71 patents
Page 3 of 4
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MND promoter chimeric antigen receptors
14 Sep 20
Vector compositions comprising a myeloproliferative sarcoma virus enhancer, negative control region deleted, dl587rev primer-binding site substituted (MND) promoter operably linked to a chimeric antigen receptor (CAR) are provided.
Richard Morgan, Kevin Friedman, Byoung Ryu
Filed: 23 Apr 15
Utility
Anti-bcma Car T Cell Compositions
19 Aug 20
The invention provides improved anti-BCMA CAR T cell compositions for adoptive T cell therapy for relapsed/refractory multiple myeloma.
Travis QUIGLEY, Robert ROSS
Filed: 2 Nov 17
Utility
BCMA chimeric antigen receptors
11 May 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 7 Jul 19
Utility
BCMA chimeric antigen receptors
4 May 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 2 Jul 19
Utility
BCMA chimeric antigen receptors
4 May 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 7 Jul 19
Utility
Therapeutic retroviral vectors for gene therapy
27 Apr 20
The invention provides improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells.
Philippe Louis Leboulch, Robert Pawliuk, Karen Westerman
Filed: 12 Sep 18
Utility
TGFBetaR2 ENDONUCLEASE VARIANTS, COMPOSITIONS, AND METHODS OF USE
22 Apr 20
The present disclosure provides improved genome editing compositions and methods for editing a TGFβR2 gene.
Jordan JARJOUR, Kyle HAVENS
Filed: 16 Oct 17
Utility
BCMA chimeric antigen receptors
20 Apr 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 2 Jul 19
Utility
Methods of Making T Cell Compositions
8 Apr 20
The invention provides improved T cell compositions and methods for manufacturing T cells.
Kevin Friedman
Filed: 8 Oct 19
Utility
CBLB Endonuclease Variants, Compositions, and Methods of Use
8 Apr 20
The present disclosure provides improved genome editing compositions and methods for editing a CBLB gene.
Jordan JARJOUR, Kyle HAVENS, Anne-Rachel KROSTAG
Filed: 24 Nov 19
Utility
Vectors and Compositions for Treating Hemoglobinopathies
8 Apr 20
The invention provides improved gene therapy vectors, compositions, and methods.
Gabor VERES, David A. WILLIAMS
Filed: 28 Mar 18
Utility
CBLB Endonuclease Variants, Compositions, and Methods of Use
18 Mar 20
The present disclosure provides improved genome editing compositions and methods for editing a CBLB gene.
Jordan JARJOUR, Kyle HAVENS, Anne-Rachel KROSTAG
Filed: 24 Nov 19
Utility
Bcma Chimeric Antigen Receptors
11 Mar 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard MORGAN, Kevin Friedman
Filed: 17 Jul 19
Utility
Multipartite Signaling Proteins and Uses Thereof
4 Mar 20
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
Jordan Jarjour, Alexander Astrakhan, Michael Certo
Filed: 13 Aug 19
Utility
Multipartite Signaling Proteins and Uses Thereof
4 Mar 20
The present disclosure relates to compositions and methods for using cells having chemically-induced fusion protein complexes to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
Jordan JARJOUR, Alexander ASTRAKHAN, Michael CERTO
Filed: 16 Sep 19
Utility
Gene Therapy for Mucopolysaccharidosis, Type II
4 Mar 20
The invention provides compositions and methods for treating Hunter Syndrome.
Kendrick A. GOSS, Geoffrey B. PARSONS
Filed: 5 Dec 17
Utility
BCMA chimeric antigen receptors
2 Mar 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 2 Jul 19
Utility
BCMA chimeric antigen receptors
2 Mar 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 2 Jul 19
Utility
Compounds for Improved Viral Transduction
12 Feb 20
The present invention provides methods and compositions for improving efficacy of viral transduction of cells.
Garrett Collins Heffner, Abraham Isaac Bassan
Filed: 27 Oct 19
Utility
Donor Repair Templates Multiplex Genome Editing
25 Dec 19
The present disclosure provides improved multiplex genome editing compositions and methods.
Baeckseung LEE, Alexander ASTRAKHAN
Filed: 14 Feb 18