481 patents
Utility
Compositions and Methods for Molecular Labeling
11 Jan 24
The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct.
Michael Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
Filed: 26 Jul 23
Utility
Sample Reader with Oil Recirculation
11 Jan 24
Systems, including methods and apparatus, for analyzing partitioned samples, such as droplets, using recirculated fluid.
Steve HOBBS, Darren R. LINK, Stuart YOUNG, Andrew WALGRAVE, Carolyn REIFSNYDER, Jonathan C. FEARNOW, Douglas GREINER, Chris GERGLEY
Filed: 5 Jul 23
Utility
System and method for leakage control in a particle capture system
9 Jan 24
A system and method for target material capture, the method comprising: receiving a set of target cells into an array of wells defined at a surface plane of a substrate; receiving a set of particles into the array of wells, thereby co-capturing the set of target cells and the set of particles; achieving a desired state for the array of wells upon receiving a washing fluid into a cavity in communication with the array of wells; receiving a lysis buffer into the cavity; receiving a partitioning fluid into the cavity, thereby displacing the lysis buffer from the cavity and partitioning each of the array of wells from adjacent wells, at the surface plane; and retaining intercellular material of the set of target cells, individually with the set of particles within the array of wells.
Kalyan Handique, John Stark, Yadwinder Deol, Vishal Sharma
Filed: 21 Oct 22
Utility
System and method for isolating and analyzing cells
9 Jan 24
A system and method, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity and a fluid delivery module including a fluid pathway through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: generating a set of genetic complexes within individual wells of the array of wells.
Kalyan Handique, Vishal Sharma, Priyadarshini Gogoi, William Chow, Austin Payne, Kyle Gleason, Brian Boniface, John Connolly, Sam Tuck
Filed: 13 Oct 22
Utility
Emulsion chemistry for encapsulated droplets
9 Jan 24
System, including methods, apparatus, compositions, and kits, for making and using a stabilized emulsion.
Amy L. Hiddessen, Benjamin J. Hindson
Filed: 11 Jun 21
Utility
Mixed Mode Cation Exchange Chromatography Ligands Based on 1,3-DIOXOISOINDOLIN-2-YL Structures
4 Jan 24
The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
CHRISTOPHER BELISLE, JIALI LIAO, EDWIN LOZANO
Filed: 28 Jul 23
Utility
Digital Analyte Analysis
4 Jan 24
The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same.
Jonathan William Larson, Qun Zhong, Darren Roy Link
Filed: 12 Sep 23
Utility
Microfluidic system and method for arranging objects
2 Jan 24
Microfluidic methods of altering the spacing of a stream of objects.
Lung-Hsin Hung, Robert Meltzer, Lucas Frenz
Filed: 24 Jun 21
Utility
Method and system for thermally controlling a chemical reaction in droplets
2 Jan 24
Methods and systems for thermally controlling a chemical reaction in droplets.
Darren R. Link
Filed: 24 Mar 21
Utility
Use of Homologous Recombinase to Improve Efficiency and Sensitivity of Single Cell Assays
28 Dec 23
Methods of decreasing bead aggregation and improving specificity of nucleic acid hybridization using non-specific nucleic acid binding proteins is described.
Rahul RATTAN, Marta GONZALEZ-PLASKY
Filed: 13 Jun 23
Utility
Digital Protein Quantification
28 Dec 23
Methods and compositions are described for single cell resolution, quantitative proteomic analysis using high throughput sequencing.
Jeremy Agresti, Ronald Lebofsky
Filed: 18 Jul 23
Utility
System and Method for Leakage Control In a Particle Capture System
21 Dec 23
A system and method for target material capture, the method comprising: receiving a set of target cells into an array of wells defined at a surface plane of a substrate; receiving a set of particles into the array of wells, thereby co-capturing the set of target cells and the set of particles; achieving a desired state for the array of wells upon receiving a washing fluid into a cavity in communication with the array of wells; receiving a lysis buffer into the cavity; receiving a partitioning fluid into the cavity, thereby displacing the lysis buffer from the cavity and partitioning each of the array of wells from adjacent wells, at the surface plane; and retaining intercellular material of the set of target cells, individually with the set of particles within the array of wells.
Kalyan Handique, John Stark, Yadwinder Deol, Vishal Sharma
Filed: 6 Sep 23
Utility
Sandwich Assays In Droplets
21 Dec 23
The invention generally relates to performing sandwich assays in droplets.
Michael L. Samuels, Darren Roy Link
Filed: 18 Jul 23
Utility
Emulsion compositions and methods of their use
19 Dec 23
Emulsion compositions are provided herein.
Yi Xue, Joshua Ritchey, Robert Meltzer
Filed: 4 Feb 22
Utility
Chromatography plug
12 Dec 23
Chromatography column components are described.
Pascal Wijnant, John Tipton, Christopher Ward
Filed: 17 Nov 17
Utility
Dynamic axial compression for preparative columns using external compression
12 Dec 23
A dynamic axial compression column is disclosed herein.
Christopher Belisle, Mark A. Snyder
Filed: 15 Mar 22
Utility
Multiple Beads Per Droplet Resolution
7 Dec 23
Methods of generating a nucleic acid signature for identifying particles associated in a partition are provided.
Ronald LEBOFSKY, Nicholas HEREDIA
Filed: 11 Aug 23
Utility
Method and System for Detecting Reverse Transcriptase Activity by Digital Assay
7 Dec 23
Method and system for detecting reverse transcriptase activity of a sample by digital assay.
Congcong MA, Duc DO, Douglas GREINER
Filed: 26 May 23
Utility
Droplet Tagging Contiguity Preserved Tagmented Dna
7 Dec 23
Methods and compositions for maintaining DNA contiguity for sequencing is provided.
Ronald LEBOFSKY, Jeremy AGRESTI
Filed: 4 May 23
Utility
Enzyme Quantification
7 Dec 23
The invention generally relates to methods for quantifying an amount of enzyme molecules.
Darren Roy Link, Michael L. Samuels
Filed: 11 Aug 23