21 patents
Utility
Compounds for improved viral transduction
5 Dec 23
The present invention provides methods and compositions for improving efficacy of viral transduction of cells.
Garrett Collins Heffner, Abraham Isaac Bassan
Filed: 17 Dec 20
Utility
Therapeutic retroviral vectors for gene therapy
18 Jul 23
Provided are improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells.
Philippe Louis Leboulch, Robert Pawliuk, Karen Westerman
Filed: 16 Mar 20
Utility
Sickled beta globin antibodies
27 Dec 22
The invention generally provides improved anti-sickled-globin antibodies and fragments thereof.
Olivier Negre
Filed: 14 Dec 18
Utility
VCN enhancer compositions and methods of using the same
10 May 22
The invention provides improved gene therapy methods and compositions.
Melissa Bonner, Olivier Negre, Christopher Tipper
Filed: 10 Feb 17
Utility
Vectors and compositions for treating hemoglobinopathies
1 Mar 22
The invention provides improved gene therapy vectors, compositions, and methods.
Gabor Veres, David A. Williams
Filed: 29 Mar 18
Utility
BCMA chimeric antigen receptors
1 Jun 21
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 23 Oct 20
Utility
CBLB endonuclease variants, compositions, and methods of use
23 Feb 21
The present disclosure provides improved genome editing compositions and methods for editing a CBLB gene.
Jordan Jarjour, Kyle Havens, Anne-Rachel Krostag
Filed: 25 Nov 19
Utility
Compounds for improved viral transduction
2 Feb 21
The present invention provides methods and compositions for improving efficacy of viral transduction of cells.
Garrett Collins Heffner, Abraham Isaac Bassan
Filed: 28 Oct 19
Utility
CBLB endonuclease variants, compositions, and methods of use
5 Oct 20
The present disclosure provides improved genome editing compositions and methods for editing a CBLB gene.
Jordan Jarjour, Kyle Havens, Anne-Rachel Krostag
Filed: 24 Nov 19
Utility
MND promoter chimeric antigen receptors
14 Sep 20
Vector compositions comprising a myeloproliferative sarcoma virus enhancer, negative control region deleted, dl587rev primer-binding site substituted (MND) promoter operably linked to a chimeric antigen receptor (CAR) are provided.
Richard Morgan, Kevin Friedman, Byoung Ryu
Filed: 23 Apr 15
Utility
BCMA chimeric antigen receptors
11 May 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 7 Jul 19
Utility
BCMA chimeric antigen receptors
4 May 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 2 Jul 19
Utility
BCMA chimeric antigen receptors
4 May 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 7 Jul 19
Utility
Therapeutic retroviral vectors for gene therapy
27 Apr 20
The invention provides improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells.
Philippe Louis Leboulch, Robert Pawliuk, Karen Westerman
Filed: 12 Sep 18
Utility
BCMA chimeric antigen receptors
20 Apr 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 2 Jul 19
Utility
BCMA chimeric antigen receptors
2 Mar 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 2 Jul 19
Utility
BCMA chimeric antigen receptors
2 Mar 20
The invention provides improved compositions for adoptive T cell therapies for B cell related conditions.
Richard Morgan, Kevin Friedman
Filed: 2 Jul 19
Utility
Compounds for improved viral transduction
9 Dec 19
The present invention provides methods and compositions for improving the efficacy of viral transduction of cells.
Garrett Collins Heffner, Abraham Isaac Bassan
Filed: 3 Jun 18
Utility
Methods of making T cell compositions
18 Nov 19
The invention provides improved T cell compositions and methods for manufacturing T cells.
Kevin Friedman
Filed: 4 Jun 15
Utility
Multipartite signaling proteins and uses thereof
28 Oct 19
Nucleic acids that encode chemically-inducible fusion proteins, vectors that contain nucleic acids that encode chemically-inducible fusion proteins, chemically-inducible fusion proteins, chemically-inducible fusion protein complexes, and non-natural cells that are modified to express chemically-inducible fusion proteins to spatially and temporally control immune cell signal initiation and downstream responses for treating disease.
Jordan Jarjour, Alexander Astrakhan, Michael Certo
Filed: 12 Dec 18