71 patents
Utility
PD-1 Peptide Inhibitors
28 Dec 23
This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1).
Gabriel M. Gutierrez, Vinayaka Kotraiah, James Pannucci, Ramses Ayala
Filed: 1 Jun 23
Utility
PD-1 peptide inhibitors
24 Oct 23
This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1).
Gabriel M. Gutierrez, Vinayaka Kotraiah, James Pannucci, Ramses Ayala
Filed: 9 Sep 20
Utility
Pocket detection pouch
27 Jun 23
The pocket detection platform (PDP) detects pathogens, toxins and chemicals of interest simultaneously by way of a multi-channeled, soft see-through plastic pouch design that consists of inner and outer compartments that promote compartmentalization and/or unidirectional sample flow.
Kelley D. Betts, Jennifer W. Sekowski
Filed: 7 Aug 20
Utility
Portable fluidic platform for rapid cell-free production of protein biologics
2 May 23
A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation.
John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
Filed: 10 Apr 20
Utility
Systems and methods for image processing
2 May 23
A computing-device implemented system and method for identifying an item in an x-ray image is described.
David Perticone, Andrew D. Foland
Filed: 9 Nov 20
Utility
Acoustic Vector Sensor
27 Apr 23
A horizontal acoustic vector sensor system described herein includes a housing which has a gimbal assembly therein which is attached to a sensor assembly which has multiple pairs of seismometers that arranged orthogonally to one or more neighboring pairs of seismometers, along an approximately horizontal axis.
Norman Gholson, David C. Blain
Filed: 2 Dec 22
Utility
System and Method for Hyperdimensional Computing (HDC) For Activation Map Analysis (AMA)
13 Apr 23
An Activation Map Analysis (AMA) system attaches to an existing deep neural network (host network) as an observer that analyzes the internal activities of the host network to provide additional information, e.g., metrics for resilience, interpretability, and adversarial defense, to the end-user.
Weicheng Shen, Roopa M. Vasan, Victor M. Miranda
Filed: 26 May 22
Utility
Materials and methods for cell-free expression of vaccine epitope concatemers
21 Mar 23
The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications.
Stephen A. Chappell, Vincent P. Mauro, John Dresios
Filed: 1 Jul 19
Utility
Air Treatment System Using Photocatalytic Oxidation (Pco)
9 Mar 23
Aspects of the present disclosure provide a system for abating a hydrocarbon compound (HCC) in air using photocatalytic oxidation (PCO).
William Ronald STEEN, Paul Edward FLOYD, Jason Edward JARRELL
Filed: 3 Dec 21
Utility
Acoustic vector sensor
21 Feb 23
An acoustic vector sensor (“AVS”) includes one or more sensitive elements arranged in an orthogonal configuration to provide high-sensitivity directional performance.
Brian Hamburg, Norman Gholson
Filed: 13 Apr 20
Utility
LAG3 binding peptides
14 Feb 23
This disclosure provides peptides that bind to LAG3 and can be used to block its interaction with other molecules such as MHC-II, FGL1, and α-synuclein.
Gabriel M. Gutierrez, James Pannucci, Vinayaka Kotraiah, Timothy W. Phares, Cecilie D. Browne
Filed: 28 Jul 21
Utility
Method and System For Accelerating Rapid Class Augmentation for Object Detection in Deep Neural Networks
12 Jan 23
Object detection architectures for detecting and classifying objects in an image are modified to incorporate an extending Rapid Class Augmentation (XRCA) progressive learning algorithm with its defining aspect of memory built into its optimizer which allows joint optimization over both the old and the classes using just the new class data and eliminates the issues associated with catastrophic forgetting.
Hanna Witzgall
Filed: 14 Jun 22
Utility
K-Ras modulators
3 Jan 23
Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.
Frank McCormick, Adam R. Renslo, David Turner, Stephan Gysin, Anna E. Maciag, Oleg Chertov
Filed: 28 Oct 20
Utility
LAG3 Binding Peptides
15 Dec 22
This disclosure provides peptides which bind to LAG3, such as SAPWEPLHWPEDWWQGTGEW (SEQ ID NO:1), and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein.
Gabriel M. Gutierrez, Vinayaka Kotraiah, Timothy W. Phares, James Pannucci, Marc Mansour
Filed: 30 Jun 22
Utility
Motion Extended Array Synthesis For Use in High Resolution Imaging Applications
29 Sep 22
A process and systems for constructing arbitrarily large virtual arrays using two or more collection platforms (e.g.
John R. Kendra
Filed: 11 Jan 22
Utility
Chemical trace detection system
27 Sep 22
A chemical trace detection system includes: a drift tube; a detector disposed within the drift tube; a voltage source to produce an electrical field in the drift tube; an ionizer to establish an ionization region adjacent to the electrical field; and a desorber including a sample holder to hold a sample in or adjacent to the ionization region and a sample heater to desorb particles of the sample held in the sample holder such that the desorbed particles are introduced directly into the ionization region from the sample holder to form ionized particles that are forced toward the detector by the electrical field.
Hacene Boudries, Troy Velazquez, Anatoly Lazarevich, Dmitriy Ivashin, Andrew Anderson
Filed: 21 May 20
Utility
Chemical Trace Detection System
1 Sep 22
A chemical trace detection system includes: a drift tube; a detector disposed within the drift tube; a voltage source to produce an electrical field in the drift tube; an ionizer to establish an ionization region adjacent to the electrical field; and a desorber including a sample holder to hold a sample in or adjacent to the ionization region and a sample heater to desorb particles of the sample held in the sample holder such that the desorbed particles are introduced directly into the ionization region from the sample holder to form ionized particles that are forced toward the detector by the electrical field.
Hacene Boudries, Troy Velazquez, Anatoly Lazarevich, Dmitriy Ivashin, Andrew Anderson
Filed: 25 Apr 22
Utility
LAG3 binding peptides
9 Aug 22
This disclosure provides peptides which bind to LAG3, such as SAPWEPLHWPEDWWQGTGEW (SEQ ID NO:1), and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein.
Gabriel M. Gutierrez, Vinayaka Kotraiah, Timothy W. Phares, James Pannucci, Marc Mansour
Filed: 21 May 20
Utility
K-Ras modulators
14 Jun 22
Frank McCormick, Adam Renslo, David Turner, Anna E. Maciag, Marcin Dyba, Elizabeth D. Vo, Joseph Saavedra, Vandana Kumari
Filed: 20 Apr 18
Utility
Immunomodulatory compounds
24 May 22
This disclosure provides peptide conjugates that are useful for inhibiting the progression of a hyperproliferative disorder, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, enhancing a response to a vaccine, or inhibiting the progression of a synucleinopathy.
Gabriel M. Gutierrez, James Pannucci, Vinayaka Kotraiah, Timothy W. Phares, Cecille D. Browne
Filed: 3 Jun 21