8 patents
Utility
Preparation of mammalian oocyte for fertilization via a soluble human PH20 hyaluronidase polypeptide
15 Aug 23
Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration for in vitro fertilization, as well as administration of molecules, or to alleviate glycosaminoglycan associated pathologies.
Louis H. Bookbinder, Anirban Kundu, Gregory I. Frost
Filed: 2 Oct 20
Utility
Compositions of adenosine deaminase-2 (ADA2), variants thereof and methods of using same
21 Feb 23
Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates.
Christopher D. Thanos, Lin Wang, H. Michael Shepard
Filed: 29 Mar 18
Utility
Combination therapy with a hyaluronan-degrading enzyme and an immune checkpoint inhibitor
16 Aug 22
Provided are methods of treatments with combinations or compositions containing a soluble hyaluronidase, such as a polymer-modified hyaluronidase, and an immune checkpoint inhibitor treating cancers, including solid and non-solid tumors.
Sanna Rosengren, H. Michael Shepard, Curtis B. Thompson
Filed: 27 Feb 17
Utility
PH20 polypeptide variants, formulations and uses thereof
20 Jul 21
Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided.
Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
Filed: 25 Jun 20
Utility
PH20 polypeptide variants, formulations and uses thereof
22 Jun 21
Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided.
Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
Filed: 19 Mar 20
Utility
Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof
26 Jan 21
Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies.
Louis H. Bookbinder, Anirban Kundu, Gregory I. Frost
Filed: 2 Apr 19
Utility
PH20 polypeptide variants, formulations and uses thereof
14 Dec 20
Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided.
Ge Wei, H. Michael Shepard, Qiping Zhao, Robert James Connor
Filed: 1 Aug 16
Utility
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
16 Mar 20
The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies.
Louis H. Bookbinder, Anirban Kundu, Gregory I. Frost
Filed: 22 Feb 18
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