15 patents
Utility
ANTI-ERBB3 Antibodies
16 Nov 23
Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/IER3 are disclosed.
Sylvie VINCENT, William M. Winston, JR., Fang Wang, Solly Weiler, Kristan Meetze, Lyne Breault, Steve Bottega, Ting Chen, Michael DePrima, Christina Fleet, Steven Tyler, Jin-Kyeung Woo, Jeno Gyuris
Filed: 26 Apr 23
Utility
Methods of Reversing Cachexia and Prolonging Survival Comprising Administering a GDF15 Modulator and an Anti-cancer Agent
21 Sep 23
Methods are provided for improved treatment of subjects with cancer anorexia-cachexia syndrome, comprising treatment with a combination of at least one anti-cancer agent and at least one GDF15 modulator.
Jeno Gyuris, Lorena Lerner, Jie Lin
Filed: 7 Sep 22
Utility
Anti-GDF-15 antibodies
15 Aug 23
Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed.
Lorena Lerner, Sandra Abbott, Ailin Bai, Ting Chen, Maria Isabel Chiu, Qing Liu, Laura Poling, Nianjun Tao, Solly Weiler, Zhigang Weng, William M. Winston, Jr., Jeno Gyuris
Filed: 19 Mar 20
Utility
Treatment of Congestive Heart Failure and Other Cardiac Dysfunction Using a GDF15 Modulator
22 Dec 22
The invention provides methods and compositions of treating a subject having a cardiac-related disorder such as congestive or chronic heart failure (CHF), cardiac hypertrophy, cardiac hypotrophy, and other cardiac myopathies/dystrophies.
Jeno Gyuris, Lorena Lerner
Filed: 2 Feb 22
Utility
Use of tivozanib to treat subjects with refractory cancer
22 Nov 22
Disclosed is a method of treating cancer, e.g., refractory cancer, with tivozanib.
Michael P. Bailey, Michael N. Needle
Filed: 14 Apr 22
Utility
Use of Tivozanib to Treat Subjects with Refractory Cancer
28 Jul 22
Disclosed is a method of treating cancer, e.g., refractory cancer, with tivozanib.
Michael P. Bailey, Michael N. Needle
Filed: 14 Apr 22
Utility
ANTI-NOTCH3 Antibody
28 Jul 22
Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed.
Heidi Okamura, William M. Winston, JR., Laura Poling, Alisa C. Bell
Filed: 7 Oct 21
Utility
Use of Tivozanib to Treat Subjects with Refractory Cancer
6 Jan 22
Disclosed is a method of treating cancer, e.g., refractory cancer, with tivozanib.
Michael P. Bailey, Michael N. Needle
Filed: 5 Nov 19
Utility
Anti-Notch3 antibody
12 Oct 21
Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed.
Heidi Okamura, William M. Winston, Jr., Laura Poling, Alisa C. Bell
Filed: 28 Apr 17
Utility
ANTI-NOTCH3 Antibodies
10 Jun 21
Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed.
Heidi Okamura, Sandra Abbott, Alisa C. Bell, Kelly Kreuter, Ronan O'Hagan, Samantha Perino, Hamid Tissire, William M. Winston, Jr., Jeno Gyuris
Filed: 13 Aug 20
Utility
ANTI-GDF-15 Antibodies
8 Apr 21
Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed.
Lorena Lerner, Sandra Abbott, Ailin Bai, Ting Chen, Maria Isabel Chiu, Qing Liu, Laura Poling, Nianjun Tao, Solly Weiler, Zhigang Weng, William M. Winston, JR., Jeno Gyuris
Filed: 19 Mar 20
Utility
ANTI-ERBB3 Antibodies
23 Sep 20
Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed.
Sylvie Vincent, William M. Winston, Jr., Fang Wang, Solly Weiler, Kristan Meetze, Lyne Breault, Steve Bottega, Ting Chen, Michael DePrima, Christina Fleet, Steven Tyler, Jin-Kyeung Woo, Jeno Gyuris
Filed: 28 Oct 19
Utility
Anti-NOTCH3 antibodies
17 Aug 20
Monoclonal antibodies that bind and inhibit activation of human Notch3 are disclosed.
Heidi Okamura, Sandra Abbott, Alisa C. Bell, Kelly Kreuter, Ronan O'Hagan, Samantha Perino, Hamid Tissire, William M. Winston, Jr., Jeno Gyuris
Filed: 7 Jan 18
Utility
Anti-GDF15 antibodies
23 Mar 20
Monoclonal antibodies that bind and inhibit the activity of human GDF15 are disclosed.
Lorena Lerner, Sandra Abbott, Ailin Bai, Ting Chen, Maria I. Chiu, Qing Liu, Laura Poling, Nianjun Tao, Solly Weiler, Zhigang Weng, William M. Winston, Jr., Jeno Gyuris
Filed: 19 Jul 17
Utility
Anti-ERBB3 antibodies
2 Dec 19
Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed.
Sylvie Vincent, William M. Winston, Jr., Fang Wang, Solly Weiler, Kristan Meetze, Lyne Breault, Steve Bottega, Ting Chen, Michael DePrima, Christina Fleet, Steven Tyler, Jin-Kyeung Woo, Jeno Gyuris
Filed: 1 Mar 17
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