Utility
Targeted therapeutics
9 Nov 20
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Dinesh U. Chimmanamada, Weiwen Ying, Junyi Zhang, Teresa Kowalczyk-Przewloka, Jun Jiang, Sami Osman, Genliang Lu, Dharma Vutukuri, James Loch, Shoujun Chen
Filed: 7 Mar 16
Utility
Targeted Therapeutics
7 Oct 20
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Dinesh U. Chimmanamada, Weiwen Ying
Filed: 25 May 20
Utility
Targeted Therapeutics
29 Jul 20
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Neera Jain, Weiwen Ying, Dinesh U. Chimmanamada, Junyi Zhang, Amit Kale
Filed: 18 Jun 18
Utility
Targeted therapeutics
27 Jul 20
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Dinesh U. Chimmanamada, Weiwen Ying
Filed: 18 Jan 17
Utility
Methods of Treating Liver Disorders or Lipid Disorders with a Thr-beta Agonist
22 Jul 20
The present invention provides a method for treating a liver disorder or lipid disorder in a subject in need thereof with 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile, a stereoisomer, a salt thereof, or a morphic form thereof.
Rebecca TAUB
Filed: 17 Oct 17
Utility
Combination Therapies Comprising Targeted Therapeutics
15 Jul 20
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest.
Weiwen Ying, Dinesh U. Chimmanamada, David Proia
Filed: 18 Jun 18