8 patents
Utility
Compounds for treatment of cancer
11 Oct 22
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Wei Li, Min Xiao, James Dalton, Sunjoo Ahn, Duane D Miller, Jin Wang
Filed: 20 Sep 16
Utility
Uses of indolinone compounds
29 Mar 22
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.
Brian Lannutti, Katayoun Jessen, James Bradley Breitmeyer
Filed: 13 Apr 20
Utility
Compounds for treatment of cancer
10 Aug 21
The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
Wei Li, Min Xiao, James Dalton, Sunjoo Ahn, Duane D Miller, Jin Wang
Filed: 21 Feb 19
Utility
Compounds for treatment of cancer
14 Dec 20
The present invention relates to a compound of formula XXII and a compound of formula 17ya, which are defined as anywhere in the specification, to a composition comprising the same, and to a method of using thereof in the treatment of various forms of cancer.
Duane D. Miller, Jianjun Chen, James T. Dalton, Chien-Ming Li, Sunjoo Ahn, Wei Li
Filed: 15 Jan 18
Utility
Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy
30 Nov 20
This invention relates to the treatment of breast cancer in a subject, for example a female subject.
Mitchell S. Steiner, Ramesh Narayanan, Sunjoo Ahn, James T. Dalton
Filed: 7 Jan 19
Utility
Indoline analogs and uses thereof
13 Jul 20
Indoline derivative compounds that act as EWS-FLI1 transcription factor inhibitors are provided.
Stephen E. Webber
Filed: 2 Jun 19
Utility
Uses of indolinone compounds
11 May 20
Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.
Brian Lannutti, Katayoun Jessen, James Bradley Breitmeyer
Filed: 26 Aug 18
Utility
Selective androgen receptor degrader (SARD) ligands and methods of use thereof
23 Mar 20
This invention provides novel 3-amino propanamide selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other 5 hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Ramesh Narayanan, Duane D. Miller, Thamarai Ponnusamy, Dong-Jin Hwang, Charles B. Duke, Christopher C. Coss, Amanda Jones, James T. Dalton
Filed: 4 Oct 18
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