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Oncternal Therapeutics (ONCT)

Utility
Uses of indolinone compounds
29 Mar 22
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.
Brian Lannutti, Katayoun Jessen, James Bradley Breitmeyer
Filed: 13 Apr 20
Utility
Compounds for Treatment of Cancer
27 Jan 22
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Wei LI, Min XIAO, James DALTON, Sunjoo AHN, Duane D. MILLER, Jin WANG
Filed: 8 Jul 21
Utility
Compounds for treatment of cancer
10 Aug 21
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Wei Li, Min Xiao, James Dalton, Sunjoo Ahn, Duane D Miller, Jin Wang
Filed: 21 Feb 19
Utility
Selective Androgen Receptor Degrader (Sard) Ligands and Methods of Use Thereof
28 Jan 21
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Ramesh NARAYANAN, Duane D. MILLER, Thamarai PONNUSAMY, Dong-Jin HWANG, Charles B. DUKE, Christopher C. COSS, Amanda JONES, James T. DALTON
Filed: 29 Jan 20
Utility
Compounds for treatment of cancer
14 Dec 20
The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.
Duane D. Miller, Jianjun Chen, James T. Dalton, Chien-Ming Li, Sunjoo Ahn, Wei Li
Filed: 15 Jan 18
Utility
Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy
30 Nov 20
This invention relates to the treatment of breast cancer in a subject, for example a female subject.
Mitchell S. Steiner, Ramesh Narayanan, Sunjoo Ahn, James T. Dalton
Filed: 7 Jan 19
Utility
Uses of Indolinone Compounds
12 Aug 20
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.
Brian Lannutti, Katayoun Jessen, James Bradley Breitmeyer
Filed: 12 Apr 20
Utility
Selective Androgen Receptor Degrader (Sard) Ligands and Methods of Use Thereof
15 Jul 20
This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Ramesh NARAYANAN, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Yali He, Jayaprakash Pagadala, Christopher C. Coss, James T. Dalton, Charles B. Duke
Filed: 29 Aug 19
Utility
Indoline analogs and uses thereof
13 Jul 20
Indoline derivative compounds that act as EWS-FLI1 transcription factor inhibitors are provided.
Stephen E. Webber
Filed: 2 Jun 19
Utility
Uses of indolinone compounds
11 May 20
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.
Brian Lannutti, Katayoun Jessen, James Bradley Breitmeyer
Filed: 26 Aug 18
Utility
Selective androgen receptor degrader (SARD) ligands and methods of use thereof
23 Mar 20
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Charles B. Duke, Christopher C. Coss, Amanda Jones, James T. Dalton
Filed: 4 Oct 18
Utility
Indoline Analogs and Uses Thereof
6 Nov 19
Indoline derivative compounds that act as EWS-FLI1 transcription factor inhibitors are provided.
Stephen E. Webber
Filed: 2 Jun 19
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