3 patents
Utility
Histamine Dihydrochloride Combinations and Uses Thereof
23 Sep 21
The present invention provides methods of treating cancer in a subject, preventing or delaying relapse to a cancer in a subject in remission, prolonging remission from cancer, increasing survival, and decreasing or alleviating cancer symptoms comprising a) administering histamine dihydrochloride and an inhibitor of the Programmed cell Death protein 1 (PD-1)/Programmed Death Ligand 1 (PD-L1) or b) administering an agent that decreases reactive oxygen species (ROS) optionally, together with a histamine receptor agonist.
Anna MARTNER, Frida EWALD SANDER, Fredrik BERGH THOREN, Kristoffer HELLSTRAND, Hanna WIKTORIN GRAUERS
Filed: 8 Feb 17
Utility
Methods and Compositions for Treating and Preventing Metastatic Tumors
23 Dec 20
Some embodiments of the methods and compositions provided herein relate to the treatment and amelioration of metastatic tumors and to the prevention of distant metastasis.
Anna Martner, Kristoffer Hellstrand
Filed: 26 Jan 20
Utility
Methods of Delaying and Preventing Acute Myeloid Leukemia Relapse
15 Jul 20
Disclosed herein include methods of delaying and preventing acute myeloid leukemia (AML) relapse in patients with mutant nucleophosmin 1 (NPM1) by co-administration of histamine, or derivatives thereof, and interleukin-2 (IL-2).
Anna Martner, Fredrik Bergh Thorén, Johan Aurelius, Kristoffer Hellstrand
Filed: 27 Jun 18
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