13 patents
Utility
Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules
28 Nov 23
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.
Tamaz Guliashvili, Thomas Golobish, Maryann Gruda, Pamela O'Sullivan, Andrew Scheirer, Vincent Capponi, Phillip Chan, Wei-Tai Young
Filed: 12 Jul 21
Utility
Hemocompatibility modifiers for cross-linked polymeric material
12 Sep 23
The invention concerns methods of treating blood, blood product, or physiologic fluid to provide at least one of (i) increasing shelf life of the blood, blood product or physiologic fluid, (ii) maintaining freshness of new blood, blood product or physiologic fluid, and (iii) removing undesirable molecules from the blood, blood product or physiologic fluid; said method comprising contacting said blood, blood product or physiologic fluid with a sorbent, said sorbent being primarily in a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of at least one of (1) zwitterionic moieties and (2) oligo(ethylene glycol) moieties attached to the surface of said cross-linked polymeric material.
Thomas D. Golobish, Vincent J. Capponi, David R. Clay
Filed: 31 Mar 14
Utility
Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids
15 Aug 23
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
Filed: 8 Jun 21
Utility
Methods for reducing contamination in a biological substance
14 Mar 23
Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin.
Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 26 Apr 17
Utility
Methods for removal of toxins from blood using an extracorporeal circuit comprised of a hollow-fiber filter module and polymer sorbent in combination
21 Dec 21
This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
Wei-Tai Young, Tamaz Guliashvili, Andrew Scheirer, Josh Vichare, Timothy Kovacs, Maryann Gruda, Thomas Golobish, Vincent Capponi, Phillip Chan
Filed: 22 Mar 18
Utility
Use of a hemocompatible porous polymer bead sorbent for removal of endotoxemia-inducing molecules
20 Jul 21
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules.
Tamaz Guliashvili, Thomas Golobish, Maryann Gruda, Pamela O'Sullivan, Andrew Scheirer, Vincent Capponi, Phillip Chan, Wei-Tai Young
Filed: 18 May 17
Utility
Method of treating inflammation
13 Jul 21
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient.
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 3 Jun 16
Utility
Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids
22 Jun 21
The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
Thomas Golobish, Maryann Gruda, Tamaz Guliashvili, Pamela O'Sullivan, Andrew Scheirer, Vi Dan, Wei-Tai Young, Vincent Capponi, Phillip Chan
Filed: 21 Oct 16
Utility
Hemocompatibility modifiers for cross-linked polymeric material
1 Jun 21
The invention concerns methods of removing undesirable molecules from the blood or physiologic fluid; said method comprising contacting said blood or physiologic fluid with a sorbent, said sorbent comprising a plurality of solid forms and comprising a cross-linked polymeric material having a plurality of ligands attached to the surface of said cross-linked polymeric material, comprising (i) zwitterionic moieties, (ii) oligo(ethylene glycol) moieties or (iii) mixtures thereof; said contacting comprising said sorbent sorbing a plurality of said undesirable molecules when said sorbent is administered within a patient's body.
Thomas D. Golobish, Vincent J. Capponi, David R. Clay
Filed: 17 Apr 20
Utility
Method of treating inflammation
6 Apr 21
The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient.
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 26 Jun 18
Utility
Method of treating inflammation
16 Mar 21
The present invention concerns methods of administering a therapeutically effective dose of a sorbent for an inflammatory mediator to a patient where the inflammatory mediator is one or more of enzymes, cytokines, prostaglandins, eicosanoids, leukotrienes, kinins, complement, coagulation factors, endotoxins, enterotoxins, lipopolysaccharide, cell fragments, bile salts, fatty acids, phospholipids, interferon and immunomodulatory antibodies, biologics or drugs.
Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 29 May 19
Utility
Process for functionalizing a biocompatible polymeric bead, the functionalized beads, and the beads produced thereby
12 Jan 21
The invention involves functionalizing polymeric beads, such as DVB beads, to add an epoxide or aldehyde group.
Thomas Golobish, Tamaz Guliashvili, Vincent Capponi
Filed: 10 May 19
Utility
Polymeric sorbent for removal of impurities from whole blood and blood products
30 Sep 19
The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as non¬ hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
Filed: 9 Aug 12
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