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Humanigen (HGEN)

Utility
Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist
28 Sep 21
Methods for reducing blood-brain barrier disruption in a subject treated with immunotherapy, the method comprising administering a recombinant GM-CSF antagonist to the subject.
Cameron Durrant, Dale Chappell
Filed: 22 Feb 19
Utility
Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab
23 Feb 21
Methods for reducing relapse rate or preventing occurrence of tumor relapse in a subject treated with immunotherapy, in an absence of an incidence of immunotherapy-related toxicity or in a presence of immunotherapy-related toxicity.
Cameron Durrant, Dale Chappell
Filed: 15 Jan 19
Utility
Immunoglobulin variable region cassette exchange
16 Feb 21
The invention provides methods for generating human antibodies with the specificity of a reference antibody by replacement of portions of the VH and VL sequences of the reference antibody with sequences from human antibody repertoires.
Christopher Robert Bebbington, Kenneth R. Luehrsen, Geoffrey T. Yarranton
Filed: 14 Dec 15
Utility
Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity
26 Jan 21
Methods for reducing relapse rate or preventing occurrence of tumor relapse in a subject treated with immunotherapy, in an absence of an incidence of immunotherapy-related toxicity or in a presence of immunotherapy-related toxicity.
Cameron Durrant, Dale Chappell
Filed: 29 Nov 18
Utility
Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist
21 Dec 20
Methods of inhibiting or reducing the incidence or the severity of immunotherapy-related toxicity in a subject, the method comprising a step of administering a recombinant hGM-CSF antagonist to the subject, wherein said administering inhibits or reduces the incidence or the severity of immunotherapy-related toxicity in said subject, are provided.
Cameron Durrant, Dale Chappell
Filed: 1 Oct 18
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