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Pacific Biosciences of California (PACB)

Utility
Methods and compositions for delivery of molecules and complexes to reaction sites
17 May 22
The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites.
Jaime Juan Benitez-Marzan, Natasha Popovich, Lei Sun
Filed: 28 Jun 19
Utility
Reversible Modification of Nucleotides
12 May 22
Denis Malyshev, Aaron W. Feldman
Filed: 17 Sep 21
Utility
Methods of quantifying target nucleic acids and identifying sequence variants
10 May 22
The present disclosure provides compositions, methods and systems for quantifying target sequences and identifying target sequence variants.
Yi Zhang, Steven Brentano, Eugene Tu, Kandaswamy Vijayan
Filed: 6 Apr 17
Utility
Compositions and Techniques for Nucleic Acid Primer Extension
5 May 22
A method of characterizing a nucleic acid that includes steps of (a) contacting a primer-template nucleic acid hybrid with a polymerase and a mixture of nucleotides to produce an extended primer hybrid and to form a stabilized ternary complex including the extended primer hybrid, the polymerase and a nucleotide cognate of the next base in the template, wherein the mixture contains nucleotide cognates of four different base types, wherein the nucleotide cognate of the first base type has a reversible terminator, and wherein nucleotide cognates of the second, third and fourth base types are extendable; (b) detecting the stabilized ternary complex to distinguish the next base from other base types in the template; and (c) determining the presence of a base multiplet in the template nucleic acid, the base multiplet including the first base type followed by the next base.
Denis Malyshev, Arnold Oliphant
Filed: 2 Aug 21
Utility
Articles Having Localized Molecules Disposed Thereon and Methods of Producing Same
31 Mar 22
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate.
David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron L. Cicero
Filed: 18 Oct 21
Utility
Producing bragg gratings in optical waveguides
8 Mar 22
We describe methods of producing gratings such as Bragg gratings with optical waveguides.
Mark McDonald, Aaron Rulison, Paul Lundquist, Tsuei-Lian Wang, Deborah Pao-Tung Kwo, Shang Wang
Filed: 11 Apr 19
Utility
Temporal differential active pixel sensor
8 Mar 22
Provided are pixels, devices, systems, and methods relating to active pixel sensor in which each active pixel puts out a signal that represents a temporal differential.
Annette Grot, Stephen Turner, Steven Benjamin Warren
Filed: 5 Jun 20
Utility
Single-molecule Nanofet Sequencing Systems and Methods
3 Mar 22
Real time electronic sequencing devices, chips, and systems are described.
Stephen Turner, Jonas Korlach, Satwik Kamtekar, Jeremiah Hanes
Filed: 10 Sep 21
Utility
Classification of Nucleic Acid Templates
27 Jan 22
Methods, compositions, and systems are provided for characterization of modified nucleic acids.
Benjamin Flusberg, Stephen Turner, Jon Sorenson, Kevin Travers, Cheryl Heiner
Filed: 26 Aug 20
Utility
Intermittent detection during analytical reactions
4 Jan 22
Methods, devices, and systems for performing intermittent detection during analytical reactions are provided.
Stephen Turner, Jon Sorenson, Kenneth Mark Maxham, John Eid
Filed: 21 Oct 19
Utility
Protected dye-labeled reagents
21 Dec 21
Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided.
Lubomir Sebo, Honey Osuna, Stephen Yue, Yuri Lapin
Filed: 31 Jan 20
Utility
Hierarchical silica lamella for magnetic nucleic acid extraction
14 Dec 21
Disclosed herein is a novel method to fabricate magnetic silica nanomembranes using thin polymer cores based on silica deposition and self-wrinkling induced by thermal shrinkage.
Kelvin Jeng-Fang Liu, Jeffrey Michael Burke
Filed: 30 Jun 20
Utility
Recombinant polymerases for incorporation of protein shield nucleotide analogs
14 Dec 21
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification.
Satwik Kamtekar, Erik Miller
Filed: 9 Mar 20
Utility
FRET-labeled compounds and uses therefor
30 Nov 21
FRET-labeled compounds are provided for use in analytical reactions.
Xiangxu Kong, Gene Shen
Filed: 27 Jan 20
Utility
Articles having localized molecules disposed thereon and methods of producing same
30 Nov 21
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate.
David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron L. Cicero
Filed: 14 Apr 20
Utility
Fluorescent Polymerase Enzyme Substrates Having Protein Shields
11 Nov 21
Compositions, methods, and systems are provided for fluorescent polymerase enzyme substrates comprising protein shields for improving enzyme photostability in single molecule real time sequencing.
Keith Bjornson, Jeremiah Hanes, Erik Miller, Satwik Kamtekar, Lubomir Sebo, Louis Brogley
Filed: 14 Apr 21
Utility
Illumination of Integrated Analytical Systems
4 Nov 21
An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device.
Adrian FEHR, Nathaniel Joseph McCAFFREY, Stephen TURNER
Filed: 30 Mar 21
Utility
Multi-amplitude modular labeled compounds
2 Nov 21
Sets of compounds bearing detectably different groups of labels are provided.
Erik Miller, Satwik Kamtekar
Filed: 24 Oct 18
Utility
Arrays of Integrated Analytical Devices
21 Oct 21
Arrays of integrated analytical devices and their methods for production are provided.
Annette GROT, Ravi SAXENA, Paul LUNDQUIST
Filed: 7 Dec 20
Utility
Methods and Compositions for Generating Asymmetrically-tagged Nucleic Acid Fragments
14 Oct 21
The present disclosure provides improved methods for generating asymmetrically-tagged nucleic acid constructs, compositions comprising such constructs, and kits and systems for generating such constructs.
Joan Wilson
Filed: 25 Jun 21
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