304 patents
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Biocatalysts for the Preparation of Hydroxy Substituted Carbamates
18 Jan 24
The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.
Fabien Louis Cabirol, Haibin Chen, Anupam Gohel, Steven J. Collier, Derek J. Smith, Birgit Kosjek, Jacob Janey
Filed: 12 Jun 23
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Engineered Leucine Decarboxylases
18 Jan 24
The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase (LDC) polypeptides.
Joyce Liu, Leann Quertinmont Teadt, Nikki Dellas, Stephan Jenne, Faye Loan Du, Kristen Jean Vallieu, Kerryn McCluskie
Filed: 2 Aug 23
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Engineered Glycosyltransferases and Steviol Glycoside Glucosylation Methods
11 Jan 24
The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jonathan Vroom, Stephanie Sue Galanie, Jack Liang, Joyce Liu, Nikki Dellas, Melissa Ann Mayo, David Entwistle
Filed: 2 Aug 23
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Engineered Pantothenate Kinase Variant Enzymes
4 Jan 24
The present invention provides engineered pantothenate kinase (PanK) enzymes, polypeptides having PanK activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jovana Nazor, Mikayla Jianghongxia Krawczyk, Zara Maxine Seibel, Nandhitha Subramanian, Joshua Kolev
Filed: 29 Sep 21
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Engineered Transaminase Polypeptides
4 Jan 24
The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions.
Scott J. Novick, Nikki Dellas
Filed: 1 Sep 23
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Engineered deoxyribose-phosphate aldolases
19 Dec 23
The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.
Da Duan, Oscar Alvizo, Jovana Nazor, Harvinder Chagger Maniar, James Nicholas Riggins, Jonathan Vroom, Santhosh Sivaramakrishnan, Hao Yang, Anna Fryszkowska, Mark A. Huffman, Joshua N. Kolev, Iman Farasat, Agustina Rodriguez-Granillo, Deeptak Verma
Filed: 4 Feb 22
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Engineered Phosphopentomutase Variant Enzymes
23 Nov 23
The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jonathan Vroom, Santhosh Sivaramakrishnan, Jessica Anna Hurtak
Filed: 5 Oct 21
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Engineered Galactose Oxidase Variant Enzymes
23 Nov 23
The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Margie Tabuga Borra-Garske, Jovana Nazor, Nandhitha Subramanian, Oscar Alvizo, Anna Fryszkowska
Filed: 1 Oct 21
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P450-BM3 variants with improved activity
7 Nov 23
The present invention provides improved P450-BM3 variants with improved activity.
Robert Osborne, Vesna Mitchell, Khin Yu Naing Htwe, Xiyun Zhang, Erika M. Milczek, Jeffrey C. Moore
Filed: 15 Feb 22
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Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
31 Oct 23
The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Oscar Alvizo, Melissa Ann Mayo, Jeffrey C. Moore
Filed: 6 May 22
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Recombinant Factor VIII Variants
26 Oct 23
The present disclosure provides recombinant factor VIII polypeptides, polynucleotides encoding the recombinant factor VIII polypeptides, and compositions thereof, wherein the recombinant factor VIII polypeptides have been engineered to provide improved expression, activity/potency, clotting activity/potency, serum/plasma stability, and/or reduced immunogenicity.
Jeremiah Dallas Heredia, Nikki D. Kruse, Aksiniya Lyubenova Petkova, Marcus Rohovie, Adam P. Silverman
Filed: 5 Jan 23
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Engineered phosphopentomutase variant enzymes
24 Oct 23
The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Scott J. Novick, Xiang Yi, Nikki Dellas, Oscar Alvizo, Jovana Nazor, Da Duan, Vesna Mitchell, Jonathan Vroom, Santhosh Sivaramakrishnan, Nandhitha Subramanian, Jeffrey C. Moore, Mark Huffman, Agustina Rodriguez-Granillo, Deeptak Verma, Grant S. Murphy, Nicholas Marshall, Jay Russell, Keith A. Canada
Filed: 10 May 21
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Engineered Biocatalysts and Methods for Synthesizing Chiral Amines
19 Oct 23
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
Weng Lin Tang, Helen Hsieh, Son Pham, Derek Smith, Steven J. Collier
Filed: 29 Jun 23
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Engineered transaminase polypeptides
17 Oct 23
The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions.
Scott J. Novick, Nikki Dellas
Filed: 6 Apr 21
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Biocatalysts and Methods for the Synthesis of Substituted Lactams
5 Oct 23
The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.
Fabien Louis Cabirol, Haibin Chen, Anupam Gohel, Paulina Elena Salim, Derek J. Smith, Jacob Janey, Birgit Kosjek, Weng Lin Tang, Helen Hsieh, Son Q. Pham
Filed: 3 Feb 23
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Engineered amylase variants
26 Sep 23
The present invention provides engineered amylase polypeptides and compositions thereof.
Chinping Chng, Nikki Dellas, Da Duan, Ravi David Garcia, Harvinder Chagger Maniar
Filed: 27 Aug 21
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Engineered Phenylalanine Ammonia Lyase Polypeptides
21 Sep 23
The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides.
Chinping Chng, William Casey Hallows, Nicholas J. Agard, Oscar Alvizo, Nikki Dellas, Gjalt W. Huisman, John Joseph Nicols
Filed: 13 Jan 23
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Engineered Imine Reductases and Methods for the Reductive Amination of Ketone and Amine Compounds
21 Sep 23
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
Haibin Chen, Steven J. Collier, Jovana Nazor, Joly Sukumaran, Derek Smith, Jeffrey C. Moore, Gregory Hughes, Jacob Janey, Gjalt W. Huisman, Scott J. Novick, Nicholas J. Agard, Oscar Alvizo, Gregory A. Cope, Wan Lin Yeo, Stefanie Ng Minor
Filed: 17 Feb 23
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Engineered Phenylalanine Ammonia Lyase Polypeptides
21 Sep 23
The present invention provides engineered phenylalanine ammonia lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia lyase (PAL) polypeptides.
Chinping Chng, William Casey Hallows, Nicholas J. Agard, Oscar Alvizo, Nikki Dellas, Gjalt W. Huisman, John Joseph Nicols
Filed: 13 Jan 23
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Engineered glycosyltransferases and steviol glycoside glucosylation methods
19 Sep 23
The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides.
Jonathan Vroom, Stephanie Sue Galanie, Jack Liang, Joyce Liu, Nikki Dellas, Melissa Ann Mayo, David Entwistle
Filed: 17 Jul 19