28 patents
Utility
Inductively Coupled Plasma Based Atomic Analysis Systems and Methods
21 Dec 23
Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized.
Alexander Loboda, Raymond Jong, Michael Sullivan, Serguei Vorobiev, Robert Rotenberg, Emil D. Stratulativ, Maxim Voronov, Mark Armstrong
Filed: 28 Aug 23
Utility
Mass Cytometry Reagents and Methods for Signal Amplification
27 Jul 23
Described herein are reagents and methods for improving signal in imaging mass cytometry.
Bedilu ALLO, Xudong LOU, Peng LIU, Daniel MAJONIS, Anastasia MAVROPOULOS, Ladan GHEIRATMAND
Filed: 18 Dec 20
Utility
Plasma and Sampling Geometries for Imaging Mass Cytometry
6 Jul 23
Described herein are systems and methods for imaging mass spectrometry, including imaging mass cytometry.
Adam Carew, Daaf Sandkuijl, Alexander Loboda, Matthew Weel, Dmitry Bandura
Filed: 21 Dec 20
Utility
Automated and High Throughput Imaging Mass Cytometry
19 Jan 23
Methods and systems for automated slide handling for imaging applications are described herein.
Daaf Sandkuijl, Alexander Loboda, Vincent Yi-Ching Yeh, Ladan Gheiratmand
Filed: 25 Nov 20
Utility
Method and Systems for Microfluidic Logic Devices
15 Dec 22
A microfluidic device includes an input source characterized by a source pressure, an input channel in fluid communication with the input source, and an output channel.
Naga Gopi Devaraju, Marc A. Unger
Filed: 27 Jun 22
Utility
Improved Mass Cytometry
29 Sep 22
Embodiments of the present invention relate to replacement of the previous ICP-based ionisation system with a new laser ionisation system, providing improved mass spectrometer-based apparatus and methods for using them to analyse samples, in particular the use of mass spectrometry mass cytometry, imaging mass spectrometry and imaging mass cytometry, for the analysis of biological samples.
Paul Corkum, Alexander Loboda, David M. Rayner
Filed: 17 Jun 20
Utility
Additional Mass Tag Polymers for Mass Cytometry
15 Sep 22
A new class of mass-tag polymers is provided, which include enriched metal isotopes such as zirconium and hafnium mass tags.
Peng Liu, Daniel Majonis, Vladimir Baranov, Mitchel A. Winnik, Hyungjun Cho
Filed: 7 Aug 20
Utility
High Resolution Imaging Apparatus and Method
14 Jul 22
The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC™) in which labelling atoms are detected by IMS.
Paul Corkum, Alexander V. Loboda
Filed: 21 Jan 22
Utility
Sample Analysis for Mass Cytometry
9 Jun 22
The invention relates to methods and devices for analysis of samples using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).
Alexander V. Loboda
Filed: 22 Jul 21
Utility
High-level Multiplex Amplification
24 Mar 22
The present disclosure provides a “looping amplification” method to increase the specificity of nucleic acid amplification.
Peilin Chen
Filed: 10 Aug 21
Utility
Inductively Coupled Plasma Based Atomic Analysis Systems and Methods
24 Mar 22
Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized.
Alexander Loboda, Raymond Jong, Michael Sullivan, Serguei Vorobiev, Robert Rotenberg, Emil D. Stratulativ, Maxim Voronov, Mark Armstrong
Filed: 9 Sep 21
Utility
Parallelized Sample Processing and Library Prep
20 Jan 22
Described herein are methods, kits and systems for sample enrichment, multi-step library preparation, sample normalization, detection of sample biomolecules and combinations thereof.
Michael L. Phelan, Christopher J. Kubu, Brian Fowler, Gang Sun, Nikita Patel, Naveen Ramalingam
Filed: 28 May 21
Utility
Inductively Coupled Plasma Torch with Reverse Vortex Flow and Method of Operation
30 Dec 21
We describe in this application the analysis of samples using elemental or mass spectrometry and the analysis of samples, such as biological samples by suspension mass cytometry or imaging mass cytometry and an inductively coupled plasma torch with reverse vortex flow for elemental analysis and a method of operating an ICP torch configured to interface with a spectrometer.
Alexander V. Loboda, Adam Carew
Filed: 28 Oct 19
Utility
Direct Ionization In Imaging Mass Spectrometry Operation
16 Dec 21
As described herein, one or more parameters of a direct ionization imaging mass spectrometer (IMS) may be set to obtain a desired plasma and deliver it to a mass detector.
Alexander Loboda, Daaf Sandkuijl, Adam Carew
Filed: 14 Jan 20
Utility
Autofocus Sample Imaging Apparatus and Method
2 Dec 21
We describe in this application systems and methods for autofocusing in imaging mass spectrometry.
DAAF SANDKUIJL, Alexander V. Loboda, ADAM CAREW, KHASHAYAR ASKARPOUR
Filed: 10 Sep 19
Utility
Fused-reference Particle Based Normalisation for Imaging Mass Spectrometry
18 Nov 21
This disclosure relates to reagents and their use for elemental imaging mass spectrometry of biological samples.
Taunia Closson, Vladimir Baranov, Mitchell A. Winnik
Filed: 9 Sep 19
Utility
High Speed Modulation Sample Imaging Apparatus and Method
28 Oct 21
This disclosure relates to systems and methods for high speed modulation sample imaging.
DAAF SANDKUIJL, Alexander V. Loboda, ADAM CAREW, MINALINI LAKSHMAN
Filed: 10 Sep 19
Utility
Multi-primer Amplification Method for Barcoding of Target Nucleic Acids
21 Oct 21
In certain embodiments, the present invention provides amplification methods in which nucleotide tag(s) and, optionally, a barcode nucleotide sequence are added to target nucleotide sequences.
Andrew May, Peilin Chen, Jun Wang, Fiona Kaper, Megan Anderson
Filed: 3 Feb 21
Utility
Parallelized Sample Processing and Library Prep
2 Sep 21
Described herein are methods, kits and systems for sample enrichment, multi-step library preparation, sample normalization, detection of sample biomolecules and combinations thereof.
Michael L. Phelan, Christopher J. Kubu, Brian Fowler, Gang Sun, Nikita Patel, Naveen Ramalingam
Filed: 22 Feb 21
Utility
Method for Capturing and Encoding Nucleic Acid from a Plurality of Single Cells
19 Aug 21
This invention relates to methods for capturing and encoding nucleic acid from a plurality of single cells.
Sten Linnarsson, Gioele Le Manno, Amit Zeisel
Filed: 8 Oct 20