232 patents
Utility
Compositions and Methods for Molecular Labeling
11 Jan 24
The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct.
Michael Samuels, Jeffrey Charles Olson, Andrew Watson, Keith Brown, Darren R. Link
Filed: 26 Jul 23
Utility
Sample Reader with Oil Recirculation
11 Jan 24
Systems, including methods and apparatus, for analyzing partitioned samples, such as droplets, using recirculated fluid.
Steve HOBBS, Darren R. LINK, Stuart YOUNG, Andrew WALGRAVE, Carolyn REIFSNYDER, Jonathan C. FEARNOW, Douglas GREINER, Chris GERGLEY
Filed: 5 Jul 23
Utility
Mixed Mode Cation Exchange Chromatography Ligands Based on 1,3-DIOXOISOINDOLIN-2-YL Structures
4 Jan 24
The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-dioxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
CHRISTOPHER BELISLE, JIALI LIAO, EDWIN LOZANO
Filed: 28 Jul 23
Utility
Digital Analyte Analysis
4 Jan 24
The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same.
Jonathan William Larson, Qun Zhong, Darren Roy Link
Filed: 12 Sep 23
Utility
Digital Protein Quantification
28 Dec 23
Methods and compositions are described for single cell resolution, quantitative proteomic analysis using high throughput sequencing.
Jeremy Agresti, Ronald Lebofsky
Filed: 18 Jul 23
Utility
Use of Homologous Recombinase to Improve Efficiency and Sensitivity of Single Cell Assays
28 Dec 23
Methods of decreasing bead aggregation and improving specificity of nucleic acid hybridization using non-specific nucleic acid binding proteins is described.
Rahul RATTAN, Marta GONZALEZ-PLASKY
Filed: 13 Jun 23
Utility
Sandwich Assays In Droplets
21 Dec 23
The invention generally relates to performing sandwich assays in droplets.
Michael L. Samuels, Darren Roy Link
Filed: 18 Jul 23
Utility
System and Method for Leakage Control In a Particle Capture System
21 Dec 23
A system and method for target material capture, the method comprising: receiving a set of target cells into an array of wells defined at a surface plane of a substrate; receiving a set of particles into the array of wells, thereby co-capturing the set of target cells and the set of particles; achieving a desired state for the array of wells upon receiving a washing fluid into a cavity in communication with the array of wells; receiving a lysis buffer into the cavity; receiving a partitioning fluid into the cavity, thereby displacing the lysis buffer from the cavity and partitioning each of the array of wells from adjacent wells, at the surface plane; and retaining intercellular material of the set of target cells, individually with the set of particles within the array of wells.
Kalyan Handique, John Stark, Yadwinder Deol, Vishal Sharma
Filed: 6 Sep 23
Utility
Method and System for Detecting Reverse Transcriptase Activity by Digital Assay
7 Dec 23
Method and system for detecting reverse transcriptase activity of a sample by digital assay.
Congcong MA, Duc DO, Douglas GREINER
Filed: 26 May 23
Utility
Multiple Beads Per Droplet Resolution
7 Dec 23
Methods of generating a nucleic acid signature for identifying particles associated in a partition are provided.
Ronald LEBOFSKY, Nicholas HEREDIA
Filed: 11 Aug 23
Utility
Droplet Tagging Contiguity Preserved Tagmented Dna
7 Dec 23
Methods and compositions for maintaining DNA contiguity for sequencing is provided.
Ronald LEBOFSKY, Jeremy AGRESTI
Filed: 4 May 23
Utility
Enzyme Quantification
7 Dec 23
The invention generally relates to methods for quantifying an amount of enzyme molecules.
Darren Roy Link, Michael L. Samuels
Filed: 11 Aug 23
Utility
Methods and Hydrogel Compositions for Partitioning Biological Samples
30 Nov 23
Methods of making and forming partitions in nanovials are provided.
Ronald LEBOFSKY, Josh SHINOFF, Adam M. McCOY, Man CHENG
Filed: 30 May 23
Utility
Microfluidic Devices and Processes
23 Nov 23
A method comprises providing a microfluidic device including a reservoir; an injection nozzle at the bottom of the reservoir, the injection nozzle being wider at its top than at its bottom; an injection channel below the injection nozzle; and a microfluidic channel below the injection channel.
Lorenzo Franco Teodoro Petrini, Iago Pereiro Pereiro, Robert Dean Lovchik, Anna Fomitcheva Khartchenko, Anel Zulji, Govind Kaigala, Cristina Boero, Olivier Michel Christian Noël, Christophe Guex, Stéphane Guillod, Aurélie Bolon
Filed: 27 Jul 23
Utility
Partition-based Method of Analysis
23 Nov 23
Methods of partition-based analysis.
Amy L. Hiddessen, Donald A. Masquelier, Kevin D. Ness, Benjamin J. Hindson, Anthony J. Makarewicz, Erin R. Chia, Billy W. Colston, Serge Saxonov, Svilen S. Tzonev, Michael Y. Lucero, Ryan T. Koehler
Filed: 31 Jul 23
Utility
Method and System for Sampling Material from Cells
16 Nov 23
Methods, systems, and devices for sampling/isolating material from cells.
Arkadiusz BIBILLO, Pranav PATEL, Christopher REGGIARDO, Jonathan Petersen
Filed: 2 Jan 23
Utility
Microfluidic Probes
16 Nov 23
In one implementation, a microfluidic probe has a non-planar processing surface and an inlet aperture.
Iago Pereiro Pereiro, Anna Fomitcheva Khartchenko, Robert Dean Lovchik, Govind Kaigala, Lorenzo Franco Teodoro Petrini, Anel Zulji, Frédéric M. Buffière, Johann Guégan, Eliane Rivalin, Sylvie Villard-Saussine
Filed: 27 Jul 23
Utility
Method and System for Detection of Particles Focused Asymmetrically
16 Nov 23
Methods and systems for detecting particles.
Ahmadreza RASHEDI
Filed: 15 May 23
Utility
Apparatus for Automatic Handling of a Sample
16 Nov 23
An apparatus for automatic handling of a sample within a receptacle, the apparatus having an axis A-A and comprising a carousel being configured to rotate about the axis A-A, a support extending above the carousel, the support including a carrier configured to move along X, Z coordinate axes to transport receptacles from a first location to a second location, wherein, the X coordinate axis is parallel to the axis A-A, the Z coordinate axis is perpendicular to the axis A-A and to the X coordinate axis, and the X and Z coordinate axes define a line of operation, wherein, the apparatus is configured so that rotation of the carousel aligns a receptacle with the line of operation of the carrier to allow the carrier to transport the receptacle from the first location to the second location.
Sébastien BERNAY, Thomas BARNAY, Anaïs FAURE-VIDAL
Filed: 15 Sep 21
Utility
High Sensitivity Immunoassay
2 Nov 23
The disclosure provides a highly sensitive assay to detect the presence of a target analyte in a sample.
William STRONG, Eli HEFNER, Carl MARLOWE
Filed: 26 Apr 23