38 patents
Utility
PD-1 peptide inhibitors
24 Oct 23
This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1).
Gabriel M. Gutierrez, Vinayaka Kotraiah, James Pannucci, Ramses Ayala
Filed: 9 Sep 20
Utility
Pocket detection pouch
27 Jun 23
The pocket detection platform (PDP) detects pathogens, toxins and chemicals of interest simultaneously by way of a multi-channeled, soft see-through plastic pouch design that consists of inner and outer compartments that promote compartmentalization and/or unidirectional sample flow.
Kelley D. Betts, Jennifer W. Sekowski
Filed: 7 Aug 20
Utility
Portable fluidic platform for rapid cell-free production of protein biologics
2 May 23
A portable fluidic platform for rapid and flexible end-to-end production of recombinant protein biologics includes a bioreactor system hosting stable and robust cell-free translation systems that is fluidically integrated with modular protein separation functionalities (e.g., size exclusion, ion exchange or affinity chromatography systems) for purification of the cell-free expressed product and which are configurable for process-specific isolation of different proteins, as well as for formulation.
John Dresios, Richard Holmes Griffey, Challise J. Sullivan, Erik D. Pendleton, Henri M. Sasmor, William L. Hicks, Eric M. Amendt
Filed: 10 Apr 20
Utility
Systems and methods for image processing
2 May 23
A computing-device implemented system and method for identifying an item in an x-ray image is described.
David Perticone, Andrew D. Foland
Filed: 9 Nov 20
Utility
Materials and methods for cell-free expression of vaccine epitope concatemers
21 Mar 23
The present disclosure provides materials and methods for cell-free expression of epitopes for immunotherapy applications.
Stephen A. Chappell, Vincent P. Mauro, John Dresios
Filed: 1 Jul 19
Utility
Acoustic vector sensor
21 Feb 23
An acoustic vector sensor (“AVS”) includes one or more sensitive elements arranged in an orthogonal configuration to provide high-sensitivity directional performance.
Brian Hamburg, Norman Gholson
Filed: 13 Apr 20
Utility
LAG3 binding peptides
14 Feb 23
This disclosure provides peptides that bind to LAG3 and can be used to block its interaction with other molecules such as MHC-II, FGL1, and α-synuclein.
Gabriel M. Gutierrez, James Pannucci, Vinayaka Kotraiah, Timothy W. Phares, Cecilie D. Browne
Filed: 28 Jul 21
Utility
K-Ras modulators
3 Jan 23
Provided herein, inter alia, are methods and compounds for inhibiting K-Ras and for treating cancer.
Frank McCormick, Adam R. Renslo, David Turner, Stephan Gysin, Anna E. Maciag, Oleg Chertov
Filed: 28 Oct 20
Utility
Chemical trace detection system
27 Sep 22
A chemical trace detection system includes: a drift tube; a detector disposed within the drift tube; a voltage source to produce an electrical field in the drift tube; an ionizer to establish an ionization region adjacent to the electrical field; and a desorber including a sample holder to hold a sample in or adjacent to the ionization region and a sample heater to desorb particles of the sample held in the sample holder such that the desorbed particles are introduced directly into the ionization region from the sample holder to form ionized particles that are forced toward the detector by the electrical field.
Hacene Boudries, Troy Velazquez, Anatoly Lazarevich, Dmitriy Ivashin, Andrew Anderson
Filed: 21 May 20
Utility
LAG3 binding peptides
9 Aug 22
This disclosure provides peptides which bind to LAG3, such as SAPWEPLHWPEDWWQGTGEW (SEQ ID NO:1), and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein.
Gabriel M. Gutierrez, Vinayaka Kotraiah, Timothy W. Phares, James Pannucci, Marc Mansour
Filed: 21 May 20
Utility
K-Ras modulators
14 Jun 22
Frank McCormick, Adam Renslo, David Turner, Anna E. Maciag, Marcin Dyba, Elizabeth D. Vo, Joseph Saavedra, Vandana Kumari
Filed: 20 Apr 18
Utility
Immunomodulatory compounds
24 May 22
This disclosure provides peptide conjugates that are useful for inhibiting the progression of a hyperproliferative disorder, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, enhancing a response to a vaccine, or inhibiting the progression of a synucleinopathy.
Gabriel M. Gutierrez, James Pannucci, Vinayaka Kotraiah, Timothy W. Phares, Cecille D. Browne
Filed: 3 Jun 21
Utility
Chemical trace detection system
26 Apr 22
A chemical trace detection system includes: a drift tube; a detector disposed within the drift tube; a voltage source to produce an electrical field in the drift tube; an ionizer to establish an ionization region adjacent to the electrical field; and a desorber including a sample holder to hold a sample in or adjacent to the ionization region and a sample heater to desorb particles of the sample held in the sample holder such that the desorbed particles are introduced directly into the ionization region from the sample holder to form ionized particles that are forced toward the detector by the electrical field.
Hacene Boudries, Troy Velazquez, Anatoly Lazarevich, Dmitriy Ivashin, Andrew Anderson
Filed: 31 Aug 18
Utility
Motion extended array synthesis for use in high resolution imaging applications
15 Feb 22
A process and systems for constructing arbitrarily large virtual arrays using two or more collection platforms (e.g.
John R. Kendra
Filed: 30 Sep 20
Utility
Quantum detection and tracking of pulsed optical signals
25 Jan 22
Apparatus for detecting pulse optical position modulated signals with high background noise by detection of quantum arrival rate at the detector are described.
James Charles Lundberg, Christopher Hochuli Fisher, Mark Edwin Krepel
Filed: 6 Oct 20
Utility
Low-power mass interrogation system and assay for determining vitamin D levels
18 Jan 22
A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.
Noah Peter Christian
Filed: 30 Apr 19
Utility
Sensor array multiplexer
30 Nov 21
A system for collecting data from multiple sensors at a central node is described.
Mitchell Eric Boler, Steven Michael Johnson
Filed: 17 Sep 19
Utility
Standoff trace chemical detection with active infrared spectroscopy
22 Jun 21
A system and process scans a target area at a distance of 3-30 m for one or more materials.
Augie Ifarraguerri, Brian Gorin, J. Frank Camacho, Noah Christian, Robert Rice
Filed: 15 Apr 20
Utility
PD-1 and CTLA-4 dual inhibitor peptides
15 Jun 21
This disclosure provides peptides which have a strong affinity for the checkpoint receptor “programmed death 1” (PD-1).
Gabriel M. Gutierrez, Vinayaka Kotraiah, Timothy W. Phares, James Pannucci
Filed: 25 May 18
Utility
Low power mass analyzer and system integrating same for chemical analysis
4 May 21
A low power mass spectrometer (LPMS) includes an ionization source for generating an ionized sample beam; ion focusing optics for focusing the sample beam; and a static magnetic field region contained within an electric field-free drift region created between magnets acting as equipotential electrodes combined with a third equipotential surrounding electrode for receiving the focused sample beam and deflecting ions therein to different points on a detector array in accordance with an individual mass thereof.
Noah Christian
Filed: 25 Sep 20