14 patents
Utility
Intravenous Ganaxolone Formulations and Methods of Use in Treating Status Epilepticus and Other Seizure Disorders
18 Jan 24
The disclosure provides an injectable ganaxolone formulation comprising ganaxolone, sulfobutyl ether-β-cyclodextrin; and water.
Mingbao ZHANG, Raymond C. GLOWAKY
Filed: 21 Sep 23
Utility
Ganaxolone for Use In Treatment of Status Epilepticus
21 Dec 23
This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid.
David CZEKAI, Maciej GASIOR, Lorianne MASUOKA, Julia TSAI, Joseph HULIHAN, Alex AIMETTI
Filed: 28 Aug 23
Utility
Amorphous Solid Dispersion Ganaxolone Formulation
7 Dec 23
This disclosure relates to a solid pharmaceutical formulation comprising an amorphous neurosteroid dispersed in a polymer matrix that is suitable for oral administration.
David CZEKAI, Vinod TULIANI, Michael SAPORITO
Filed: 20 Jul 23
Utility
Ganaxolone for Use In Treatment of Super Refractory Status Epilepticus
16 Nov 23
This invention relates to methods for treating super refractory status epilepticus by rapidly weaning the subject in need thereof off an anesthetic agent prior to initiation of administering to the subject in need thereof of ganaxolone at a high infusion dose.
Henrikas VAITKEVICIUS, Maciej GASIOR, Joseph HULIHAN
Filed: 22 May 23
Utility
Use of Ganaxolone In Treating an Epilepsy Disorder
12 Oct 23
The disclosure to methods for treating seizure or an epilepsy disorder comprising administering to a subject in need thereof a therapeutically effective amount of ganaxolone or a pharmaceutically acceptable salt thereof.
Alex Aimetti, Joseph HULIHAN
Filed: 5 Jun 23
Utility
Intravenous Ganaxolone Formulations and Methods of Use In Treating Status Epilepticus and Other Seizure Disorders
21 Sep 23
The disclosure provides an injectable ganaxolone formulation comprising ganaxolone, sulfobutyl ether-β-cyclodextrin; and water.
Mingbao ZHANG, Raymond C. Glowaky
Filed: 28 Mar 23
Utility
Ganaxolone for Use In Treatment of Status Epilepticus
25 Aug 22
This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid.
David CZEKAI, Maciej GASIOR, Lorianne MASUOKA, Julia TSAI, Joseph HULIHAN, Alex AIMETTI
Filed: 26 Apr 22
Utility
Ganaxolone for Use In Treating Genetic Epileptic Disorders
11 Aug 22
The disclosure provides a method of treating a mammal having a genetic epileptic disorder, comprising chronically administering a pharmaceutically acceptable pregnenolone neurosteroid to a mammal having a genetic epileptic disorder in an amount effective to reduce the seizure frequency in the mammal.
Lorianne K. Masuoka, Jaakko Lappalainen
Filed: 24 Mar 22
Utility
Ganaxolone for Use In Treatment of Status Epilepticus
30 Jun 22
This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid.
David CZEKAI, Maciej GASIOR, Lorianne MASUOKA, Julia TSAI, Joseph HULIHAN, Alex AIMETTI
Filed: 4 Aug 21
Utility
Ganaxolone for Use In Treatment of Status Epilepticus
24 Jun 21
This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid.
David CZEKAI, Maciej GASIOR, Lorianne MASUOKA, Julia TSAI, Joseph HULIHAN, Alex AIMETTI
Filed: 26 Feb 21
Utility
Injectable Neurosteroid Formulations Containing Nanoparticles
6 May 21
Mingbao Zhang, Raymond C. Glowaky, David Czekai
Filed: 13 Aug 20
Utility
Methods of Treating Certain Depressive Disorders and Delirium Tremens
16 Sep 20
The disclosure provides a method of treating a patient having postpartum depression, premenstrual dysphoric disorder, menopausal depression, or delirium tremens comprising administering an effective amount of an injectable neurosteroid formulation to the patient.
Christopher Cashman, Jaakko Lappalainen, David A. Czekai
Filed: 24 Mar 20
Utility
Ganaxolone for Use In Prophylaxis and Treatment of Pospartum Depression
10 Jun 20
Uses of ganaxolone in prophylaxis and treatment of postpartum depression are described.
Alex Aimetti, Christopher Cashman, Lorianne Masuoka, Jaakko Lappalainen
Filed: 5 Dec 19
Utility
Method of Administering a Neurosteroid to Effect Electroencephalographic (Eeg) Burst Suppression
23 Oct 19
The disclosure provides a method of eliciting electroencephalographic burst suppression or electroencephalographic suppression in a patient. the method includes administering to the patient a formulation comprising neurosteroid nanoparticles having a D50 of less than 2 microns and a polymeric surface stabilizer chosen from hydroxyethyl starch, dextran, and povidone and 0.1 to 50 mg of the neurosteroid per 1 kg of the patient's body weight The neurosteroid may be administered intravenously, intramuscularly, subcutaneously, or orally.
Michael SAPORITO, Albena PATRONEVA, David CZEKAI
Filed: 12 Oct 17
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