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Humanigen (HGEN)

Utility
Materials and Methods for Treating Cancer
10 Feb 22
This document provides methods and materials involved in treating cancer.
Cameron DURRANT, Dale CHAPPELL, Saad J. KENDERIAN, Rosalie M. STERNER, Michelle J. COX, Reona SAKEMURA
Filed: 31 Oct 19
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
27 Jan 22
Methods for reducing blood-brain barrier disruption in a subject treated with immunotherapy, the method comprising administering a recombinant GM-CSF antagonist to the subject.
Cameron DURRANT, Dale CHAPPELL
Filed: 16 Jul 21
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
21 Oct 21
Methods for neutralizing and/or removing human GM-CSF in a subject in need thereof, comprising administering to the subject CAR-T cells having a GM-CSF gene knockout (GM-CSFk/o CAR-T cells) are provided.
Cameron Durrant, Dale Chappell
Filed: 19 Apr 21
Utility
Methods for Treating Coronavirus Infection and Resulting Inflammation-induced Lung Injury
7 Oct 21
The present invention provides methods for treating a subject infected with 2019 coronavirus (SARS-CoV-2) comprising administering to the subject a therapeutically effective amount of a GM-CSF antagonist or a therapeutically effective amount of a GM-CSF antagonist and a second drug, including an anti-viral agent, an anti-SARS-CoV-2 vaccine, and serum containing human polyclonal antibodies to SARS-CoV-2.
Cameron DURRANT, Dale CHAPPELL
Filed: 29 Mar 21
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
23 Sep 21
Methods for neutralizing and/or removing human GM-CSF in a subject in need thereof, comprising administering to the subject CAR-T cells having a GM-CSF gene knockout (GM-CSFk/o CAR-T cells) are provided.
Cameron DURRANT, Dale CHAPPELL
Filed: 10 Sep 19
Utility
Materials and Methods for Treating Cancer
16 Sep 21
This document provides methods and materials involved in treating cancer.
Cameron DURRANT, Dale CHAPPELL, Saad J. KENDERIAN, Michelle J. COX, Reona SAKEMURA
Filed: 22 Mar 21
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
2 Sep 21
Methods for reducing relapse rate or preventing occurrence of tumor relapse in a subject treated with immunotherapy, in an absence of an incidence of immunotherapy-related toxicity or in a presence of immunotherapy-related toxicity.
Cameron DURRANT, Dale Chappell
Filed: 16 Jan 21
Utility
EPHA3 Directed Car-t Cells for Treatment of Tumors
12 Aug 21
This invention provides chimeric antigen receptors (CARs) targeting human EphA3 and dual targeting CARs that bind to human EphA3 and to human mutant epidermal growth factor receptor variant III (EGFRvIII).
Cameron DURRANT, Dale CHAPPELL, Saad J. KENDERIAN
Filed: 9 Nov 20
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
29 Jul 21
Methods for reducing relapse rate or preventing occurrence of tumor relapse in a subject treated with immunotherapy, in an absence of an incidence of immunotherapy-related toxicity or in a presence of immunotherapy-related toxicity.
Cameron DURRANT, Dale CHAPPELL
Filed: 27 Jan 21
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
6 May 21
Methods of inhibiting or reducing the incidence or the severity of immunotherapy-related toxicity in a subject, the method comprising a step of administering a recombinant hGM-CSF antagonist to the subject, wherein said administering inhibits or reduces the incidence or the severity of immunotherapy-related toxicity in said subject, are provided.
Cameron DURRANT, Dale CHAPPELL
Filed: 13 Nov 20
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
11 Nov 20
Methods of inhibiting or reducing the incidence or the severity of immunotherapy-related toxicity in a subject, the method comprising a step of administering a recombinant hGMCSF antagonist to the subject, wherein said administering inhibits or reduces the incidence or the severity of immunotherapy-related toxicity in said subject, are provided.
Cameron DURRANT, Dale CHAPPELL
Filed: 1 Oct 18
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
6 Nov 19
Methods for reducing relapse rate or preventing occurrence of tumor relapse in a subject treated with immunotherapy, in an absence of an incidence of immunotherapy-related toxicity or in a presence of immunotherapy-related toxicity.
Cameron DURRANT, Dale Chappell
Filed: 14 Jan 19
Utility
Methods of Treating Immunotherapy-related Toxicity Using a GM-CSF Antagonist
23 Oct 19
Methods for reducing blood-brain barrier disruption in a subject treated with immunotherapy, the method comprising administering a recombinant GM-CSF antagonist to the subject.
Cameron Durrant, Dale CHAPPELL
Filed: 21 Feb 19
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