30 patents
Utility
Therapeutic compositions comprising anti-NRP2 antibodies
7 Nov 23
Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
Luke Burman, Yeeting Chong, Leslie Ann Greene, David King, Zhiwen Xu, Ryan Andrew Adams
Filed: 2 Oct 20
Utility
Compositions and Methods Comprising ANTI-NRP2 Antibodies
5 Oct 23
Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
Luke G. BURMAN, Yee Ting (Esther) CHONG, Yanyan GENG, Leslie Nangle GREENE, Kristina HAMEL, David KING, Ann MENEFEE, Kaitlyn RAUCH, Zhiwen XU, Liting ZHAI
Filed: 20 Oct 22
Utility
Compositions and methods for treating lung inflammation
26 Sep 23
Provided are therapies, including combination therapies, for the treatment of lung inflammation, including interstitial lung diseases (ILDs), which include the use of at least one histidyl-tRNA synthetase (HRS) polypeptide or an expressible polynucleotide that encodes the HRS polypeptide, alone or in combination with at least one immunomodulatory agent.
John D. Mendlein, Kathleen Ogilvie
Filed: 19 Apr 18
Utility
Compositions and Methods for Treating NRP2-ASSOCIATED Diseases
9 Feb 23
Provided are therapies, including standalone and combination therapies, for treating neuropilin-2 (NRP2)-associated diseases and conditions, which include the use of at least one histidyl-tRNA synthetase (HRS) polypeptide.
Christoph BURKART, Kathleen M. OGILVIE, Suzanne PAZ, Sanna ROSENGREN, Kaustubh DATTA, Samikshan DUTTA
Filed: 15 Jun 22
Utility
Compositions and methods comprising anti-NRP2 antibodies
22 Nov 22
Provided are antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, for example, human histidyl-tRNA synthetase (HRS), and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
Luke Burman, Yee Ting (Esther) Chong, Yanyan Geng, Leslie Nangle Greene, Kristina Hamel, David King, Ann Menefee, Kaitlyn Rauch, Zhiwen Xu, Liting Zhai
Filed: 5 Apr 19
Utility
Compositions and Methods Comprising Histidyl-trna Synthetase Splice Variants Having Non-canonical Biological Activities
31 Mar 22
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
Filed: 23 Jun 21
Utility
Histidyl-trna Synthetase-fc Conjugates
31 Mar 22
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions.
Chi-Fang WU, Darin LEE, Jeffry D. WATKINS, Kristi PIEHL, Kyle CHIANG, Marc THOMAS, Minh-Ha DO, Ying BUECHLER, John D. MENDLEIN
Filed: 10 Jun 21
Utility
Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
3 Aug 21
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
Filed: 7 Apr 20
Utility
Histidyl-tRNA synthetase-Fc conjugates
27 Jul 21
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions.
Chi-Fang Wu, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
Filed: 7 Apr 20
Utility
Compositions and Methods Comprising ANTI-NRP2 Antibodies
3 Jun 21
Provided are affinity matured and humanized antibodies and antigen-binding fragments thereof that specifically bind to human neuropilin-2 (NRP2) polypeptides, including those that modulate binding interactions between human NRP2 and at least one NRP2 ligand, and which thereby modulate subsequent NRP2-mediated downstream signaling events, including related therapeutic compositions and methods for modulating NRP2 activity and treating diseases such as NRP2-associated diseases.
Luke BURMAN, Yeeting CHONG, Leslie Ann GREENE, David KING, Zhiwen XU, Ryan Andrew ADAMS
Filed: 2 Oct 20
Utility
Compositions and methods comprising histidyl-tRNA synthetase splice variants having non-canonical biological activities
9 Mar 21
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Jie Zhou, Ching-Fun Lau, Zhiwen Xu, Wing-Sze Lo, Kristi Helen Piehl, Leslie Ann Greene
Filed: 19 Nov 19
Utility
Compositions and Methods for Treating Lung Inflammation
2 Dec 20
Provided are therapies, including combination therapies, for the treatment of lung inflammation, including interstitial lung diseases (ILDs), which include the use of at least one histidyl-tRNA synthetase (HRS) polypeptide or an expressible polynucleotide that encodes the HRS polypeptide, alone or in combination with at least one immunomodulatory agent.
John D. MENDLEIN, Kathleen OGILVIE
Filed: 18 Apr 18
Utility
Histidyl-trna Synthetase-fc Conjugates
9 Sep 20
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions.
Chi-Fang WU, Darin LEE, Jeffry D. WATKINS, Kristi PIEHL, Kyle P. CHIANG, Marc THOMAS, Minh-Ha DO, Ying BUECHLER, John D. MENDLEIN
Filed: 6 Apr 20
Utility
Innovative Discovery of Therapeutic, Diagnostic, and Antibody Compositions Related to Protein Fragments of Seryl-trna Synthetases
22 Jul 20
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Leslie Ann GREENE, Kyle P. CHIANG, Fei HONG, Alain P. VASSEROT, Wing-Sze LO, Jeffry D. Watkins, Cheryl L. QUINN, John D. Mendlein
Filed: 20 Nov 19
Utility
Compositions and Methods Comprising Histidyl-trna Synthetase Splice Variants Having Non-canonical Biological Activities
22 Jul 20
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
Filed: 6 Apr 20
Utility
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Cysteinyl-tRNA synthetase
20 Jul 20
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain P. Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
Filed: 18 Jun 18
Utility
Innovative Discovery of Therapeutic, Diagnostic, and Antibody Compositions Related to Protein Fragments of Alanyl Trna Synthetases
15 Jul 20
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Leslie Ann GREENE, Kyle P. CHIANG, Fei HONG, Alain P. VASSEROT, Wing-Sze LO, Jeffry D. Watkins, Cheryl L. QUINN, John D. Mendlein
Filed: 20 Nov 19
Utility
Histidyl-tRNA synthetase-Fc conjugates
13 Jul 20
The present invention provides histidyl-tRNA synthetase and Fc region conjugate polypeptides (HRS-Fc conjugates), such as HRS-Fc fusion polypeptides, compositions comprising the same, and methods of using such conjugates and compositions for treating or diagnosing a variety of conditions.
Chi-Fang Wu, Darin Lee, Jeffry D. Watkins, Kristi Piehl, Kyle P. Chiang, Marc Thomas, Minh-Ha Do, Ying Buechler, John D. Mendlein
Filed: 19 Sep 19
Utility
Compositions and Methods Comprising Histidyl-trna Synthetase Splice Variants Having Non-canonical Biological Activities
8 Jul 20
Isolated histidyl-tRNA synthetase splice variant polynucleotides and polypeptides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
Jie ZHOU, Ching-Fun LAU, Zhiwen XU, Wing-Sze LO, Kristi Helen PIEHL, Leslie Ann GREENE
Filed: 18 Nov 19
Utility
Innovative Discovery of Therapeutic, Diagnostic, and Antibody Compositions Related to Protein Fragments of Glutaminyl-trna Synthetases
3 Jun 20
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Leslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain P. Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
Filed: 26 Sep 19